SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 308
SER A 310
GLY A 315
PHE A 335
 None
 0.86A 1fapB-4m1zA:
undetectable		 1fapB-4m1zA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 1.17A 1hwiB-4m1zA:
undetectable		 1hwiB-4m1zA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 1.01A 1hwkA-4m1zA:
undetectable		 1hwkA-4m1zA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 1.01A 1hwkC-4m1zA:
undetectable		 1hwkC-4m1zA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 154
SER A 157
ASN A 115
ASP A 111
 None
 1.03A 1hwkD-4m1zA:
undetectable		 1hwkD-4m1zA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.89A 1mz9A-4m1zA:
undetectable		 1mz9A-4m1zA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.87A 1mz9C-4m1zA:
undetectable		 1mz9C-4m1zA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 301
LEU A 278
ILE A 130
ILE A 131
GLY A 342
 None
 0.95A 1qknA-4m1zA:
undetectable		 1qknA-4m1zA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.94A 1rs7A-4m1zA:
undetectable		 1rs7A-4m1zA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.92A 1rs7B-4m1zA:
undetectable		 1rs7B-4m1zA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A 118
MET A 117
ASP A 108
ALA A 113
ARG A 154
 None
 1.41A 2avdB-4m1zA:
undetectable		 2avdB-4m1zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.89A 2avvE-4m1zA:
undetectable		 2avvE-4m1zA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 357
ILE A 360
VAL A 226
ALA A 225
ILE A 199
 None
 0.95A 2h42B-4m1zA:
undetectable		 2h42B-4m1zA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.97A 2pymA-4m1zA:
undetectable		 2pymA-4m1zA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.96A 2pynA-4m1zA:
undetectable		 2pynA-4m1zA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 2q64A-4m1zA:
undetectable		 2q64A-4m1zA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  73
THR A 390
VAL A 386
 None
 0.94A 2q64A-4m1zA:
undetectable		 2q64A-4m1zA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 MET A 294
VAL A 382
GLU A 306
 None
 0.77A 2x9gA-4m1zA:
3.3		 2x9gA-4m1zA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.97A 3d1xB-4m1zA:
undetectable		 3d1xB-4m1zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 381
GLY A 371
GLY A 372
ILE A 383
ALA A 301
 None
 0.90A 3douA-4m1zA:
undetectable		 3douA-4m1zA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A  72
GLY A 132
ILE A 131
ALA A  68
ILE A  74
 None
 0.91A 3ekpB-4m1zA:
undetectable		 3ekpB-4m1zA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 3el1A-4m1zA:
undetectable		 3el1A-4m1zA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 363
ALA A 388
ALA A  77
LEU A 346
ILE A  74
 None
 1.06A 3gwsX-4m1zA:
undetectable		 3gwsX-4m1zA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 128
GLY A 315
ILE A 130
VAL A 318
SER A 310
 None
 1.25A 3gyqB-4m1zA:
2.2		 3gyqB-4m1zA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.93A 3k4vD-4m1zA:
undetectable		 3k4vD-4m1zA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.96A 3keeA-4m1zA:
undetectable		 3keeA-4m1zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.95A 3keeD-4m1zA:
undetectable		 3keeD-4m1zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A 280
LEU A 278
TYR A 339
VAL A 382
GLY A 379
 None
 1.14A 3ls4H-4m1zA:
undetectable		 3ls4H-4m1zA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.95A 3ndtC-4m1zA:
undetectable		 3ndtC-4m1zA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.95A 3ndtD-4m1zA:
undetectable		 3ndtD-4m1zA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.87A 3nduA-4m1zA:
undetectable		 3nduA-4m1zA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 3nduB-4m1zA:
undetectable		 3nduB-4m1zA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.90A 3nduC-4m1zA:
undetectable		 3nduC-4m1zA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.91A 3nduD-4m1zA:
undetectable		 3nduD-4m1zA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.94A 3pwrA-4m1zA:
undetectable		 3pwrA-4m1zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.98A 3sueA-4m1zA:
undetectable		 3sueA-4m1zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.91A 3sufA-4m1zA:
undetectable		 3sufA-4m1zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.98A 3sufC-4m1zA:
undetectable		 3sufC-4m1zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.93A 3tkgA-4m1zA:
undetectable		 3tkgA-4m1zA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  72
GLY A 342
GLY A 133
PRO A  66
ILE A  74
 None
 0.96A 3tkgB-4m1zA:
undetectable		 3tkgB-4m1zA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 362
PHE A 351
PRO A 352
 None
 0.81A 3zoaB-4m1zA:
undetectable		 3zoaB-4m1zA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A 143
ILE A 130
VAL A 101
SER A 310
 None
 0.93A 4kcnA-4m1zA:
undetectable		 4kcnA-4m1zA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 9 SER A 336
GLY A 305
SER A 282
SER A 293
GLY A 332
 None
 1.49A 4lb0A-4m1zA:
undetectable		 4lb0A-4m1zA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 339
ALA A 129
GLY A 133
GLY A 143
GLY A 312
 None
 1.03A 4obwB-4m1zA:
undetectable		 4obwB-4m1zA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 124
ASP A 121
ILE A 131
ASN A 200
GLY A 133
 None
 1.21A 4obwC-4m1zA:
undetectable		 4obwC-4m1zA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 119
SER A  98
GLY A 124
PHE A 141
GLY A 315
 None
 1.39A 4pevB-4m1zA:
5.3		 4pevB-4m1zA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 390
ALA A 388
THR A 366
ALA A 367
 None
 0.98A 4qw0K-4m1zA:
undetectable		 4qw0K-4m1zA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 390
ALA A 388
THR A 366
ALA A 367
 None
 0.98A 4qw0Y-4m1zA:
undetectable		 4qw0Y-4m1zA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.21A 5eypB-4m1zA:
2.7		 5eypB-4m1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 289
LEU A 278
TYR A 339
PHE A 335
 None
 1.45A 5igjA-4m1zA:
undetectable		 5igjA-4m1zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 299
SER A 295
TRP A 298
 None
 0.97A 5jwaA-4m1zA:
undetectable		 5jwaA-4m1zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 195
ALA A 231
GLY A 230
ALA A 225
ILE A 199
 None
 0.92A 5kb6B-4m1zA:
3.7		 5kb6B-4m1zA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.92A 5lf3K-4m1zA:
undetectable
5lf3L-4m1zA:
undetectable		 5lf3K-4m1zA:
22.14
5lf3L-4m1zA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.93A 5lf3Y-4m1zA:
undetectable
5lf3Z-4m1zA:
undetectable		 5lf3Y-4m1zA:
22.14
5lf3Z-4m1zA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.94A 5lf7K-4m1zA:
undetectable
5lf7L-4m1zA:
undetectable		 5lf7K-4m1zA:
22.14
5lf7L-4m1zA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.94A 5lf7Y-4m1zA:
undetectable
5lf7Z-4m1zA:
undetectable		 5lf7Y-4m1zA:
22.14
5lf7Z-4m1zA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.30A 5nm5B-4m1zA:
2.6		 5nm5B-4m1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.97A 6c2mC-4m1zA:
undetectable		 6c2mC-4m1zA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.91A 6hwdK-4m1zA:
undetectable
6hwdL-4m1zA:
undetectable		 6hwdK-4m1zA:
11.97
6hwdL-4m1zA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 367
ALA A 365
GLY A 379
GLY A 300
ALA A 301
 None
 0.91A 6hwdY-4m1zA:
undetectable
6hwdZ-4m1zA:
undetectable		 6hwdY-4m1zA:
11.97
6hwdZ-4m1zA:
13.51