SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 ILE A 273
LEU A 176
LEU A 262
ALA A 263
ILE A 269
 None
 1.25A 1g5yB-4m1eA:
undetectable		 1g5yB-4m1eA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 11 TYR A 161
PRO A 141
LEU A 142
HIS A 133
ALA A 221
 None
 1.45A 1hk3A-4m1eA:
undetectable		 1hk3A-4m1eA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		4 / 7 TYR A 161
ILE A  28
HIS A 133
LEU A 219
 None
 1.09A 1j96B-4m1eA:
undetectable		 1j96B-4m1eA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 GLY A 116
GLU A 194
VAL A 210
MET A 212
ASP A 236
 ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-4.2A)
ADE  A 401 (-3.0A)
 0.55A 1jdvE-4m1eA:
12.8
1jdvF-4m1eA:
21.0		 1jdvE-4m1eA:
21.29
1jdvF-4m1eA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		6 / 10 GLY A 116
GLU A 194
VAL A 210
GLY A 211
MET A 212
THR A 235
 ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
ADE  A 401 (-4.3A)
 0.33A 1pwyE-4m1eA:
39.2		 1pwyE-4m1eA:
45.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		6 / 10 GLY A 116
GLU A 194
VAL A 210
GLY A 211
MET A 212
THR A 235
 ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
ADE  A 401 (-4.3A)
 0.23A 1v3qE-4m1eA:
39.8		 1v3qE-4m1eA:
45.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 ILE A  74
LEU A  71
ALA A  24
GLY A  26
LEU A  29
 None
 1.30A 2a58A-4m1eA:
4.3
2a58B-4m1eA:
4.2		 2a58A-4m1eA:
20.00
2a58B-4m1eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 ILE A  74
LEU A  71
ALA A  24
GLY A  26
LEU A  29
 None
 1.29A 2a58B-4m1eA:
4.3
2a58C-4m1eA:
4.5		 2a58B-4m1eA:
20.00
2a58C-4m1eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 ILE A  74
LEU A  71
ALA A  24
GLY A  26
LEU A  29
 None
 1.30A 2a58D-4m1eA:
4.4
2a58E-4m1eA:
4.4		 2a58D-4m1eA:
20.00
2a58E-4m1eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		3 / 3 MET A 212
VAL A 220
GLU A 139
 ADE  A 401 (-4.2A)
None
None
 0.91A 2x9gA-4m1eA:
undetectable		 2x9gA-4m1eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		4 / 8 GLY A  26
VAL A 106
PRO A  23
TRP A  19
 None
 1.01A 3bgdB-4m1eA:
undetectable		 3bgdB-4m1eA:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		4 / 6 GLY A 116
GLU A 194
GLY A 211
MET A 212
 ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
 0.48A 3e9rA-4m1eA:
38.4		 3e9rA-4m1eA:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		4 / 6 GLY A 116
GLU A 194
GLY A 211
MET A 212
 ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
 0.48A 3e9rC-4m1eA:
38.3		 3e9rC-4m1eA:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		7 / 12 TYR A  86
ALA A 114
GLY A 116
GLU A 194
VAL A 210
GLY A 211
MET A 212
 None
SO4  A 400 ( 3.9A)
ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
 0.34A 3f8wA-4m1eA:
39.8		 3f8wA-4m1eA:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		7 / 12 HIS A  84
TYR A  86
GLY A 116
GLU A 194
VAL A 210
GLY A 211
MET A 212
 SO4  A 400 (-3.9A)
None
ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
 0.36A 3f8wB-4m1eA:
41.5		 3f8wB-4m1eA:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		8 / 12 HIS A  84
TYR A  86
ALA A 114
GLY A 116
GLU A 194
VAL A 210
GLY A 211
MET A 212
 SO4  A 400 (-3.9A)
None
SO4  A 400 ( 3.9A)
ADE  A 401 (-3.7A)
ADE  A 401 (-2.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-3.4A)
ADE  A 401 (-4.2A)
 0.35A 3f8wC-4m1eA:
39.5		 3f8wC-4m1eA:
43.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 GLY A 259
GLY A 258
VAL A 233
LEU A  29
MET A  27
 None
 1.10A 3h52B-4m1eA:
undetectable		 3h52B-4m1eA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_A_AG2A1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 9 SER A 213
HIS A  62
GLY A  30
ASP A 236
LEU A 193
 SO4  A 400 (-2.5A)
SO4  A 400 (-4.5A)
SO4  A 400 (-3.3A)
ADE  A 401 (-3.0A)
ADE  A 401 (-4.5A)
 1.05A 3n2oA-4m1eA:
0.3
3n2oB-4m1eA:
0.2		 3n2oA-4m1eA:
18.04
3n2oB-4m1eA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 10 SER A 213
HIS A  62
GLY A  30
ASP A 236
LEU A 193
 SO4  A 400 (-2.5A)
SO4  A 400 (-4.5A)
SO4  A 400 (-3.3A)
ADE  A 401 (-3.0A)
ADE  A 401 (-4.5A)
 1.15A 3n2oC-4m1eA:
undetectable
3n2oD-4m1eA:
undetectable		 3n2oC-4m1eA:
18.04
3n2oD-4m1eA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 GLY A 116
VAL A 210
MET A 212
ASP A 236
CYH A 238
 ADE  A 401 (-3.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-4.2A)
ADE  A 401 (-3.0A)
ADE  A 401 (-3.4A)
 0.51A 3u40B-4m1eA:
20.2
3u40C-4m1eA:
19.9		 3u40B-4m1eA:
22.46
3u40C-4m1eA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 GLY A 116
VAL A 210
MET A 212
ASP A 236
CYH A 238
 ADE  A 401 (-3.7A)
ADE  A 401 (-4.4A)
ADE  A 401 (-4.2A)
ADE  A 401 (-3.0A)
ADE  A 401 (-3.4A)
 0.42A 3u40D-4m1eA:
20.2
3u40E-4m1eA:
19.8		 3u40D-4m1eA:
22.46
3u40E-4m1eA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		4 / 5 ARG A 170
MET A 166
HIS A 165
LEU A 229
 6PC  A 402 (-2.8A)
None
None
None
 1.44A 4g5jA-4m1eA:
undetectable		 4g5jA-4m1eA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		4 / 4 ASN A 135
SER A 189
ALA A 187
VAL A 186
 None
 1.21A 4x1kC-4m1eA:
3.3		 4x1kC-4m1eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		4 / 4 ASN A 135
SER A 189
ALA A 187
VAL A 186
 None
 1.29A 5nm5A-4m1eA:
3.0		 5nm5A-4m1eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 12 GLU A  87
PRO A 191
GLU A 194
THR A 235
GLY A 116
 None
None
ADE  A 401 (-2.7A)
ADE  A 401 (-4.3A)
ADE  A 401 (-3.7A)
 1.14A 5xioA-4m1eA:
2.8		 5xioA-4m1eA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 10 PHE A 231
LEU A 110
ILE A 129
ILE A 269
ILE A 273
 None
 1.06A 6ebpD-4m1eA:
undetectable		 6ebpD-4m1eA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 11 PHE A 231
LEU A 110
ILE A 129
ILE A 269
ILE A 273
 None
 1.06A 6ebzA-4m1eA:
undetectable		 6ebzA-4m1eA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 11 PHE A 231
LEU A 110
ILE A 129
ILE A 269
ILE A 273
 None
 1.07A 6ebzB-4m1eA:
undetectable		 6ebzB-4m1eA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE
(Planctopirus
limnophila) 		5 / 11 PHE A 231
LEU A 110
ILE A 129
ILE A 269
ILE A 273
 None
 1.05A 6ebzC-4m1eA:
undetectable		 6ebzC-4m1eA:
14.72