SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 11 ILE A  53
LEU A  74
GLY A  46
PHE A  49
ALA A 114
 HEZ  A 322 ( 4.9A)
None
HEZ  A 312 ( 3.8A)
HEZ  A 312 (-3.6A)
None
 1.39A 1ju6A-4m5bA:
undetectable		 1ju6A-4m5bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 10 ILE A  53
LEU A  74
GLY A  46
PHE A  49
ALA A 114
 HEZ  A 322 ( 4.9A)
None
HEZ  A 312 ( 3.8A)
HEZ  A 312 (-3.6A)
None
 1.39A 1ju6C-4m5bA:
undetectable		 1ju6C-4m5bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 11 ALA A  68
GLY A 203
GLU A 198
ILE A  53
VAL A 206
 None
HEZ  A 306 ( 4.0A)
None
HEZ  A 322 ( 4.9A)
None
 1.15A 1pg2A-4m5bA:
undetectable		 1pg2A-4m5bA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		4 / 7 GLY A 101
GLN A  94
MET A  54
ILE A   3
 None
 1.03A 1rxcD-4m5bA:
undetectable		 1rxcD-4m5bA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		3 / 3 THR A  88
SER A 110
PHE A 119
 HEZ  A 309 ( 4.2A)
None
None
 0.87A 3d4sA-4m5bA:
undetectable		 3d4sA-4m5bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		4 / 6 GLY A 146
MET A 187
ILE A 116
VAL A 120
 None
HEZ  A 302 ( 4.9A)
HEZ  A 313 (-4.7A)
HEZ  A 313 ( 4.2A)
 1.17A 3kvvA-4m5bA:
undetectable		 3kvvA-4m5bA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 10 THR A  77
LEU A  87
LEU A  74
GLY A  70
THR A 202
 HEZ  A 312 (-4.0A)
None
None
None
None
 1.32A 3lxiA-4m5bA:
undetectable		 3lxiA-4m5bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 11 ALA A 155
ALA A  66
PRO A   4
TYR A   7
LEU A 158
 None
None
None
HEZ  A 311 (-3.6A)
None
 1.03A 3sm2B-4m5bA:
undetectable		 3sm2B-4m5bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 9 THR A  77
LEU A  87
LEU A  74
GLY A  70
THR A 202
 HEZ  A 312 (-4.0A)
None
None
None
None
 1.34A 4c9kA-4m5bA:
undetectable		 4c9kA-4m5bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 9 THR A  77
LEU A  87
LEU A  74
GLY A  70
THR A 202
 HEZ  A 312 (-4.0A)
None
None
None
None
 1.34A 4c9kB-4m5bA:
undetectable		 4c9kB-4m5bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 9 TRP A  81
GLY A 123
GLY A 121
PHE A 115
ILE A 116
 None
HEZ  A 313 ( 4.1A)
None
HEZ  A 313 ( 4.4A)
HEZ  A 313 (-4.7A)
 1.46A 4fgjA-4m5bA:
undetectable
4fgjB-4m5bA:
undetectable		 4fgjA-4m5bA:
24.18
4fgjB-4m5bA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A   3
ALA A 105
GLY A 102
ASN A 109
GLU A 157
 None
None
None
None
HEZ  A 301 (-4.8A)
 1.17A 4jlgA-4m5bA:
undetectable		 4jlgA-4m5bA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		4 / 5 ILE A  69
PHE A  92
HIS A 190
ASP A 100
 None
 1.19A 4rzvB-4m5bA:
undetectable		 4rzvB-4m5bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		4 / 6 PHE A 111
SER A  84
ALA A 114
LEU A  24
 None
None
None
HEZ  A 309 ( 4.2A)
 1.10A 5dzkg-4m5bA:
undetectable
5dzku-4m5bA:
undetectable		 5dzkg-4m5bA:
22.22
5dzku-4m5bA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM
(Caldanaerobacter
subterraneus) 		5 / 10 PHE A 188
ILE A  60
GLY A 195
TYR A 144
ASN A 148
 None
None
None
HEZ  A 305 (-3.7A)
None
 1.37A 5lbtA-4m5bA:
undetectable
5lbtB-4m5bA:
undetectable		 5lbtA-4m5bA:
23.40
5lbtB-4m5bA:
23.40