SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 9 GLY A  23
ALA A  22
LEU A  96
PHE A 219
LEU A 194
 None
 1.05A 1y7iA-4m46A:
3.2		 1y7iA-4m46A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		3 / 3 PHE A  57
CYH A  61
PHE A  97
 None
 0.73A 3cr5X-4m46A:
undetectable		 3cr5X-4m46A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		3 / 3 SER A 163
GLN A 162
PHE A 167
 None
 0.81A 3g4lC-4m46A:
undetectable		 3g4lC-4m46A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 11 GLY A 316
GLY A 341
ARG A 337
ALA A 313
GLU A 311
 None
 0.95A 3g88A-4m46A:
3.2		 3g88A-4m46A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 11 GLY A 316
GLY A 341
ARG A 337
ALA A 313
GLU A 311
 None
 0.96A 3g88B-4m46A:
3.2		 3g88B-4m46A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 12 GLY A 316
GLY A 341
ARG A 337
ALA A 313
GLU A 311
 None
 1.08A 3g89A-4m46A:
2.9		 3g89A-4m46A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 11 GLY A 316
GLY A 341
ARG A 337
ALA A 313
GLU A 311
 None
 0.92A 3g89B-4m46A:
undetectable		 3g89B-4m46A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 12 GLY A 316
GLY A 341
ARG A 337
ALA A 313
GLU A 311
 None
 0.95A 3g8bA-4m46A:
undetectable		 3g8bA-4m46A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 12 GLY A 316
GLY A 341
ARG A 337
ALA A 313
GLU A 311
 None
 0.88A 3g8bB-4m46A:
undetectable		 3g8bB-4m46A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 4 LEU A  86
MET A  30
ILE A 282
ASP A 234
 None
 1.47A 3hecA-4m46A:
undetectable		 3hecA-4m46A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 6 LEU A 253
PHE A 250
ILE A 215
PHE A 368
 None
 0.97A 3ko0B-4m46A:
undetectable		 3ko0B-4m46A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 6 LEU A 253
PHE A 250
ILE A 215
PHE A 368
 None
 1.01A 3ko0S-4m46A:
undetectable		 3ko0S-4m46A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 5 ILE A 397
THR A 345
THR A 346
PHE A 369
 None
 0.95A 3snfA-4m46A:
undetectable		 3snfA-4m46A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		3 / 3 ARG A 337
ARG A 218
ASP A 224
 None
 0.93A 3wipG-4m46A:
undetectable
3wipH-4m46A:
undetectable		 3wipG-4m46A:
16.55
3wipH-4m46A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 6 ILE A 241
PRO A 242
PHE A 243
PHE A  89
 None
 0.92A 4fgkA-4m46A:
3.4		 4fgkA-4m46A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		3 / 3 SER A 347
MET A 396
ASP A 422
 None
 0.83A 4mm4B-4m46A:
undetectable		 4mm4B-4m46A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 6 LEU A 309
THR A 235
LEU A 277
SER A 276
 None
 1.04A 4pwjA-4m46A:
undetectable		 4pwjA-4m46A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 11 GLY A 339
GLY A 316
GLY A 360
ILE A 336
PHE A 292
 None
 1.17A 4qoiA-4m46A:
3.5
4qoiB-4m46A:
3.9		 4qoiA-4m46A:
17.85
4qoiB-4m46A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 11 GLY A 339
GLY A 316
ILE A 351
GLY A 360
PHE A 292
 None
 1.09A 4qoiA-4m46A:
3.5
4qoiB-4m46A:
3.9		 4qoiA-4m46A:
17.85
4qoiB-4m46A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 11 GLY A 363
PHE A 432
LEU A 390
ALA A 371
PHE A 227
 None
 1.22A 4wnuA-4m46A:
undetectable		 4wnuA-4m46A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 12 LEU A 253
LEU A 194
MET A 196
ARG A 218
ILE A 215
 None
 1.10A 4x1gA-4m46A:
undetectable		 4x1gA-4m46A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		3 / 3 LEU A 286
PHE A 273
ILE A 312
 None
 0.76A 5dzk1-4m46A:
undetectable
5dzkF-4m46A:
undetectable
5dzkM-4m46A:
undetectable		 5dzk1-4m46A:
0.34
5dzkF-4m46A:
17.90
5dzkM-4m46A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 8 ILE A 434
GLY A 341
THR A 345
LEU A 418
 None
 0.92A 5esjA-4m46A:
undetectable		 5esjA-4m46A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 None
 0.96A 5esmA-4m46A:
undetectable		 5esmA-4m46A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 6 VAL A 102
LEU A 194
CYH A  93
LEU A 253
 None
 1.10A 5hrqB-4m46A:
undetectable
5hrqI-4m46A:
undetectable
5hrqJ-4m46A:
undetectable		 5hrqB-4m46A:
7.34
5hrqI-4m46A:
4.00
5hrqJ-4m46A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		3 / 3 VAL A 366
SER A 347
MET A 398
 None
 0.78A 5ikqA-4m46A:
undetectable		 5ikqA-4m46A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		5 / 12 GLY A 228
HIS A 221
VAL A 366
ILE A 336
ALA A 313
 None
 1.05A 5n0tA-4m46A:
undetectable		 5n0tA-4m46A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 4m46 LUCIFERASE
(Lampyris
turkestanicus) 		4 / 6 ASN A 229
CYH A 222
PHE A 260
LEU A 286
 None
 1.42A 6a7pB-4m46A:
undetectable		 6a7pB-4m46A:
21.33