SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_A_CHDA200_0 (ILEAL BILE ACID-BINDING PROTEIN)	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	4 / 5	PRO J 198 THR J 247 VAL J 248 GLY J 246	None	1.08A	3elzA-4m4wJ: undetectable	3elzA-4m4wJ: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_B_TOPB200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	5 / 12	MET J 120 LEU J 204 LEU J 217 VAL J 220 ILE J 245	None	1.11A	3fl9B-4m4wJ: undetectable	3fl9B-4m4wJ: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_E_TOPE200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	5 / 10	MET J 120 LEU J 204 LEU J 217 VAL J 220 ILE J 245	None	1.00A	3fl9E-4m4wJ: undetectable	3fl9E-4m4wJ: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW5_A_TOPA208_1 (DIHYDROFOLATE REDUCTASE)	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	5 / 11	MET J 120 LEU J 204 LEU J 217 VAL J 220 ILE J 245	None	1.12A	3jw5A-4m4wJ: undetectable	3jw5A-4m4wJ: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW5_B_TOPB208_1 (DIHYDROFOLATE REDUCTASE)	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	5 / 10	MET J 120 LEU J 204 LEU J 217 VAL J 220 ILE J 245	None	1.14A	3jw5B-4m4wJ: undetectable	3jw5B-4m4wJ: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACA_B_DXCB1473_0 (TRANSLATION ELONGATION FACTOR SELB)	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	5 / 9	ILE J 231 GLY J 232 PHE J 274 VAL J 248 GLY J 246	None	1.40A	4acaB-4m4wJ: undetectable 4acaC-4m4wJ: undetectable	4acaB-4m4wJ: 21.34 4acaC-4m4wJ: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_A_SVRA205_1 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	4 / 7	ASN J 156 LYS J 160 TYR J 165 LEU J 164	None	1.21A	4yv5A-4m4wJ: undetectable	4yv5A-4m4wJ: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_B_SVRB207_2 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	4m4w	PRIMOSOMAL PROTEIN DNAI (Bacillus subtilis)	4 / 7	ASN J 156 LYS J 160 TYR J 165 LEU J 164	None	1.09A	4yv5B-4m4wJ: undetectable	4yv5B-4m4wJ: 17.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3ELZ_A_CHDA200_0","ILEAL BILE ACID-BINDING PROTEIN","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",4,"PRO J 198;THR J 247;VAL J 248;GLY J 246","None","1.08A","3elzA-4m4wJ:undetectable","3elzA-4m4wJ:18.36"],["3FL9_B_TOPB200_1","DIHYDROFOLATE REDUCTASE (DHFR)","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",5,"MET J 120;LEU J 204;LEU J 217;VAL J 220;ILE J 245","None","1.11A","3fl9B-4m4wJ:undetectable","3fl9B-4m4wJ:20.07"],["3FL9_E_TOPE200_1","DIHYDROFOLATE REDUCTASE (DHFR)","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",5,"MET J 120;LEU J 204;LEU J 217;VAL J 220;ILE J 245","None","1.00A","3fl9E-4m4wJ:undetectable","3fl9E-4m4wJ:20.07"],["3JW5_A_TOPA208_1","DIHYDROFOLATE REDUCTASE","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",5,"MET J 120;LEU J 204;LEU J 217;VAL J 220;ILE J 245","None","1.12A","3jw5A-4m4wJ:undetectable","3jw5A-4m4wJ:19.65"],["3JW5_B_TOPB208_1","DIHYDROFOLATE REDUCTASE","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",5,"MET J 120;LEU J 204;LEU J 217;VAL J 220;ILE J 245","None","1.14A","3jw5B-4m4wJ:undetectable","3jw5B-4m4wJ:19.65"],["4ACA_B_DXCB1473_0","TRANSLATION ELONGATION FACTOR SELB","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",5,"ILE J 231;GLY J 232;PHE J 274;VAL J 248;GLY J 246","None","1.40A","4acaB-4m4wJ:undetectable;4acaC-4m4wJ:undetectable","4acaB-4m4wJ:21.34;4acaC-4m4wJ:21.34"],["4YV5_A_SVRA205_1","BASIC PHOSPHOLIPASE A2 HOMOLOG 2","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",4,"ASN J 156;LYS J 160;TYR J 165;LEU J 164","None","1.21A","4yv5A-4m4wJ:undetectable","4yv5A-4m4wJ:17.53"],["4YV5_B_SVRB207_2","BASIC PHOSPHOLIPASE A2 HOMOLOG 2","4m4w","PRIMOSOMAL PROTEIN DNAI","Bacillus subtilis",4,"ASN J 156;LYS J 160;TYR J 165;LEU J 164","None","1.09A","4yv5B-4m4wJ:undetectable","4yv5B-4m4wJ:17.53"]]