SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_A_SALA301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	4m5t	ALPHA-CRYSTALLIN B CHAIN (Homo sapiens)	4 / 8	VAL A 77 VAL A 93 TYR A 122 ILE A 124	None	1.00A	3remA-4m5tA: undetectable	3remA-4m5tA: 15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_B_SALB301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	4m5t	ALPHA-CRYSTALLIN B CHAIN (Homo sapiens)	4 / 8	VAL A 77 VAL A 93 TYR A 122 ILE A 124	None	0.99A	3remB-4m5tA: undetectable	3remB-4m5tA: 15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_J_CLMJ221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4m5t	ALPHA-CRYSTALLIN B CHAIN (Homo sapiens)	5 / 12	PHE A 84 LEU A 143 VAL A 100 PHE A 118 VAL A 81	None	1.26A	3u9fJ-4m5tA: undetectable 3u9fK-4m5tA: undetectable	3u9fJ-4m5tA: 19.81 3u9fK-4m5tA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GSD_A_STRA401_0 (PROGESTERONE 5-BETA-REDUCTASE)	4m5t	ALPHA-CRYSTALLIN B CHAIN (Homo sapiens)	5 / 12	VAL A 128 ILE A 124 SER A 135 VAL A 77 ILE A 98	None	1.48A	6gsdA-4m5tA: undetectable	6gsdA-4m5tA: 18.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3REM_A_SALA301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","4m5t","ALPHA-CRYSTALLIN B CHAIN","Homo sapiens",4,"VAL A  77;VAL A  93;TYR A 122;ILE A 124","None","1.00A","3remA-4m5tA:undetectable","3remA-4m5tA:15.32"],["3REM_B_SALB301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","4m5t","ALPHA-CRYSTALLIN B CHAIN","Homo sapiens",4,"VAL A  77;VAL A  93;TYR A 122;ILE A 124","None","0.99A","3remB-4m5tA:undetectable","3remB-4m5tA:15.32"],["3U9F_J_CLMJ221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","4m5t","ALPHA-CRYSTALLIN B CHAIN","Homo sapiens",5,"PHE A  84;LEU A 143;VAL A 100;PHE A 118;VAL A  81","None","1.26A","3u9fJ-4m5tA:undetectable;3u9fK-4m5tA:undetectable","3u9fJ-4m5tA:19.81;3u9fK-4m5tA:19.81"],["6GSD_A_STRA401_0","PROGESTERONE 5-BETA-REDUCTASE","4m5t","ALPHA-CRYSTALLIN B CHAIN","Homo sapiens",5,"VAL A 128;ILE A 124;SER A 135;VAL A  77;ILE A  98","None","1.48A","6gsdA-4m5tA:undetectable","6gsdA-4m5tA:18.60"]]