SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 6 VAL A 305
VAL A 123
ILE A 272
ARG A  37
 None
 1.05A 1iepA-4m0xA:
undetectable		 1iepA-4m0xA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 7 LEU A 278
ILE A   5
MET A   8
MET A  93
 None
 1.18A 1kglA-4m0xA:
undetectable		 1kglA-4m0xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 4 ILE A 187
LEU A 184
VAL A 180
ALA A 173
 None
 0.91A 1mz9A-4m0xA:
undetectable		 1mz9A-4m0xA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 5 ILE A 187
LEU A 184
VAL A 180
ALA A 173
 None
 0.92A 1mz9C-4m0xA:
undetectable		 1mz9C-4m0xA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 THR A  52
GLU A  64
HIS A  30
 None
 0.85A 1xwfA-4m0xA:
undetectable		 1xwfA-4m0xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 THR A  52
GLU A  64
HIS A  30
 None
 0.85A 1xwfB-4m0xA:
undetectable		 1xwfB-4m0xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 THR A  52
GLU A  64
HIS A  30
 None
 0.85A 1xwfC-4m0xA:
undetectable		 1xwfC-4m0xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 THR A  52
GLU A  64
HIS A  30
 None
 0.87A 1xwfD-4m0xA:
undetectable		 1xwfD-4m0xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 8 LEU A 240
LEU A 210
ALA A 214
MET A 168
 None
 1.08A 2wekA-4m0xA:
undetectable		 2wekA-4m0xA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 7 ASP A 113
SER A 356
SER A 304
GLU A 335
 None
 1.16A 3bc9A-4m0xA:
7.5		 3bc9A-4m0xA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 ASP A  82
SER A  84
ARG A 118
 None
 0.95A 3loqA-4m0xA:
2.7		 3loqA-4m0xA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 ARG A 118
THR A 109
TRP A 112
 None
 1.23A 4d7hA-4m0xA:
undetectable		 4d7hA-4m0xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 8 VAL A  97
ILE A  69
SER A 101
ALA A  50
 None
 1.00A 4eyzB-4m0xA:
undetectable		 4eyzB-4m0xA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		5 / 12 PHE A 296
ALA A 294
ALA A 246
ALA A 256
LEU A 259
 None
 1.02A 4oaeA-4m0xA:
1.4		 4oaeA-4m0xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		5 / 12 GLY A 297
ALA A 298
PHE A 268
ALA A 246
VAL A 265
 None
 1.26A 4ryaA-4m0xA:
undetectable		 4ryaA-4m0xA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		6 / 12 ALA A 106
ILE A 309
THR A 109
SER A   9
GLY A  46
GLY A 355
 None
 1.31A 4rzvA-4m0xA:
undetectable		 4rzvA-4m0xA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 ARG A 118
THR A 109
TRP A 112
 None
 1.20A 4ug5A-4m0xA:
undetectable		 4ug5A-4m0xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 ARG A 118
THR A 109
TRP A 112
 None
 1.23A 4uglA-4m0xA:
undetectable		 4uglA-4m0xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		5 / 12 LEU A  74
THR A  52
ALA A  50
VAL A  36
ALA A  10
 None
 1.01A 4x1kD-4m0xA:
3.7		 4x1kD-4m0xA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		5 / 12 LEU A  74
THR A  52
ALA A  50
VAL A  36
ALA A  10
 None
 0.94A 4x1yD-4m0xA:
3.1		 4x1yD-4m0xA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		5 / 9 GLY A 276
SER A 101
GLU A  61
ILE A 272
ALA A 281
 None
 1.39A 5entC-4m0xA:
undetectable		 5entC-4m0xA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		3 / 3 ARG A 118
THR A 109
TRP A 112
 None
 1.22A 5g6cA-4m0xA:
undetectable		 5g6cA-4m0xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		5 / 12 ASP A 334
GLU A 335
SER A 303
ARG A 366
LEU A 360
 None
 1.34A 5nd2B-4m0xA:
undetectable		 5nd2B-4m0xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		4 / 4 VAL A 123
GLY A 355
ASP A 113
ASP A 114
 None
 1.32A 6cjkC-4m0xA:
undetectable		 6cjkC-4m0xA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4m0x CHLOROMUCONATE
CYCLOISOMERASE
(Rhodococcus
opacus) 		5 / 11 GLY A 263
LEU A 293
ALA A 288
ALA A 256
PHE A 268
 None
 1.41A 6qgbE-4m0xA:
undetectable		 6qgbE-4m0xA:
20.13