SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 9 LEU A 339
ILE A 364
PHE A 419
VAL A 409
LEU A 428
 None
 1.19A 1e7aB-4m4dA:
undetectable		 1e7aB-4m4dA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		3 / 3 GLU A 186
HIS A 182
ASP A 165
 None
 0.86A 1i9gA-4m4dA:
undetectable		 1i9gA-4m4dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 12 GLY A  46
VAL A 154
LEU A 103
SER A 102
LEU A 144
 PC1  A 506 (-3.4A)
None
PC1  A 506 (-4.8A)
None
None
 1.05A 1ya4C-4m4dA:
undetectable		 1ya4C-4m4dA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 12 LEU A 339
ILE A 364
PHE A 419
VAL A 409
LEU A 428
 None
 1.15A 2bxeB-4m4dA:
undetectable		 2bxeB-4m4dA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 9 LEU A 144
PRO A 152
LEU A 232
LEU A 216
PHE A 247
 None
None
None
PC1  A 506 (-4.2A)
None
 1.28A 2vcvE-4m4dA:
undetectable		 2vcvE-4m4dA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 12 LEU A  50
GLY A  46
ILE A 201
ALA A 104
ASP A 141
 PC1  A 506 ( 4.5A)
PC1  A 506 (-3.4A)
None
None
None
 1.02A 3gwwA-4m4dA:
undetectable		 3gwwA-4m4dA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 12 PHE A 469
ILE A 348
LEU A 391
VAL A 398
LEU A 472
 None
 1.10A 3gwxB-4m4dA:
undetectable		 3gwxB-4m4dA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 10 PHE A 424
PHE A 321
PHE A 301
VAL A 383
TYR A 431
 None
 1.27A 3r6wA-4m4dA:
undetectable
3r6wB-4m4dA:
undetectable		 3r6wA-4m4dA:
19.18
3r6wB-4m4dA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 12 PHE A 321
ALA A 320
TYR A 431
LEU A 308
LEU A 339
 None
 1.34A 4qztC-4m4dA:
2.7		 4qztC-4m4dA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 12 TYR A 212
LEU A 144
PRO A 236
LEU A 101
ALA A  42
 PC1  A 506 (-3.7A)
None
None
None
PC1  A 506 (-3.6A)
 1.20A 4wcxC-4m4dA:
undetectable		 4wcxC-4m4dA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		4 / 4 LEU A 381
LEU A 339
GLY A 366
GLU A 365
 None
None
None
NAG  A 502 (-3.6A)
 0.90A 5hhjA-4m4dA:
undetectable		 5hhjA-4m4dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN
(Mus
musculus) 		5 / 9 LEU A 178
VAL A 168
SER A 187
LEU A 189
GLU A 186
 None
 1.41A 6fdyU-4m4dA:
2.4		 6fdyU-4m4dA:
20.97