SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  46
TRP A 276
 None
 1.23A 1c4dA-4m1rA:
undetectable
1c4dB-4m1rA:
undetectable		 1c4dA-4m1rA:
4.56
1c4dB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 TRP A  51
VAL A  44
TRP A  46
 None
 1.18A 1c4dC-4m1rA:
undetectable
1c4dD-4m1rA:
undetectable		 1c4dC-4m1rA:
4.56
1c4dD-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 PHE A 243
TRP A 240
GLU A 236
 None
 1.08A 1mogA-4m1rA:
undetectable		 1mogA-4m1rA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 ASN A 257
ALA A 265
ASN A 253
 None
 0.80A 1n4fA-4m1rA:
undetectable		 1n4fA-4m1rA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 GLU A 132
ASN A 131
TRP A  28
 TRS  A 301 (-2.7A)
TRS  A 301 (-3.3A)
TRS  A 301 ( 4.8A)
 1.11A 1r15C-4m1rA:
undetectable		 1r15C-4m1rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 GLU A 132
ASN A 131
TRP A  28
 TRS  A 301 (-2.7A)
TRS  A 301 (-3.3A)
TRS  A 301 ( 4.8A)
 1.17A 1r15D-4m1rA:
undetectable		 1r15D-4m1rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 GLU A 132
ASN A 131
TRP A  28
 TRS  A 301 (-2.7A)
TRS  A 301 (-3.3A)
TRS  A 301 ( 4.8A)
 1.14A 1r15E-4m1rA:
undetectable		 1r15E-4m1rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 GLU A 132
ASN A 131
TRP A  28
 TRS  A 301 (-2.7A)
TRS  A 301 (-3.3A)
TRS  A 301 ( 4.8A)
 1.11A 1r15F-4m1rA:
undetectable		 1r15F-4m1rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 ASN A 131
GLU A 132
HIS A 192
GLU A 220
TRP A 254
 TRS  A 301 (-3.3A)
TRS  A 301 (-2.7A)
None
TRS  A 301 (-2.7A)
TRS  A 301 (-4.1A)
 0.53A 2v3dA-4m1rA:
16.7		 2v3dA-4m1rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  46
TRP A  51
 None
 1.10A 2xdcA-4m1rA:
undetectable
2xdcB-4m1rA:
undetectable		 2xdcA-4m1rA:
4.56
2xdcB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  51
TRP A  46
 None
 0.97A 2xdcA-4m1rA:
undetectable
2xdcB-4m1rA:
undetectable		 2xdcA-4m1rA:
4.56
2xdcB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 TRP A  46
VAL A  44
TRP A  51
 None
 0.96A 2xdcA-4m1rA:
undetectable
2xdcB-4m1rA:
undetectable		 2xdcA-4m1rA:
4.56
2xdcB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 TRP A  51
VAL A  44
TRP A  46
 None
 1.10A 2xdcA-4m1rA:
undetectable
2xdcB-4m1rA:
undetectable		 2xdcA-4m1rA:
4.56
2xdcB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  51
TRP A  46
 None
 1.06A 2xdcC-4m1rA:
undetectable
2xdcD-4m1rA:
undetectable		 2xdcC-4m1rA:
4.56
2xdcD-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 284
SER A 223
ALA A 288
GLY A 285
ALA A 265
 None
 1.06A 2xh9A-4m1rA:
undetectable		 2xh9A-4m1rA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 10 SER A 284
SER A 223
ALA A 288
GLY A 285
ALA A 265
 None
 1.09A 2xh9B-4m1rA:
undetectable		 2xh9B-4m1rA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  46
TRP A  51
 None
 1.08A 2y5mA-4m1rA:
undetectable
2y5mB-4m1rA:
undetectable		 2y5mA-4m1rA:
4.56
2y5mB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  51
TRP A  46
 None
 0.94A 2y5mA-4m1rA:
undetectable
2y5mB-4m1rA:
undetectable		 2y5mA-4m1rA:
4.56
2y5mB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  46
TRP A  51
 None
 1.09A 2y6nA-4m1rA:
undetectable
2y6nB-4m1rA:
undetectable		 2y6nA-4m1rA:
4.56
2y6nB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  51
TRP A  46
 None
 0.94A 2y6nA-4m1rA:
undetectable
2y6nB-4m1rA:
undetectable		 2y6nA-4m1rA:
4.56
2y6nB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 TRP A  46
VAL A  44
TRP A  51
 None
 0.95A 2y6nA-4m1rA:
undetectable
2y6nB-4m1rA:
undetectable		 2y6nA-4m1rA:
4.56
2y6nB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 TRP A  51
VAL A  44
TRP A  46
 None
 1.08A 2y6nA-4m1rA:
undetectable
2y6nB-4m1rA:
undetectable		 2y6nA-4m1rA:
4.56
2y6nB-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 HIS A  97
PHE A 111
PHE A 112
 TRS  A 301 (-3.9A)
None
None
 0.45A 3lk0D-4m1rA:
undetectable		 3lk0D-4m1rA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.15A 3mg0H-4m1rA:
undetectable
3mg0I-4m1rA:
undetectable		 3mg0H-4m1rA:
22.83
3mg0I-4m1rA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.16A 3mg0V-4m1rA:
undetectable
3mg0W-4m1rA:
undetectable		 3mg0V-4m1rA:
22.83
3mg0W-4m1rA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 ARG A  57
ILE A  93
ILE A 150
ALA A 185
TYR A 184
 None
 1.20A 3ohtA-4m1rA:
undetectable
3ohtB-4m1rA:
undetectable		 3ohtA-4m1rA:
19.49
3ohtB-4m1rA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 5 ASN A  74
ASP A  63
GLU A 102
SER A  29
 None
 1.42A 3p2kC-4m1rA:
2.0		 3p2kC-4m1rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 ARG A  57
GLU A 128
TYR A 194
ASN A 131
HIS A  97
 None
None
None
TRS  A 301 (-3.3A)
TRS  A 301 (-3.9A)
 1.48A 3w2tB-4m1rA:
undetectable		 3w2tB-4m1rA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  46
TRP A  51
 None
 1.35A 3zq8A-4m1rA:
undetectable
3zq8B-4m1rA:
undetectable		 3zq8A-4m1rA:
4.56
3zq8B-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4m1r CELLULASE 5
(soil
metagenome) 		3 / 3 VAL A  44
TRP A  51
TRP A  46
 None
 0.99A 3zq8A-4m1rA:
undetectable
3zq8B-4m1rA:
undetectable		 3zq8A-4m1rA:
4.56
3zq8B-4m1rA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 6 HIS A 192
GLU A 220
ASP A  95
SER A  25
 None
TRS  A 301 (-2.7A)
None
None
 1.06A 4apjA-4m1rA:
undetectable
4apjP-4m1rA:
undetectable		 4apjA-4m1rA:
17.92
4apjP-4m1rA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 GLY A  61
GLY A  66
VAL A  62
ASN A 131
SER A  29
 None
None
None
TRS  A 301 (-3.3A)
None
 1.16A 4f84A-4m1rA:
undetectable		 4f84A-4m1rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 9 ASN A 225
GLY A 229
GLY A 230
GLY A 228
ASP A 227
 None
 1.13A 4h2fA-4m1rA:
1.9		 4h2fA-4m1rA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 9 ASN A 225
GLY A 229
GLY A 230
GLY A 228
ASP A 227
 None
 1.08A 4h2gA-4m1rA:
2.4		 4h2gA-4m1rA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 5 ASN A 131
HIS A  97
GLU A 128
THR A 219
 TRS  A 301 (-3.3A)
TRS  A 301 (-3.9A)
None
None
 1.43A 4p6sA-4m1rA:
undetectable		 4p6sA-4m1rA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 5 THR A 237
THR A 234
THR A 282
ASN A 253
 None
 1.25A 4pgfB-4m1rA:
undetectable		 4pgfB-4m1rA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 10 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.25A 4qvlV-4m1rA:
0.0
4qvlW-4m1rA:
0.0		 4qvlV-4m1rA:
22.19
4qvlW-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.14A 4qvpH-4m1rA:
undetectable
4qvpI-4m1rA:
undetectable		 4qvpH-4m1rA:
22.19
4qvpI-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.14A 4qvpV-4m1rA:
undetectable
4qvpW-4m1rA:
undetectable		 4qvpV-4m1rA:
22.19
4qvpW-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.25A 4qvpV-4m1rA:
undetectable
4qvpW-4m1rA:
undetectable		 4qvpV-4m1rA:
22.19
4qvpW-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.13A 4qvvH-4m1rA:
undetectable		 4qvvH-4m1rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.13A 4qvvV-4m1rA:
undetectable		 4qvvV-4m1rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.25A 4qvyV-4m1rA:
undetectable
4qvyW-4m1rA:
undetectable		 4qvyV-4m1rA:
22.19
4qvyW-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.13A 4qw0H-4m1rA:
undetectable
4qw0I-4m1rA:
undetectable		 4qw0H-4m1rA:
22.19
4qw0I-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.25A 4qw0H-4m1rA:
undetectable
4qw0I-4m1rA:
undetectable		 4qw0H-4m1rA:
22.19
4qw0I-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.13A 4qw0V-4m1rA:
undetectable
4qw0W-4m1rA:
undetectable		 4qw0V-4m1rA:
22.19
4qw0W-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.25A 4qw0V-4m1rA:
undetectable
4qw0W-4m1rA:
undetectable		 4qw0V-4m1rA:
22.19
4qw0W-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.12A 4qw1H-4m1rA:
undetectable
4qw1I-4m1rA:
undetectable		 4qw1H-4m1rA:
22.19
4qw1I-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.23A 4qw1H-4m1rA:
undetectable
4qw1I-4m1rA:
undetectable		 4qw1H-4m1rA:
22.19
4qw1I-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
GLY A 285
THR A 286
ALA A 283
 None
 1.12A 4qw1V-4m1rA:
undetectable
4qw1W-4m1rA:
undetectable		 4qw1V-4m1rA:
22.19
4qw1W-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.23A 4qw1V-4m1rA:
undetectable
4qw1W-4m1rA:
undetectable		 4qw1V-4m1rA:
22.19
4qw1W-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 10 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.25A 4qw3H-4m1rA:
0.0
4qw3I-4m1rA:
0.3		 4qw3H-4m1rA:
22.19
4qw3I-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 11 SER A 223
ALA A 265
THR A 286
ALA A 283
THR A 282
 None
 1.25A 4qw3V-4m1rA:
undetectable
4qw3W-4m1rA:
undetectable		 4qw3V-4m1rA:
22.19
4qw3W-4m1rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4m1r CELLULASE 5
(soil
metagenome) 		6 / 12 SER A  25
GLY A 165
SER A 170
GLU A 132
ASN A 131
ALA A 146
 None
None
None
TRS  A 301 (-2.7A)
TRS  A 301 (-3.3A)
None
 1.42A 4u95B-4m1rA:
undetectable		 4u95B-4m1rA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 8 LEU A 256
THR A 282
LEU A 281
LEU A 266
 None
 0.71A 4z90F-4m1rA:
undetectable
4z90G-4m1rA:
undetectable
4z90H-4m1rA:
undetectable
4z90I-4m1rA:
undetectable
4z90J-4m1rA:
undetectable		 4z90F-4m1rA:
21.64
4z90G-4m1rA:
21.64
4z90H-4m1rA:
21.64
4z90I-4m1rA:
21.64
4z90J-4m1rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 9 SER A  25
GLY A 165
SER A 170
GLU A 132
ALA A 146
 None
None
None
TRS  A 301 (-2.7A)
None
 1.44A 5entC-4m1rA:
undetectable		 5entC-4m1rA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 ASP A  95
ALA A 101
GLY A 165
THR A 190
TYR A 194
 None
 1.20A 5igiA-4m1rA:
undetectable		 5igiA-4m1rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 7 PHE A 112
THR A 190
ILE A 129
GLY A 165
 None
 0.96A 5nzyA-4m1rA:
undetectable		 5nzyA-4m1rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 12 PHE A 193
ALA A 195
THR A 237
ALA A 288
ILE A 292
 None
 1.01A 5veuB-4m1rA:
undetectable		 5veuB-4m1rA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 7 ALA A 146
THR A 147
VAL A 164
PRO A 215
 None
 0.83A 6cduA-4m1rA:
undetectable
6cduE-4m1rA:
undetectable		 6cduA-4m1rA:
21.84
6cduE-4m1rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 6 VAL A 164
PRO A 215
ALA A 146
THR A 147
 None
 0.82A 6cduB-4m1rA:
undetectable
6cduC-4m1rA:
undetectable		 6cduB-4m1rA:
21.84
6cduC-4m1rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 7 VAL A 164
PRO A 215
ALA A 146
THR A 147
 None
 0.78A 6cduC-4m1rA:
undetectable
6cduD-4m1rA:
undetectable		 6cduC-4m1rA:
21.84
6cduD-4m1rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 7 ALA A 146
THR A 147
VAL A 164
PRO A 215
 None
 0.79A 6cduF-4m1rA:
undetectable
6cduJ-4m1rA:
undetectable		 6cduF-4m1rA:
21.84
6cduJ-4m1rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4m1r CELLULASE 5
(soil
metagenome) 		4 / 7 VAL A 164
PRO A 215
ALA A 146
THR A 147
 None
 0.86A 6cduH-4m1rA:
undetectable
6cduI-4m1rA:
undetectable		 6cduH-4m1rA:
21.84
6cduI-4m1rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4m1r CELLULASE 5
(soil
metagenome) 		5 / 9 ALA A 265
GLY A 285
LEU A 287
GLY A 228
ASN A 253
 None
 1.13A 6nm4B-4m1rA:
undetectable		 6nm4B-4m1rA:
18.69