SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m29'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 4 THR A 227
PRO A 201
THR A 228
PRO A 164
 None
 1.16A 1a7yA-4m29A:
undetectable
1a7yC-4m29A:
undetectable		 1a7yA-4m29A:
5.43
1a7yC-4m29A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 TRP A  83
LEU A 136
LEU A  69
GLY A  70
ALA A  63
 None
 1.09A 1hvyD-4m29A:
undetectable		 1hvyD-4m29A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 7 PHE A 338
TYR A 231
HIS A 292
VAL A 233
 None
 1.37A 1wu8A-4m29A:
undetectable
1wu8C-4m29A:
undetectable		 1wu8A-4m29A:
20.72
1wu8C-4m29A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 THR A  71
PRO A 108
PRO A  35
ILE A  86
VAL A  72
 None
 1.33A 1z9hB-4m29A:
undetectable		 1z9hB-4m29A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 THR A 203
ALA A 207
ASN A 165
VAL A 233
HIS A 229
 None
 1.39A 2gl0A-4m29A:
undetectable
2gl0C-4m29A:
undetectable		 2gl0A-4m29A:
17.43
2gl0C-4m29A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 7 ARG A  60
GLU A 159
PHE A 101
TYR A 277
 None
 1.46A 2q6uA-4m29A:
undetectable		 2q6uA-4m29A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		6 / 12 ASN A 162
GLU A 163
HIS A 229
TYR A 231
GLU A 280
TRP A 318
 None
 0.71A 2v3dA-4m29A:
20.0		 2v3dA-4m29A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		6 / 12 ASN A 162
GLU A 163
PHE A 119
HIS A 229
GLU A 280
TRP A 318
 None
 0.78A 2v3dA-4m29A:
20.0		 2v3dA-4m29A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 11 ASN A 162
GLU A 163
PHE A 119
GLU A 280
TRP A 318
 None
 0.77A 2v3dB-4m29A:
19.9		 2v3dB-4m29A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 11 ASN A 162
GLU A 163
TYR A 231
GLU A 280
TRP A 318
 None
 0.78A 2v3dB-4m29A:
19.9		 2v3dB-4m29A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 7 THR A  50
VAL A  51
ILE A  98
ILE A  59
SER A  32
 None
 1.44A 3deuA-4m29A:
undetectable		 3deuA-4m29A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 5 LEU A 357
ARG A  57
ILE A  30
PHE A  56
 None
 1.16A 3ln1D-4m29A:
undetectable		 3ln1D-4m29A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 ALA A 202
PHE A 212
THR A 185
SER A 219
THR A 203
 None
 1.20A 3nrrB-4m29A:
undetectable		 3nrrB-4m29A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 VAL A 381
VAL A 482
LEU A 484
LEU A 417
VAL A 492
 None
 1.12A 3rr3C-4m29A:
undetectable		 3rr3C-4m29A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 VAL A 381
VAL A 482
LEU A 484
LEU A 417
VAL A 492
 None
 1.12A 3rr3D-4m29A:
undetectable		 3rr3D-4m29A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		3 / 3 LYS A 348
PRO A 349
SER A 350
 None
 0.44A 4k50I-4m29A:
undetectable		 4k50I-4m29A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 ALA A 222
ALA A 188
LEU A 104
ILE A 137
PHE A 225
 None
 1.17A 4lnwA-4m29A:
undetectable		 4lnwA-4m29A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 VAL A 223
ILE A 266
VAL A 209
LEU A 213
LEU A 276
 None
 1.03A 4m11B-4m29A:
undetectable		 4m11B-4m29A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 5 ASP A 466
VAL A 491
ASP A 490
GLY A 433
 None
 1.13A 4xp6A-4m29A:
undetectable		 4xp6A-4m29A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		3 / 3 ASP A 438
ARG A 435
TYR A 295
 None
 0.79A 5a7mA-4m29A:
5.1		 5a7mA-4m29A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		3 / 3 ASP A 438
ARG A 435
TYR A 295
 None
 0.81A 5a7mB-4m29A:
5.3		 5a7mB-4m29A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 7 HIS A 143
ILE A  86
TYR A 148
ARG A 147
 None
 1.29A 5kkzC-4m29A:
undetectable
5kkzE-4m29A:
undetectable		 5kkzC-4m29A:
18.30
5kkzE-4m29A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 7 ILE A  86
TYR A 148
ARG A 147
HIS A 143
 None
 1.28A 5kkzK-4m29A:
undetectable
5kkzQ-4m29A:
undetectable		 5kkzK-4m29A:
23.08
5kkzQ-4m29A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		5 / 12 PHE A 119
THR A 319
GLY A 339
PRO A 330
GLY A 328
 None
 1.33A 5tuiB-4m29A:
undetectable		 5tuiB-4m29A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4m29 BETA-XYLOSIDASE
(Caulobacter
vibrioides) 		4 / 5 GLY A  55
ASN A 358
ASP A  27
ARG A  24
 None
 1.40A 6dwdB-4m29A:
undetectable
6dwdD-4m29A:
undetectable		 6dwdB-4m29A:
21.77
6dwdD-4m29A:
21.77