SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		3 / 3 ILE A 255
PHE A 235
HIS A 252
 None
 0.76A 3h0aA-4m47A:
1.4		 3h0aA-4m47A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 10 THR A 225
GLY A 237
PHE A 146
LEU A 228
ILE A 138
 None
 1.12A 3kvrA-4m47A:
undetectable		 3kvrA-4m47A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 10 THR A 225
GLY A 237
PHE A 146
LEU A 228
ILE A 138
 None
 1.24A 3kvrB-4m47A:
undetectable		 3kvrB-4m47A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		3 / 3 GLY A  14
THR A  16
ASN A  12
 None
 0.67A 3v4tD-4m47A:
undetectable		 3v4tD-4m47A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 11 ALA A 175
LEU A 195
PHE A 223
VAL A 221
ILE A 161
 None
 1.25A 4claA-4m47A:
undetectable		 4claA-4m47A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 12 GLY A 144
ASP A 145
PRO A 251
ILE A 150
GLU A 154
 None
 1.03A 5bw4A-4m47A:
undetectable		 5bw4A-4m47A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		4 / 5 GLY A 179
ARG A 333
ASP A 192
MET A 191
 XG4  A 401 (-3.1A)
None
MG  A 402 (-2.4A)
None
 1.41A 5ubbA-4m47A:
undetectable		 5ubbA-4m47A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 10 LEU A 100
SER A  96
ASP A  91
ILE A 119
GLY A 118
 None
 1.36A 6dlzA-4m47A:
undetectable
6dlzD-4m47A:
3.1		 6dlzA-4m47A:
11.73
6dlzD-4m47A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 10 ILE A 119
GLY A 118
LEU A 100
SER A  96
ASP A  91
 None
 1.36A 6dlzB-4m47A:
3.1
6dlzC-4m47A:
undetectable		 6dlzB-4m47A:
11.73
6dlzC-4m47A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 10 LEU A 100
SER A  96
ASP A  91
ILE A 119
GLY A 118
 None
 1.36A 6dm1A-4m47A:
undetectable
6dm1D-4m47A:
3.1		 6dm1A-4m47A:
11.73
6dm1D-4m47A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4m47 DNA POLYMERASE BETA
(Homo
sapiens) 		5 / 10 ILE A 119
GLY A 118
LEU A 100
SER A  96
ASP A  91
 None
 1.36A 6dm1B-4m47A:
3.1
6dm1C-4m47A:
undetectable		 6dm1B-4m47A:
11.73
6dm1C-4m47A:
11.73