SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 9 ASP A  86
VAL A  88
GLY A  29
VAL A  53
ILE A  52
 CL  A 404 (-4.6A)
None
ANP  A 401 (-3.8A)
None
None
 1.06A 1hpvB-4m69A:
undetectable		 1hpvB-4m69A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
THR A  95
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.64A 1iepA-4m69A:
23.6		 1iepA-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 ALA A  49
LYS A  51
LEU A  93
THR A  95
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 0.67A 1m17A-4m69A:
14.7		 1m17A-4m69A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 ALA A  49
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
None
 0.67A 1uwhA-4m69A:
25.9		 1uwhA-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
LYS A  51
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
None
 0.74A 1uwhB-4m69A:
25.8		 1uwhB-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
None
 0.69A 1uwjA-4m69A:
7.4		 1uwjA-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
None
 0.69A 1uwjB-4m69A:
7.5		 1uwjB-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		4 / 5 PHE B 385
LEU B 450
PHE B 324
SER B 248
 None
 1.35A 1wrkB-4m69B:
undetectable		 1wrkB-4m69B:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
THR A  95
GLY A 101
LEU A 150
ASP A 161
PHE A 162
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
 0.61A 1xkkA-4m69A:
27.3		 1xkkA-4m69A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 9 VAL A  36
LYS A  51
LEU A  76
LEU A  93
MET A  98
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-2.9A)
None
None
None
None
 0.67A 1xkkA-4m69A:
27.3		 1xkkA-4m69A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		3 / 3 LEU A  25
HIS A  40
LYS A  23
 None
None
CL  A 405 ( 4.3A)
 1.02A 1y7iA-4m69A:
undetectable		 1y7iA-4m69A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		5 / 12 LEU B 453
PHE B 385
GLY B 386
CYH B 435
LEU B 428
 None
 1.21A 2bxeB-4m69B:
undetectable		 2bxeB-4m69B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		4 / 7 SER B 320
SER B 322
SER B 323
ASN B 318
 None
 1.06A 2cmlA-4m69B:
undetectable		 2cmlA-4m69B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		4 / 8 SER B 320
SER B 322
SER B 323
ASN B 318
 None
 1.11A 2cmlB-4m69B:
undetectable		 2cmlB-4m69B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		4 / 8 SER B 320
SER B 322
SER B 323
ASN B 318
 None
 1.08A 2cmlC-4m69B:
undetectable		 2cmlC-4m69B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		4 / 8 SER B 320
SER B 322
SER B 323
ASN B 318
 None
 1.10A 2cmlD-4m69B:
undetectable		 2cmlD-4m69B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 11 VAL A  28
GLY A  29
VAL A  36
ALA A  49
SER A 102
LEU A 150
ASP A 161
 ANP  A 401 (-4.7A)
ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.6A)
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.77A 2evaA-4m69A:
26.7		 2evaA-4m69A:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
THR A  95
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.65A 2hyyA-4m69A:
23.9		 2hyyA-4m69A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
THR A  95
PHE A  97
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.67A 2hyyB-4m69A:
24.1		 2hyyB-4m69A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
THR A  95
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.63A 2hyyB-4m69A:
24.1		 2hyyB-4m69A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
LYS A  51
LEU A  93
THR A  95
GLY A 101
LEU A 150
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.69A 2itoA-4m69A:
24.0		 2itoA-4m69A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		8 / 12 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  93
THR A  95
GLY A 101
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.68A 2ityA-4m69A:
24.2		 2ityA-4m69A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 GLY A  29
VAL A  36
ALA A  49
LEU A  74
MET A  98
GLY A 101
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
None
None
 0.71A 2wgjA-4m69A:
25.2		 2wgjA-4m69A:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		10 / 12 VAL A  36
ALA A  49
MET A  65
LEU A  76
THR A  95
GLY A 101
LEU A 150
ASP A 161
PHE A 162
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
None
 0.75A 3bbtB-4m69A:
27.3		 3bbtB-4m69A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		11 / 12 VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
THR A  95
GLY A 101
LEU A 150
ASP A 161
PHE A 162
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
None
 0.66A 3bbtD-4m69A:
19.1		 3bbtD-4m69A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 ALA A  49
THR A  95
PHE A  97
HIS A 141
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
None
 0.68A 3cs9C-4m69A:
23.9		 3cs9C-4m69A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
THR A  95
PHE A  97
GLY A 101
HIS A 141
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
None
None
 0.85A 3cs9D-4m69A:
23.1		 3cs9D-4m69A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 LEU A  93
PHE A 162
ALA A  64
VAL A  73
ILE A  58
 None
 1.10A 3czhB-4m69A:
undetectable		 3czhB-4m69A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		5 / 12 ILE B 362
GLU B 418
ARG B 295
LEU B 284
ARG B 281
 None
 1.16A 3ix9B-4m69B:
undetectable		 3ix9B-4m69B:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
THR A  95
PHE A  97
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.76A 3k5vA-4m69A:
23.0		 3k5vA-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
THR A  95
PHE A  97
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.68A 3k5vB-4m69A:
17.5		 3k5vB-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
THR A  95
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.65A 3k5vB-4m69A:
17.5		 3k5vB-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 8 ALA A  49
LYS A  51
LEU A  93
THR A  95
MET A  98
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 0.42A 3lfaA-4m69A:
19.4		 3lfaA-4m69A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 8 VAL A  28
ALA A  49
LEU A  93
THR A  95
MET A  98
 ANP  A 401 (-4.7A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
 0.56A 3lfaA-4m69A:
19.4		 3lfaA-4m69A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 9 ALA A  49
LYS A  51
PHE A  97
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 1.03A 3miyB-4m69A:
25.3		 3miyB-4m69A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
THR A  95
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.64A 3ms9B-4m69A:
23.6		 3ms9B-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
THR A  95
PHE A  97
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.69A 3mssB-4m69A:
23.9		 3mssB-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
THR A  95
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.62A 3mssB-4m69A:
23.9		 3mssB-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
THR A  95
PHE A  97
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.69A 3mssD-4m69A:
18.6		 3mssD-4m69A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 0.73A 3og7A-4m69A:
27.2		 3og7A-4m69A:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  28
GLY A  29
VAL A  36
ALA A  49
LEU A  76
THR A  95
 ANP  A 401 (-4.7A)
ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
 1.01A 3ohtA-4m69A:
5.5		 3ohtA-4m69A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  28
GLY A  29
VAL A  36
ALA A  49
THR A  95
LEU A 150
 ANP  A 401 (-4.7A)
ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-4.8A)
 0.89A 3ohtA-4m69A:
5.5		 3ohtA-4m69A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 11 ASP A  86
VAL A  88
GLY A  29
VAL A  53
ILE A  52
 CL  A 404 (-4.6A)
None
ANP  A 401 (-3.8A)
None
None
 1.09A 3oxvD-4m69A:
undetectable		 3oxvD-4m69A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PQZ_L_CCSL11_0
(GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 7
CYCLIC PEPTIDE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 4 LEU B 375
TRP A 217
PHE B 373
PRO B 372
 None
 1.44A 3pqzD-4m69B:
0.0
3pqzL-4m69B:
undetectable		 3pqzD-4m69B:
16.96
3pqzL-4m69B:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PQZ_M_CCSM11_0
(GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 7
CYCLIC PEPTIDE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus;
Mus
musculus) 		4 / 4 LEU B 375
TRP A 217
PHE B 373
PRO B 372
 None
 1.44A 3pqzC-4m69B:
0.0
3pqzM-4m69B:
undetectable		 3pqzC-4m69B:
16.96
3pqzM-4m69B:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		3 / 3 LEU A 132
HIS A 133
MET A 129
 None
 0.91A 3thrD-4m69A:
undetectable		 3thrD-4m69A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  93
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
None
ANP  A 401 (-4.8A)
 0.66A 3ug2A-4m69A:
23.6		 3ug2A-4m69A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 ALA A  49
LYS A  51
THR A  95
LEU A 132
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.79A 3zosA-4m69A:
22.0		 3zosA-4m69A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 ALA A  49
LYS A  51
THR A  95
LEU A 132
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.80A 3zosB-4m69A:
22.1		 3zosB-4m69A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 LYS A  51
ASP A 143
LYS A 145
ASN A 148
ASP A 161
GLY A 163
 ANP  A 401 (-2.9A)
ANP  A 401 (-2.6A)
ANP  A 401 (-3.0A)
MG  A 403 ( 2.6A)
MG  A 403 ( 3.1A)
None
 0.72A 4an2A-4m69A:
25.9		 4an2A-4m69A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 LYS A  51
LEU A  76
ASP A 143
LYS A 145
ASN A 148
ASP A 161
 ANP  A 401 (-2.9A)
None
ANP  A 401 (-2.6A)
ANP  A 401 (-3.0A)
MG  A 403 ( 2.6A)
MG  A 403 ( 3.1A)
 1.04A 4an2A-4m69A:
25.9		 4an2A-4m69A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 ALA A  49
LYS A  51
LEU A  74
THR A  95
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.84A 4c8bA-4m69A:
29.2		 4c8bA-4m69A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 ALA A  49
LYS A  51
LEU A  74
THR A  95
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.93A 4c8bB-4m69A:
29.0		 4c8bB-4m69A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 10 ASP A  86
VAL A  88
GLY A  29
VAL A  53
ILE A  52
 CL  A 404 (-4.6A)
None
ANP  A 401 (-3.8A)
None
None
 1.12A 4dqcA-4m69A:
undetectable		 4dqcA-4m69A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		8 / 12 VAL A  36
ALA A  49
LYS A  51
THR A  95
MET A  98
GLY A 101
LEU A 150
ASP A 161
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.60A 4hjoA-4m69A:
26.0		 4hjoA-4m69A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  76
LEU A  93
LEU A 164
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
None
 0.61A 4ifgA-4m69A:
19.0		 4ifgA-4m69A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 9 ASP A  86
VAL A  88
GLY A  29
VAL A  53
ILE A  52
 CL  A 404 (-4.6A)
None
ANP  A 401 (-3.8A)
None
None
 1.10A 4ll3B-4m69A:
undetectable		 4ll3B-4m69A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 LYS A  51
ASN A 148
ASP A 161
PHE A 162
GLY A 163
 ANP  A 401 (-2.9A)
MG  A 403 ( 2.6A)
MG  A 403 ( 3.1A)
None
None
 0.48A 4lmnA-4m69A:
25.5		 4lmnA-4m69A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
LYS A  51
THR A  95
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 0.75A 4mxxB-4m69A:
23.0		 4mxxB-4m69A:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 6 VAL A  36
ALA A  49
LYS A  51
LEU A  74
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-4.8A)
 0.61A 4o0uA-4m69A:
7.1		 4o0uA-4m69A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		5 / 12 LEU B 453
PHE B 385
GLY B 386
CYH B 435
LEU B 428
 None
 1.33A 4ot2A-4m69B:
undetectable		 4ot2A-4m69B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
LYS A  51
THR A  95
GLY A 101
LEU A 150
ALA A 160
ASP A 161
 ANP  A 401 (-4.5A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
MG  A 403 ( 3.1A)
 0.64A 4otwA-4m69A:
26.9		 4otwA-4m69A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		3 / 3 THR B 361
ASN B 371
PHE B 373
 None
 0.81A 4pd9A-4m69B:
undetectable		 4pd9A-4m69B:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
LYS A  51
LEU A  74
THR A  95
SER A 102
PHE A 162
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
ANP  A 401 (-3.6A)
None
 0.95A 4rzvA-4m69A:
7.8		 4rzvA-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LEU A  74
THR A  95
SER A 102
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
ANP  A 401 (-3.6A)
None
 0.91A 4rzvB-4m69A:
28.0		 4rzvB-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 0.90A 4rzvB-4m69A:
28.0		 4rzvB-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 11 ALA A  49
LYS A  51
THR A  95
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 0.95A 4wa9A-4m69A:
23.1		 4wa9A-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 11 ALA A  49
THR A  95
MET A  98
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.79A 4wa9A-4m69A:
23.1		 4wa9A-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 ALA A  49
THR A  95
PHE A  97
MET A  98
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.85A 4wa9B-4m69A:
24.4		 4wa9B-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
THR A  95
MET A  98
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.78A 4wa9B-4m69A:
24.4		 4wa9B-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
LYS A  51
PHE A  97
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.76A 4xeyA-4m69A:
25.0		 4xeyA-4m69A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
LYS A  51
THR A  95
PHE A  97
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.77A 4xeyA-4m69A:
25.0		 4xeyA-4m69A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 1.04A 4xv2A-4m69A:
27.1		 4xv2A-4m69A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		5 / 12 LEU B 453
PHE B 385
GLY B 386
CYH B 435
LEU B 428
 None
 1.35A 4zbrA-4m69B:
undetectable		 4zbrA-4m69B:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 1.12A 5cswA-4m69A:
26.9		 5cswA-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 1.11A 5cswB-4m69A:
26.9		 5cswB-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LEU A  74
THR A  95
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.56A 5h2uA-4m69A:
21.9		 5h2uA-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
LEU A  74
THR A  95
GLY A 101
LEU A 150
ASP A 161
 ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.49A 5h2uC-4m69A:
22.6		 5h2uC-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 ALA A  49
LYS A  51
LEU A  74
THR A  95
ASP A 161
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
MG  A 403 ( 3.1A)
 0.56A 5h2uC-4m69A:
22.6		 5h2uC-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LEU A  74
THR A  95
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.55A 5h2uD-4m69A:
22.3		 5h2uD-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
LEU A  74
THR A  95
GLY A 101
LEU A 150
ASP A 161
 ANP  A 401 (-4.5A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.58A 5h2uD-4m69A:
22.3		 5h2uD-4m69A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 ALA A  49
LYS A  51
LEU A  74
THR A  95
LEU A 132
HIS A 141
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
None
 0.79A 5hi2A-4m69A:
25.9		 5hi2A-4m69A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 GLY A  31
VAL A  36
ALA A  49
LYS A  51
THR A  95
 ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
 0.57A 5hieA-4m69A:
26.6		 5hieA-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
 0.75A 5hieA-4m69A:
26.6		 5hieA-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 GLY A  31
VAL A  36
ALA A  49
LYS A  51
THR A  95
 ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
 0.58A 5hieB-4m69A:
26.5		 5hieB-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
 0.76A 5hieB-4m69A:
26.5		 5hieB-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 GLY A  29
GLY A  31
VAL A  36
ALA A  49
LYS A  51
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-4.8A)
 1.28A 5hieC-4m69A:
26.8		 5hieC-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 GLY A  29
GLY A  31
VAL A  36
ALA A  49
LYS A  51
THR A  95
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
 0.66A 5hieC-4m69A:
26.8		 5hieC-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
 0.72A 5hieC-4m69A:
26.8		 5hieC-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 GLY A  31
VAL A  36
ALA A  49
LYS A  51
VAL A  62
THR A  95
 ANP  A 401 (-3.4A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
 1.32A 5hieD-4m69A:
26.7		 5hieD-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
 0.76A 5hieD-4m69A:
26.7		 5hieD-4m69A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 11 LEU A 107
ALA A 104
GLU A 224
LEU A 215
LEU A 150
 None
None
None
None
ANP  A 401 (-4.8A)
 1.29A 5hyrB-4m69A:
undetectable		 5hyrB-4m69A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		3 / 3 VAL A 209
GLN A 282
CYH A 284
 None
 0.82A 5icxC-4m69A:
undetectable
5icxF-4m69A:
undetectable		 5icxC-4m69A:
20.00
5icxF-4m69A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 ILE A 214
GLY A 213
ALA A 221
SER A 102
ILE A 149
 None
None
None
ANP  A 401 (-3.6A)
None
 1.09A 5igvA-4m69A:
5.3		 5igvA-4m69A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
LYS A  51
MET A  65
THR A  95
LEU A 150
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
ANP  A 401 (-4.8A)
None
 0.80A 5p9iA-4m69A:
26.6		 5p9iA-4m69A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
MET A  65
THR A  95
GLY A 101
LEU A 150
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.87A 5p9iA-4m69A:
26.6		 5p9iA-4m69A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		4 / 7 GLU B 381
ALA B 303
GLY B 305
TYR B 307
 None
 0.84A 5uxdA-4m69B:
4.4		 5uxdA-4m69B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  93
LEU A 150
ASP A 161
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.64A 5yu9A-4m69A:
26.5		 5yu9A-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 GLY A  29
VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
ANP  A 401 (-4.8A)
 0.96A 5yu9A-4m69A:
26.5		 5yu9A-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  93
LEU A 150
ASP A 161
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.76A 5yu9B-4m69A:
26.5		 5yu9B-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 GLY A  29
VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
ANP  A 401 (-4.8A)
 1.00A 5yu9B-4m69A:
26.5		 5yu9B-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A  93
GLY A 101
ASP A 161
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
MG  A 403 ( 3.1A)
 0.83A 5yu9C-4m69A:
26.4		 5yu9C-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
GLY A 101
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
None
 1.13A 5yu9C-4m69A:
26.4		 5yu9C-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
GLY A 101
LEU A 150
ASP A 161
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
 0.78A 5yu9D-4m69A:
26.8		 5yu9D-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
LEU A 150
ASP A 161
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
 0.71A 5yu9D-4m69A:
26.8		 5yu9D-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A 150
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-4.8A)
None
 1.02A 5yu9D-4m69A:
26.8		 5yu9D-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		6 / 12 VAL A  36
ALA A  49
MET A  65
GLY A 101
LEU A 150
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
None
ANP  A 401 (-4.8A)
None
 1.04A 5yu9D-4m69A:
26.8		 5yu9D-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		4 / 6 SER A 275
ALA A 203
ALA A 206
SER A 204
 None
 1.04A 6bocA-4m69A:
undetectable
6bocB-4m69A:
undetectable
6bocC-4m69A:
undetectable
6bocD-4m69A:
undetectable		 6bocA-4m69A:
6.74
6bocB-4m69A:
6.74
6bocC-4m69A:
6.74
6bocD-4m69A:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		7 / 12 VAL A  36
ALA A  49
LYS A  51
THR A  95
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 0.77A 6fnmA-4m69A:
23.7		 6fnmA-4m69A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 12 GLY A 186
GLY A 185
LEU A 227
GLY A 222
PRO A 251
 SEP  A 184 ( 3.2A)
SEP  A 184 ( 2.4A)
None
None
None
 1.05A 6gngB-4m69A:
undetectable		 6gngB-4m69A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
(Mus
musculus) 		5 / 11 ASP A 143
LEU A 132
GLY A 163
SER A 165
ALA A 203
 ANP  A 401 (-2.6A)
None
None
None
None
 1.25A 6ieyA-4m69A:
undetectable
6ieyB-4m69A:
undetectable		 6ieyA-4m69A:
23.63
6ieyB-4m69A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
(Mus
musculus) 		5 / 12 PHE B 337
GLY B 336
SER B 323
LEU B 306
ILE B 251
 None
 1.34A 6md4A-4m69B:
undetectable		 6md4A-4m69B:
15.38