SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 THR A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.47A 1jdvA-4m3nA:
34.3
1jdvD-4m3nA:
34.4
1jdvA-4m3nA:
32.57
1jdvD-4m3nA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 THR A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.44A 1jdvB-4m3nA:
34.4
1jdvC-4m3nA:
35.4
1jdvB-4m3nA:
32.57
1jdvC-4m3nA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 THR A  90
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.48A 1jdvA-4m3nA:
34.3
1jdvD-4m3nA:
34.4
1jdvA-4m3nA:
32.57
1jdvD-4m3nA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 12 THR A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.51A 1jdvE-4m3nA:
34.5
1jdvF-4m3nA:
35.5
1jdvE-4m3nA:
32.57
1jdvF-4m3nA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 THR A  90
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.91A 1jdvE-4m3nA:
34.5
1jdvF-4m3nA:
35.5
1jdvE-4m3nA:
32.57
1jdvF-4m3nA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.63A 1odiA-4m3nA:
25.1
1odiA-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 THR A  90
GLY A  92
GLU A 179
GLU A 181
ILE A  94
None
1.37A 1odiA-4m3nA:
25.1
1odiA-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.65A 1odiB-4m3nA:
35.5
1odiB-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 THR A  90
GLY A  92
GLU A 179
GLU A 181
ILE A  94
None
1.33A 1odiB-4m3nA:
35.5
1odiB-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.63A 1odiC-4m3nA:
35.6
1odiC-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 THR A  90
GLY A  92
GLU A 179
GLU A 181
ILE A  94
None
1.28A 1odiC-4m3nA:
35.6
1odiC-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.67A 1odiD-4m3nA:
35.5
1odiD-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 THR A  90
GLY A  92
GLU A 179
GLU A 181
ILE A  94
None
1.36A 1odiD-4m3nA:
35.5
1odiD-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.58A 1odiE-4m3nA:
35.5
1odiE-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 THR A  90
GLY A  92
GLU A 179
GLU A 181
ILE A  94
None
1.34A 1odiE-4m3nA:
35.5
1odiE-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.62A 1odiF-4m3nA:
35.6
1odiF-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 THR A  90
GLY A  92
GLU A 179
GLU A 181
ILE A  94
None
1.37A 1odiF-4m3nA:
35.6
1odiF-4m3nA:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.72A 1pk7A-4m3nA:
37.9
1pk7A-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.81A 1pk7A-4m3nA:
37.9
1pk7A-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.36A 1pk7A-4m3nA:
37.9
1pk7A-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 MET A  64
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.92A 1pk7C-4m3nA:
38.0
1pk7C-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 10 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.57A 1pk7C-4m3nA:
38.0
1pk7C-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.77A 1pk9A-4m3nA:
37.6
1pk9A-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 10 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.37A 1pk9A-4m3nA:
37.6
1pk9A-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 MET A  64
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.90A 1pk9A-4m3nA:
37.6
1pk9A-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.80A 1pk9B-4m3nA:
38.0
1pk9B-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.82A 1pk9B-4m3nA:
38.0
1pk9B-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.39A 1pk9B-4m3nA:
38.0
1pk9B-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A  94
None
1.46A 1pk9C-4m3nA:
36.6
1pk9C-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.56A 1pk9C-4m3nA:
36.6
1pk9C-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 GLY A  92
GLU A 179
MET A 180
GLU A 181
ILE A  94
None
1.42A 1pw7A-4m3nA:
37.8
1pw7A-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.78A 1pw7A-4m3nA:
37.8
1pw7A-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 MET A  64
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.82A 1pw7A-4m3nA:
37.8
1pw7A-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 MET A  64
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.35A 1pw7A-4m3nA:
37.8
1pw7A-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A  94
None
1.48A 1pw7B-4m3nA:
38.4
1pw7B-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.74A 1pw7B-4m3nA:
38.4
1pw7B-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.26A 1pw7B-4m3nA:
38.4
1pw7B-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.87A 1pw7C-4m3nA:
38.2
1pw7C-4m3nA:
48.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.48A 1pw7C-4m3nA:
38.2
1pw7C-4m3nA:
48.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
4 / 7 LYS A  26
LEU A  23
GLU A  30
ALA A  25
None
1.13A 1sn0B-4m3nA:
undetectable
1sn0D-4m3nA:
undetectable
1sn0B-4m3nA:
18.75
1sn0D-4m3nA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A  94
None
1.46A 1vhwA-4m3nA:
38.5
1vhwD-4m3nA:
38.5
1vhwA-4m3nA:
49.06
1vhwD-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.22A 1vhwA-4m3nA:
38.5
1vhwD-4m3nA:
38.5
1vhwA-4m3nA:
49.06
1vhwD-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
GLY A  92
VAL A 178
MET A 180
GLU A 181
None
0.25A 1vhwB-4m3nA:
39.0
1vhwF-4m3nA:
38.5
1vhwB-4m3nA:
49.06
1vhwF-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.86A 1vhwC-4m3nA:
38.5
1vhwE-4m3nA:
38.6
1vhwC-4m3nA:
49.06
1vhwE-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.24A 1vhwC-4m3nA:
38.5
1vhwE-4m3nA:
38.6
1vhwC-4m3nA:
49.06
1vhwE-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 11 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.85A 1vhwA-4m3nA:
38.5
1vhwD-4m3nA:
38.5
1vhwA-4m3nA:
49.06
1vhwD-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.24A 1vhwA-4m3nA:
38.5
1vhwD-4m3nA:
38.5
1vhwA-4m3nA:
49.06
1vhwD-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ILE A  94
None
1.46A 1vhwC-4m3nA:
38.5
1vhwE-4m3nA:
38.6
1vhwC-4m3nA:
49.06
1vhwE-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.22A 1vhwC-4m3nA:
38.5
1vhwE-4m3nA:
38.6
1vhwC-4m3nA:
49.06
1vhwE-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.24A 1vhwB-4m3nA:
39.0
1vhwF-4m3nA:
38.5
1vhwB-4m3nA:
49.06
1vhwF-4m3nA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 10 MET A  64
ARG A  87
THR A  90
THR A 156
GLU A 179
MET A 180
GLU A 181
None
0.80A 1z35A-4m3nA:
36.4
1z35A-4m3nA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
9 / 10 MET A  64
THR A  90
GLY A  92
THR A 156
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.36A 1z35A-4m3nA:
36.4
1z35A-4m3nA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
ARG A  87
THR A  90
MET A 180
GLU A 181
None
0.92A 1z37A-4m3nA:
36.3
1z37A-4m3nA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
8 / 9 MET A  64
THR A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.43A 1z37A-4m3nA:
36.3
1z37A-4m3nA:
50.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
4 / 7 VAL A  88
GLY A  89
THR A 201
ASP A 222
None
0.82A 2a1mA-4m3nA:
undetectable
2a1mA-4m3nA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.54A 2ac7A-4m3nA:
38.3
2ac7B-4m3nA:
38.4
2ac7A-4m3nA:
56.08
2ac7B-4m3nA:
56.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
THR A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.56A 2ac7A-4m3nA:
38.3
2ac7B-4m3nA:
38.4
2ac7A-4m3nA:
56.08
2ac7B-4m3nA:
56.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
3 / 3 PRO A 127
ASN A 116
ARG A 119
None
1.00A 2qeuB-4m3nA:
undetectable
2qeuB-4m3nA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 ALA A 109
SER A  70
ILE A  73
LEU A  85
TYR A 125
None
1.28A 3ia4A-4m3nA:
undetectable
3ia4A-4m3nA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 ALA A 109
SER A  70
ILE A  73
LEU A  85
TYR A 125
None
1.27A 3ia4B-4m3nA:
undetectable
3ia4B-4m3nA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 ALA A 109
SER A  70
ILE A  73
LEU A  85
TYR A 125
None
1.29A 3ia4C-4m3nA:
undetectable
3ia4C-4m3nA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.35A 3u40A-4m3nA:
37.3
3u40F-4m3nA:
15.8
3u40A-4m3nA:
47.15
3u40F-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 MET A  64
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.36A 3u40B-4m3nA:
20.0
3u40C-4m3nA:
36.4
3u40B-4m3nA:
47.15
3u40C-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.34A 3u40B-4m3nA:
20.0
3u40C-4m3nA:
36.4
3u40B-4m3nA:
47.15
3u40C-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.35A 3u40D-4m3nA:
37.2
3u40E-4m3nA:
36.2
3u40D-4m3nA:
47.15
3u40E-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
None
0.75A 3u40D-4m3nA:
37.2
3u40E-4m3nA:
36.2
3u40D-4m3nA:
47.15
3u40E-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.34A 3u40D-4m3nA:
37.2
3u40E-4m3nA:
36.2
3u40D-4m3nA:
47.15
3u40E-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 MET A  64
GLU A 179
MET A 180
GLU A 181
ASP A 204
None
0.54A 3u40A-4m3nA:
37.3
3u40F-4m3nA:
15.8
3u40A-4m3nA:
47.15
3u40F-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 10 MET A  64
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.32A 3u40A-4m3nA:
37.3
3u40F-4m3nA:
15.8
3u40A-4m3nA:
47.15
3u40F-4m3nA:
47.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
8 / 11 MET A  64
THR A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.61A 3uawA-4m3nA:
39.2
3uawA-4m3nA:
56.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 THR A  90
GLY A  92
VAL A 178
GLU A 179
GLU A 181
ILE A  94
None
1.46A 3uawA-4m3nA:
39.2
3uawA-4m3nA:
56.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 10 MET A  64
THR A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.48A 3uayA-4m3nA:
21.8
3uayA-4m3nA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 THR A  90
GLY A  92
VAL A 178
GLU A 179
GLU A 181
ILE A  94
None
1.48A 3uayA-4m3nA:
21.8
3uayA-4m3nA:
55.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 VAL A 153
LEU A 154
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.29A 4coxC-4m3nA:
undetectable
4coxC-4m3nA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
ASP A 204
None
1.02A 4d9hA-4m3nA:
39.2
4d9hA-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.89A 4d9hA-4m3nA:
39.2
4d9hA-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.43A 4d9hA-4m3nA:
39.2
4d9hA-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 MET A  64
GLY A  92
MET A 180
GLU A 181
SER A 203
ASP A 204
None
1.13A 4da6A-4m3nA:
39.2
4da6A-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
GLY A  92
VAL A 178
MET A 180
GLU A 181
None
0.44A 4da6A-4m3nA:
39.2
4da6A-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 MET A  64
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.57A 4da7A-4m3nA:
39.2
4da7A-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.44A 4da7A-4m3nA:
39.2
4da7A-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
ARG A  87
GLU A 179
MET A 180
GLU A 181
ASP A 204
None
0.98A 4danA-4m3nA:
39.1
4danA-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.99A 4danA-4m3nA:
39.1
4danA-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.39A 4danA-4m3nA:
39.1
4danA-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ASP A 204
None
0.99A 4danA-4m3nA:
39.1
4danB-4m3nA:
39.0
4danA-4m3nA:
54.26
4danB-4m3nA:
54.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.42A 4danA-4m3nA:
39.1
4danB-4m3nA:
39.0
4danA-4m3nA:
54.26
4danB-4m3nA:
54.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
4 / 4 LEU A 188
ALA A  69
ILE A  66
LYS A 191
None
1.42A 4eixA-4m3nA:
undetectable
4eixA-4m3nA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 VAL A 153
LEU A 154
LEU A 206
GLY A  92
ALA A  91
LEU A 200
None
1.42A 4otyA-4m3nA:
undetectable
4otyA-4m3nA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 VAL A 153
LEU A 154
LEU A 206
GLY A  92
ALA A  91
LEU A 200
None
1.41A 4otyB-4m3nA:
undetectable
4otyB-4m3nA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 VAL A 153
LEU A 154
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.27A 4otyB-4m3nA:
undetectable
4otyB-4m3nA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.07A 4rrwA-4m3nA:
undetectable
4rrwA-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.06A 4rrwB-4m3nA:
undetectable
4rrwB-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.09A 4rrwC-4m3nA:
undetectable
4rrwC-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 VAL A 153
LEU A 154
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.24A 4rrwD-4m3nA:
undetectable
4rrwD-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.07A 4rrzA-4m3nA:
undetectable
4rrzA-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.06A 4rrzB-4m3nA:
undetectable
4rrzB-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.09A 4rrzC-4m3nA:
undetectable
4rrzC-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 12 VAL A 153
LEU A 154
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.24A 4rrzD-4m3nA:
undetectable
4rrzD-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 9 VAL A 153
LEU A 154
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.22A 4rs0A-4m3nA:
undetectable
4rs0A-4m3nA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 GLY A  20
TYR A  27
TYR A  72
ALA A  69
ASP A  21
None
1.26A 4ymgB-4m3nA:
undetectable
4ymgB-4m3nA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
4 / 8 ALA A 177
HIS A 149
HIS A 205
THR A  95
None
1.24A 5db5A-4m3nA:
undetectable
5db5B-4m3nA:
undetectable
5db5A-4m3nA:
18.31
5db5B-4m3nA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 9 MET A  64
GLY A  92
VAL A 178
MET A 180
GLU A 181
None
0.26A 5i3cA-4m3nA:
37.8
5i3cA-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
6 / 10 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
None
0.31A 5i3cB-4m3nA:
19.9
5i3cB-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
ASP A 204
None
0.73A 5i3cC-4m3nA:
37.9
5i3cC-4m3nA:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
7 / 11 MET A  64
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
None
0.41A 5i3cC-4m3nA:
37.9
5i3cC-4m3nA:
52.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.12A 5ikrA-4m3nA:
undetectable
5ikrA-4m3nA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.11A 5jvzB-4m3nA:
undetectable
5jvzB-4m3nA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
5 / 12 VAL A 153
SER A 155
GLY A  92
ALA A  91
LEU A 200
None
1.04A 5kirB-4m3nA:
undetectable
5kirB-4m3nA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Meiothermus
ruber)
3 / 3 ARG A 136
LYS A  53
ARG A 135
None
MG  A 501 ( 4.9A)
None
1.40A 6az3C-4m3nA:
undetectable
6az3L-4m3nA:
undetectable
6az3M-4m3nA:
undetectable
6az3C-4m3nA:
17.52
6az3L-4m3nA:
18.27
6az3M-4m3nA:
11.84