SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ5_A_ACTA2145_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 ARG H  97
TYR H  34
TYR H  58
TYR H 100
 None
 1.41A 1pj5A-4m5yH:
0.0		 1pj5A-4m5yH:
14.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA H  93
ARG H  94
TYR H 100
TYR H  58
 None
 1.22A 2ajvH-4m5yH:
27.8
2ajvL-4m5yH:
14.1		 2ajvH-4m5yH:
62.07
2ajvL-4m5yH:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 2y03A-4m5yH:
undetectable		 2y03A-4m5yH:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.44A 3huoA-4m5yH:
undetectable		 3huoA-4m5yH:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LYS H  60
PRO H  61
SER H  62
 None
 0.50A 4k50I-4m5yH:
undetectable		 4k50I-4m5yH:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.90A 4xumA-4m5yH:
undetectable		 4xumA-4m5yH:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 6h7mB-4m5yH:
undetectable		 6h7mB-4m5yH:
20.62