SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		3 / 3 GLU A 148
ALA A 143
SER A 140
 None
 0.55A 1errB-4m5pA:
undetectable		 1errB-4m5pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 10 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.46A 1fk9A-4m5pA:
undetectable		 1fk9A-4m5pA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		6 / 9 THR A  35
HIS A 188
HIS A 191
TYR A 193
GLN A 248
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 (-3.7A)
MLA  A 507 (-3.7A)
23W  A 508 ( 4.0A)
None
FMN  A 501 (-4.0A)
 0.82A 1h60A-4m5pA:
47.2		 1h60A-4m5pA:
37.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 PRO A 131
ALA A 147
SER A 133
ALA A 136
 None
 1.05A 1k5qA-4m5pA:
undetectable
1k5qB-4m5pA:
undetectable		 1k5qA-4m5pA:
18.93
1k5qB-4m5pA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 10 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.37A 1lw0A-4m5pA:
undetectable		 1lw0A-4m5pA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 11 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.34A 1lwcA-4m5pA:
undetectable		 1lwcA-4m5pA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		6 / 9 THR A  35
HIS A 188
HIS A 191
TYR A 193
GLN A 248
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 (-3.7A)
MLA  A 507 (-3.7A)
23W  A 508 ( 4.0A)
None
FMN  A 501 (-4.0A)
 0.86A 2abaA-4m5pA:
47.2		 2abaA-4m5pA:
37.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 12 LEU A 199
LEU A 222
ILE A 221
ILE A 239
PHE A 263
 None
 1.00A 2bdmA-4m5pA:
undetectable		 2bdmA-4m5pA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 VAL A 101
LEU A  63
PHE A 182
THR A  66
 None
 1.05A 2f78A-4m5pA:
undetectable		 2f78A-4m5pA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 VAL A 101
LEU A  63
PHE A 182
THR A  66
 None
 1.04A 2f78B-4m5pA:
undetectable		 2f78B-4m5pA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 12 THR A  66
ILE A 185
LEU A 112
ILE A  85
ALA A 173
 None
 1.09A 3a50A-4m5pA:
undetectable		 3a50A-4m5pA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 12 ILE A 280
VAL A 308
LEU A 199
PRO A 243
LEU A 222
 None
 1.16A 3em0B-4m5pA:
undetectable		 3em0B-4m5pA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		3 / 3 PRO A 131
LEU A 129
GLN A  74
 None
 0.70A 3hznG-4m5pA:
undetectable
3hznH-4m5pA:
undetectable		 3hznG-4m5pA:
21.67
3hznH-4m5pA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 9 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.46A 3lp0A-4m5pA:
undetectable		 3lp0A-4m5pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 10 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.46A 3lp1A-4m5pA:
undetectable		 3lp1A-4m5pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 12 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.30A 3mecA-4m5pA:
undetectable		 3mecA-4m5pA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 12 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.36A 3medA-4m5pA:
undetectable
3medB-4m5pA:
undetectable		 3medA-4m5pA:
21.45
3medB-4m5pA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 5 ILE A 336
ARG A 289
THR A 331
GLU A 306
 None
 1.17A 3ny4A-4m5pA:
undetectable		 3ny4A-4m5pA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 10 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.41A 3qipA-4m5pA:
undetectable		 3qipA-4m5pA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 ILE A 280
ILE A 283
VAL A 267
LEU A 270
 None
 0.68A 3r9vA-4m5pA:
undetectable
3r9vB-4m5pA:
undetectable		 3r9vA-4m5pA:
22.75
3r9vB-4m5pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 11 SER A 284
ILE A 283
VAL A 308
PHE A 263
VAL A 267
 None
 1.26A 3rf4A-4m5pA:
undetectable
3rf4C-4m5pA:
undetectable		 3rf4A-4m5pA:
16.27
3rf4C-4m5pA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 11 SER A 284
ILE A 283
VAL A 308
PHE A 263
VAL A 267
 None
 1.28A 3rf4A-4m5pA:
undetectable
3rf4B-4m5pA:
undetectable		 3rf4A-4m5pA:
16.27
3rf4B-4m5pA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 11 SER A 284
ILE A 283
VAL A 308
PHE A 263
VAL A 267
 None
 1.26A 3rf4B-4m5pA:
undetectable
3rf4C-4m5pA:
undetectable		 3rf4B-4m5pA:
16.27
3rf4C-4m5pA:
16.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		8 / 9 THR A  35
ALA A  68
HIS A 188
HIS A 191
TYR A 193
PHE A 247
ASN A 293
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 ( 3.3A)
FMN  A 501 (-3.7A)
MLA  A 507 (-3.7A)
23W  A 508 ( 4.0A)
23W  A 508 ( 4.4A)
MLA  A 507 ( 4.1A)
FMN  A 501 (-4.0A)
 0.29A 3upwA-4m5pA:
75.4		 3upwA-4m5pA:
99.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 THR A  35
HIS A 188
TYR A 193
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 (-3.7A)
23W  A 508 ( 4.0A)
FMN  A 501 (-4.0A)
 0.24A 4a3uA-4m5pA:
47.2		 4a3uA-4m5pA:
33.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 THR A  35
HIS A 188
TYR A 193
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 (-3.7A)
23W  A 508 ( 4.0A)
FMN  A 501 (-4.0A)
 0.23A 4a3uB-4m5pA:
47.5		 4a3uB-4m5pA:
33.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		3 / 3 GLN A 248
ASP A 196
GLN A 200
 None
 0.90A 4aztA-4m5pA:
undetectable		 4aztA-4m5pA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 12 SER A 309
VAL A 308
GLN A 200
ILE A 241
HIS A 258
 NA  A 505 ( 4.3A)
None
None
None
None
 1.45A 4c49D-4m5pA:
undetectable		 4c49D-4m5pA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 6 THR A  35
HIS A 188
HIS A 191
TYR A 193
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 (-3.7A)
MLA  A 507 (-3.7A)
23W  A 508 ( 4.0A)
FMN  A 501 (-4.0A)
 0.28A 4df2A-4m5pA:
75.3		 4df2A-4m5pA:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 ASP A 325
GLU A 298
ASP A 335
GLU A 334
 None
 1.18A 4feuB-4m5pA:
undetectable		 4feuB-4m5pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 ASP A 325
GLU A 298
ASP A 335
GLU A 334
 None
 1.22A 4fevD-4m5pA:
undetectable		 4fevD-4m5pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 ASP A 325
GLU A 298
ASP A 335
GLU A 334
 None
 1.21A 4fevF-4m5pA:
undetectable		 4fevF-4m5pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 ASP A 325
GLU A 298
ASP A 335
GLU A 334
 None
 1.21A 4fexB-4m5pA:
undetectable		 4fexB-4m5pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 7 ASP A 325
GLU A 298
ASP A 335
GLU A 334
 None
 1.21A 4gkhG-4m5pA:
undetectable		 4gkhG-4m5pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 8 ASP A 325
GLU A 298
ASP A 335
GLU A 334
 None
 1.21A 4gkiC-4m5pA:
undetectable		 4gkiC-4m5pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 4 LYS A  92
ALA A  93
SER A  46
THR A  44
 None
 1.43A 4i89B-4m5pA:
undetectable		 4i89B-4m5pA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 6 LEU A 222
ILE A 221
LEU A 266
TYR A 265
 None
 0.92A 4w5nA-4m5pA:
undetectable		 4w5nA-4m5pA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 11 GLY A 320
SER A 323
ALA A 326
LEU A 359
LEU A   9
 FMN  A 501 ( 3.7A)
None
None
None
None
 1.14A 4xumB-4m5pA:
undetectable		 4xumB-4m5pA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 11 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.33A 5hbmA-4m5pA:
undetectable		 5hbmA-4m5pA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 12 ALA A  14
SER A   7
ILE A   6
LEU A 365
THR A  27
 None
 1.18A 5hi6B-4m5pA:
undetectable		 5hi6B-4m5pA:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 8 THR A  35
HIS A 188
TYR A 193
PHE A 247
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 (-3.7A)
23W  A 508 ( 4.0A)
23W  A 508 ( 4.4A)
FMN  A 501 (-4.0A)
 0.36A 5v4vA-4m5pA:
58.8		 5v4vA-4m5pA:
41.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 8 THR A  35
HIS A 188
TYR A 193
PHE A 247
TYR A 374
 FMN  A 501 ( 3.8A)
FMN  A 501 (-3.7A)
23W  A 508 ( 4.0A)
23W  A 508 ( 4.4A)
FMN  A 501 (-4.0A)
 0.34A 5v4vB-4m5pA:
58.8		 5v4vB-4m5pA:
41.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 6 GLU A 223
TYR A 210
GLY A 211
GLY A 212
 None
 0.98A 5x7pB-4m5pA:
undetectable		 5x7pB-4m5pA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 10 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.40A 6bsgA-4m5pA:
undetectable		 6bsgA-4m5pA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 10 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.43A 6bsiA-4m5pA:
undetectable		 6bsiA-4m5pA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		5 / 10 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.38A 6bsjA-4m5pA:
undetectable		 6bsjA-4m5pA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		4 / 8 LEU A 112
VAL A 232
LEU A 228
ILE A 231
 None
 0.90A 6cb4A-4m5pA:
undetectable		 6cb4A-4m5pA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		3 / 3 ASN A 152
PRO A 131
GLN A  74
 None
 0.83A 6jnhA-4m5pA:
undetectable		 6jnhA-4m5pA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4m5p NADPH DEHYDROGENASE
(Scheffersomyces
stipitis) 		3 / 3 ASN A 152
PRO A 131
GLN A  74
 None
 0.82A 6jogA-4m5pA:
undetectable		 6jogA-4m5pA:
17.37