SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		4 / 4 ILE A 247
LEU A 248
VAL A  29
ALA A  58
 None
 1.01A 1mz9A-4m1qA:
undetectable		 1mz9A-4m1qA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		3 / 3 TRP A 185
LEU A 182
LYS A 298
 None
 1.13A 1yajK-4m1qA:
undetectable		 1yajK-4m1qA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 LEU A 240
ILE A 118
GLY A 144
HIS A 177
ASP A 150
 None
 0.84A 1zz1C-4m1qA:
undetectable		 1zz1C-4m1qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 ILE A  11
GLY A  12
GLY A  14
LEU A  38
ALA A  80
 None
None
None
None
MPD  A 404 ( 4.2A)
 0.94A 2fk8A-4m1qA:
5.6		 2fk8A-4m1qA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 TYR A 265
ILE A 254
TYR A 172
THR A 147
LEU A 182
 None
PO4  A 401 ( 4.1A)
PO4  A 401 (-4.3A)
None
None
 1.42A 2mjiA-4m1qA:
undetectable		 2mjiA-4m1qA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 9 LEU A 243
ILE A 173
GLY A 175
ILE A 272
ILE A 148
 None
 1.18A 2r5qA-4m1qA:
undetectable		 2r5qA-4m1qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 9 LEU A 243
ILE A 173
GLY A 175
ILE A 272
ILE A 148
 None
 1.18A 2r5qC-4m1qA:
undetectable		 2r5qC-4m1qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 ILE A 148
GLY A 144
ILE A 119
VAL A  16
ILE A 236
 None
 1.01A 3d1zA-4m1qA:
undetectable		 3d1zA-4m1qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 GLY A 171
THR A 151
SER A 186
ILE A 190
LEU A 158
 None
 1.30A 3iv6A-4m1qA:
4.1		 3iv6A-4m1qA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 GLY A 171
THR A 151
SER A 186
ILE A 190
LEU A 158
 None
 1.26A 3iv6C-4m1qA:
4.3		 3iv6C-4m1qA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 9 ILE A 148
GLY A 144
ILE A 119
VAL A  16
ILE A 236
 None
 1.11A 3nuoA-4m1qA:
undetectable		 3nuoA-4m1qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 10 ILE A 173
PHE A 154
SER A 186
ILE A 195
THR A 256
 None
 1.12A 3qgtA-4m1qA:
undetectable		 3qgtA-4m1qA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		4 / 7 PRO A 123
VAL A 126
ALA A 130
PHE A 101
 None
 1.07A 4lb2A-4m1qA:
undetectable		 4lb2A-4m1qA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 9 ASP A  37
TYR A  67
ALA A  80
ILE A 100
ILE A 104
 None
None
MPD  A 404 ( 4.2A)
MPD  A 404 (-3.4A)
None
 0.52A 4oknB-4m1qA:
42.5		 4oknB-4m1qA:
37.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 9 ILE A 148
GLY A 144
ILE A 119
VAL A  16
ILE A 236
 None
 1.17A 5kr0A-4m1qA:
undetectable		 5kr0A-4m1qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 PHE A 113
ALA A 120
SER A 145
VAL A  77
ILE A  78
 None
 1.38A 5mlmA-4m1qA:
8.8		 5mlmA-4m1qA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		4 / 8 VAL A   8
ILE A 118
ALA A 246
LEU A 248
 None
 0.73A 5og9A-4m1qA:
undetectable		 5og9A-4m1qA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4m1q L-LACTATE
DEHYDROGENASE
([Bacillus]
selenitireducens) 		5 / 12 LEU A 291
ILE A 272
LEU A 182
ALA A 286
MET A 261
 None
 1.15A 5og9B-4m1qA:
undetectable		 5og9B-4m1qA:
19.62