SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		4 / 8 LEU A 503
VAL A 457
THR A 498
VAL A 476
 None
 0.87A 1dz9A-4m4rA:
undetectable		 1dz9A-4m4rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		4 / 8 LEU A 503
VAL A 457
THR A 498
VAL A 476
 None
 0.83A 1o76B-4m4rA:
undetectable		 1o76B-4m4rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		3 / 3 THR A 534
THR A 453
PRO A 536
 None
 0.86A 1qfiB-4m4rA:
undetectable		 1qfiB-4m4rA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		3 / 3 ALA A 445
VAL A 447
TRP A 461
 None
 0.90A 1tkqA-4m4rA:
undetectable		 1tkqA-4m4rA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		5 / 12 PRO A 379
VAL A 384
TYR A 386
TYR A 409
LEU A 403
 None
 1.30A 1z9hA-4m4rA:
undetectable		 1z9hA-4m4rA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		5 / 12 PRO A 379
VAL A 384
TYR A 386
TYR A 409
LEU A 403
 None
 1.31A 1z9hB-4m4rA:
undetectable		 1z9hB-4m4rA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		5 / 12 PRO A 379
VAL A 384
TYR A 386
TYR A 409
LEU A 403
 None
 1.30A 1z9hC-4m4rA:
undetectable		 1z9hC-4m4rA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		3 / 3 THR A 453
PRO A 536
THR A 534
 None
 0.80A 209dC-4m4rA:
undetectable		 209dC-4m4rA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		4 / 7 LEU A 503
VAL A 457
THR A 498
VAL A 476
 None
 1.04A 3fwgB-4m4rA:
undetectable		 3fwgB-4m4rA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		5 / 10 ASN A  82
VAL A  72
TYR A  70
GLY A  53
TRP A  45
 None
 1.45A 3lp1A-4m4rA:
undetectable		 3lp1A-4m4rA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4m4r EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens) 		3 / 3 SER A 224
ASP A 172
ASP A 146
 None
 0.80A 4mwzA-4m4rA:
undetectable		 4mwzA-4m4rA:
19.76