SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4m62 T117
(synthetic
construct) 		5 / 10 ILE S 151
VAL S  19
GLY S  89
VAL S 133
LEU S 144
 None
 1.05A 3elzC-4m62S:
undetectable		 3elzC-4m62S:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4m62 T117
(synthetic
construct) 		4 / 5 ILE S  32
ALA S  36
HIS S  75
MET S 114
 None
 1.22A 4ac9B-4m62S:
undetectable
4ac9C-4m62S:
undetectable		 4ac9B-4m62S:
17.49
4ac9C-4m62S:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4m62 T117
(synthetic
construct) 		4 / 5 ILE S  32
ALA S  36
HIS S  75
MET S 114
 None
 1.24A 4acaB-4m62S:
undetectable
4acaC-4m62S:
undetectable		 4acaB-4m62S:
17.49
4acaC-4m62S:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 MET S 146
ARG S 158
VAL S  19
GLU S 150
 None
 1.27A 4uh0A-4m62S:
undetectable
4uh0B-4m62S:
undetectable		 4uh0A-4m62S:
16.71
4uh0B-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 GLU S 150
MET S 146
ARG S 158
VAL S  19
 None
 1.48A 4uh0A-4m62S:
undetectable
4uh0B-4m62S:
undetectable		 4uh0A-4m62S:
16.71
4uh0B-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 GLU S 150
MET S 146
ARG S 158
VAL S  19
 None
 1.47A 5adaA-4m62S:
undetectable
5adaB-4m62S:
undetectable		 5adaA-4m62S:
16.71
5adaB-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m62 T117
(synthetic
construct) 		3 / 3 VAL S  45
SER S  87
MET S   9
 None
 0.93A 5ikqA-4m62S:
undetectable		 5ikqA-4m62S:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 MET S 146
ARG S 158
VAL S  19
GLU S 150
 None
 1.44A 5unuA-4m62S:
undetectable
5unuB-4m62S:
undetectable		 5unuA-4m62S:
16.71
5unuB-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 MET S 146
ARG S 158
VAL S  19
GLU S 150
 None
 1.40A 5unwA-4m62S:
undetectable
5unwB-4m62S:
undetectable		 5unwA-4m62S:
16.71
5unwB-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 GLU S 150
MET S 146
ARG S 158
VAL S  19
 None
 1.43A 5unyA-4m62S:
undetectable
5unyB-4m62S:
undetectable		 5unyA-4m62S:
16.71
5unyB-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 GLU S 150
MET S 146
ARG S 158
VAL S  19
 None
 1.45A 5uo0A-4m62S:
undetectable
5uo0B-4m62S:
undetectable		 5uo0A-4m62S:
16.71
5uo0B-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 MET S 146
ARG S 158
VAL S  19
GLU S 150
 None
 1.50A 5uo3A-4m62S:
undetectable
5uo3B-4m62S:
undetectable		 5uo3A-4m62S:
15.87
5uo3B-4m62S:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 GLU S 150
MET S 146
ARG S 158
VAL S  19
 None
 1.38A 5vuoA-4m62S:
undetectable
5vuoB-4m62S:
undetectable		 5vuoA-4m62S:
16.71
5vuoB-4m62S:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 GLU S 150
MET S 146
ARG S 158
VAL S  19
 None
 1.38A 6auxA-4m62S:
undetectable
6auxB-4m62S:
undetectable		 6auxA-4m62S:
17.42
6auxB-4m62S:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m62 T117
(synthetic
construct) 		4 / 7 MET S 146
ARG S 158
VAL S  19
GLU S 150
 None
 1.40A 6av1A-4m62S:
undetectable
6av1B-4m62S:
undetectable		 6av1A-4m62S:
18.71
6av1B-4m62S:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4m62 T117
(synthetic
construct) 		5 / 12 VAL S  88
VAL S  71
GLY S  63
ALA S 100
VAL S 126
 None
 0.98A 6bqgA-4m62S:
undetectable		 6bqgA-4m62S:
21.74