SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_E_MTXE2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	4m3k	CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S (Lama glama)	5 / 12	SER B 29 MET B 34 ARG B 71 VAL B 78 ALA B 97	None	1.24A	3qxvE-4m3kB: 15.1	3qxvE-4m3kB: 68.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X5Q_C_D16C402_1 (THYMIDYLATE SYNTHASE)	4m3k	CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S (Lama glama)	4 / 7	PHE B 98 LEU B 50 GLY B 35 TYR B 59	None	0.88A	5x5qC-4m3kB: undetectable	5x5qC-4m3kB: 16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X5Q_E_D16E402_1 (THYMIDYLATE SYNTHASE)	4m3k	CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S (Lama glama)	4 / 6	PHE B 98 LEU B 50 GLY B 35 TYR B 59	None	0.88A	5x5qE-4m3kB: undetectable	5x5qE-4m3kB: 16.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6CJK_B_ACTB302_0 (IMMUNOGLOBULIN FAB HEAVY CHAIN)	4m3k	CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S (Lama glama)	3 / 3	TYR B 59 GLY B 65 THR B 68	None	0.17A	6cjkB-4m3kB: 16.8	6cjkB-4m3kB: 31.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3QXV_E_MTXE2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","4m3k","CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S","Lama glama",5,"SER B  29;MET B  34;ARG B  71;VAL B  78;ALA B  97","None","1.24A","3qxvE-4m3kB:15.1","3qxvE-4m3kB:68.55"],["5X5Q_C_D16C402_1","THYMIDYLATE SYNTHASE","4m3k","CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S","Lama glama",4,"PHE B  98;LEU B  50;GLY B  35;TYR B  59","None","0.88A","5x5qC-4m3kB:undetectable","5x5qC-4m3kB:16.38"],["5X5Q_E_D16E402_1","THYMIDYLATE SYNTHASE","4m3k","CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S","Lama glama",4,"PHE B  98;LEU B  50;GLY B  35;TYR B  59","None","0.88A","5x5qE-4m3kB:undetectable","5x5qE-4m3kB:16.38"],["6CJK_B_ACTB302_0","IMMUNOGLOBULIN FAB HEAVY CHAIN","4m3k","CAMELID HEAVY-CHAIN ANTIBODY VARIABLE FRAGMENT CAB-H7S","Lama glama",3,"TYR B  59;GLY B  65;THR B  68","None","0.17A","6cjkB-4m3kB:16.8","6cjkB-4m3kB:31.60"]]