SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		5 / 12 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
None
X48  A 306 ( 4.9A)
None
None
 0.97A 1uduB-4m5oA:
undetectable		 1uduB-4m5oA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		5 / 12 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
None
X48  A 306 ( 4.9A)
None
None
 1.00A 1xozA-4m5oA:
undetectable		 1xozA-4m5oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 8 TRP A 188
SER A 194
ARG A 125
GLU A  26
 None
EDO  A 305 (-4.0A)
None
X48  A 308 (-3.5A)
 1.02A 1xr2B-4m5oA:
undetectable		 1xr2B-4m5oA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		3 / 3 TYR A 130
GLU A 195
THR A  40
 None
 0.84A 2y7hB-4m5oA:
undetectable		 2y7hB-4m5oA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		5 / 12 TYR A 110
ILE A 138
PHE A 105
THR A 143
ILE A 145
 None
 1.31A 3ndiA-4m5oA:
undetectable		 3ndiA-4m5oA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 5 PHE A 148
ILE A 171
GLY A 121
HIS A 146
 None
None
X48  A 306 ( 4.7A)
None
 1.38A 3r0lD-4m5oA:
undetectable		 3r0lD-4m5oA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 8 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
None
SO4  A 304 (-3.7A)
X48  A 306 ( 3.7A)
 1.10A 3t3sE-4m5oA:
undetectable		 3t3sE-4m5oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 8 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
None
SO4  A 304 (-3.7A)
X48  A 306 ( 3.7A)
 0.83A 3t3sF-4m5oA:
undetectable		 3t3sF-4m5oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		5 / 12 ILE A 118
ALA A 156
ILE A 171
ARG A 170
ILE A 120
 None
None
None
None
MN  A 301 ( 4.9A)
 1.03A 5e8qA-4m5oA:
undetectable		 5e8qA-4m5oA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 6 HIS A 146
LEU A 163
CYH A  45
LEU A 109
 None
 1.20A 5hrqD-4m5oA:
undetectable
5hrqG-4m5oA:
undetectable
5hrqH-4m5oA:
undetectable		 5hrqD-4m5oA:
11.76
5hrqG-4m5oA:
9.62
5hrqH-4m5oA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 6 HIS A 146
LEU A 163
CYH A  45
LEU A 109
 None
 1.17A 5hrqB-4m5oA:
undetectable
5hrqI-4m5oA:
undetectable
5hrqJ-4m5oA:
undetectable		 5hrqB-4m5oA:
11.76
5hrqI-4m5oA:
9.62
5hrqJ-4m5oA:
11.76