SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		4 / 7 LEU A 254
LEU A 185
TYR A 244
LEU A 198
 None
 1.06A 1kt3A-4m2gA:
undetectable		 1kt3A-4m2gA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 9 ARG A  47
ARG A  51
LEU A  29
GLU A  28
ALA A  31
 None
 1.49A 1mj2A-4m2gA:
undetectable		 1mj2A-4m2gA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		4 / 8 THR A 180
LEU A 294
VAL A  73
THR A   9
 SIN  A 402 (-3.0A)
None
None
None
 1.11A 1uyuB-4m2gA:
undetectable		 1uyuB-4m2gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		3 / 3 LEU A  60
PHE A  59
ARG A  68
 None
 0.85A 1xdkF-4m2gA:
undetectable		 1xdkF-4m2gA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		3 / 3 TRP A  91
ARG A  94
PHE A 133
 None
 1.41A 1zeaH-4m2gA:
undetectable
1zeaL-4m2gA:
undetectable		 1zeaH-4m2gA:
18.28
1zeaL-4m2gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 12 HIS A 211
ARG A 341
THR A 122
GLN A 123
SER A 164
 None
 1.13A 2fj1A-4m2gA:
undetectable		 2fj1A-4m2gA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		3 / 3 SER A 147
ASP A 176
ASP A 316
 None
 0.70A 2plwA-4m2gA:
undetectable		 2plwA-4m2gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 8 LEU A 106
VAL A 293
GLY A 170
GLY A 291
GLN A 290
 None
 1.09A 2wd9B-4m2gA:
undetectable		 2wd9B-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 10 LEU A 106
VAL A 293
GLY A 170
GLY A 291
GLN A 290
 None
 1.12A 2wd9C-4m2gA:
undetectable		 2wd9C-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		4 / 8 HIS A 204
ARG A 237
ILE A 234
PRO A 207
 None
 0.86A 3fxrA-4m2gA:
undetectable		 3fxrA-4m2gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_A_CHDA2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 9 LEU A 275
ARG A 253
PRO A 262
GLY A 240
PRO A 201
 None
 1.44A 3hcpA-4m2gA:
0.0		 3hcpA-4m2gA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		4 / 4 GLN A  81
GLN A 290
GLY A 291
HIS A  77
 None
 1.24A 3huoA-4m2gA:
undetectable		 3huoA-4m2gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		3 / 3 THR A 152
ASP A 255
GLU A 156
 None
None
FE  A 401 (-2.4A)
 0.77A 3qowA-4m2gA:
undetectable		 3qowA-4m2gA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		4 / 7 ILE A 168
LYS A   9
PHE A  63
GLY A  70
 None
 1.17A 3sj0X-4m2gA:
undetectable		 3sj0X-4m2gA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 9 ILE A 168
LEU A 114
ILE A  74
PHE A  63
GLY A  70
 None
 1.43A 3sj4X-4m2gA:
undetectable		 3sj4X-4m2gA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 9 ILE A 168
LEU A 114
LYS A   9
PHE A  63
GLY A  70
 None
 1.26A 3sj4X-4m2gA:
undetectable		 3sj4X-4m2gA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		4 / 4 PHE A 159
TYR A 162
ARG A 300
LEU A 254
 None
 1.17A 3sueA-4m2gA:
undetectable		 3sueA-4m2gA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 9 LEU A 113
VAL A 293
ILE A  74
LEU A  14
GLY A  55
 None
 1.01A 4kukA-4m2gA:
undetectable		 4kukA-4m2gA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		3 / 3 GLN A 123
SER A 164
ASP A 157
 None
 0.91A 4qwpA-4m2gA:
undetectable
4qwpB-4m2gA:
undetectable		 4qwpA-4m2gA:
22.59
4qwpB-4m2gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		3 / 3 THR A 152
ASP A 255
GLU A 156
 None
None
FE  A 401 (-2.4A)
 0.65A 5fa8A-4m2gA:
undetectable		 5fa8A-4m2gA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 12 ARG A 270
VAL A 261
LEU A 243
VAL A 197
ALA A 271
 None
 1.06A 5ikqA-4m2gA:
undetectable		 5ikqA-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 12 ARG A 270
VAL A 261
LEU A 243
VAL A 197
ALA A 271
 None
 1.05A 5iktA-4m2gA:
undetectable		 5iktA-4m2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		5 / 12 LEU A 328
ARG A 330
SER A 331
LEU A 343
PRO A 161
 None
 1.39A 5uahC-4m2gA:
undetectable		 5uahC-4m2gA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4m2g L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
lavendulae) 		3 / 3 LYS A 320
VAL A 129
ASP A 131
 None
 0.45A 6fgdA-4m2gA:
undetectable		 6fgdA-4m2gA:
22.87