SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 THR A 203
GLU A  22
HIS A  52
 None
 0.84A 1xwfA-4m6rA:
undetectable		 1xwfA-4m6rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 THR A 203
GLU A  22
HIS A  52
 None
 0.84A 1xwfB-4m6rA:
undetectable		 1xwfB-4m6rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 THR A 203
GLU A  22
HIS A  52
 None
 0.82A 1xwfC-4m6rA:
undetectable		 1xwfC-4m6rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 THR A 203
GLU A  22
HIS A  52
 None
 0.85A 1xwfD-4m6rA:
undetectable		 1xwfD-4m6rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		4 / 6 GLN A  96
HIS A 195
HIS A 117
HIS A 115
 None
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 1.23A 3nvcA-4m6rA:
undetectable		 3nvcA-4m6rA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		5 / 12 ILE A 135
LEU A 159
ALA A 121
THR A 125
VAL A 161
 None
 1.05A 3rukA-4m6rA:
undetectable		 3rukA-4m6rA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		5 / 12 ILE A 135
LEU A 159
ALA A 121
THR A 125
VAL A 161
 None
 1.08A 3rukB-4m6rA:
undetectable		 3rukB-4m6rA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		5 / 9 GLY A  46
GLY A  47
PHE A 101
GLY A  45
TYR A 198
 ZN  A 301 ( 4.9A)
None
None
None
None
 1.31A 3ztvA-4m6rA:
undetectable		 3ztvA-4m6rA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 ASP A 157
ARG A 154
ASP A 186
 None
 0.66A 4fp9A-4m6rA:
undetectable		 4fp9A-4m6rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 ASP A 157
ARG A 154
ASP A 186
 None
 0.67A 4fp9C-4m6rA:
undetectable		 4fp9C-4m6rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 ASP A 157
ARG A 154
ASP A 186
 None
 0.70A 4fp9F-4m6rA:
undetectable		 4fp9F-4m6rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		3 / 3 PRO A 162
VAL A 197
HIS A 115
 None
None
ZN  A 301 (-3.3A)
 0.84A 4pevC-4m6rA:
undetectable		 4pevC-4m6rA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		5 / 11 ASN A 166
HIS A 195
HIS A 117
VAL A 192
LEU A 100
 None
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
None
None
 1.23A 4yhaD-4m6rA:
undetectable		 4yhaD-4m6rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		5 / 10 ASN A 166
HIS A 195
HIS A 117
VAL A 192
LEU A 100
 None
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
None
None
 1.40A 4yhaF-4m6rA:
undetectable		 4yhaF-4m6rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		4 / 4 GLU A  30
PRO A  29
ILE A  28
LEU A  27
 None
 1.12A 5m45A-4m6rA:
undetectable		 5m45A-4m6rA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		4 / 4 GLU A  30
PRO A  29
ILE A  28
LEU A  27
 None
 1.18A 5m45D-4m6rA:
undetectable		 5m45D-4m6rA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		4 / 4 GLU A  30
PRO A  29
ILE A  28
LEU A  27
 None
 1.13A 5m45G-4m6rA:
undetectable		 5m45G-4m6rA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		4 / 4 GLU A  30
PRO A  29
ILE A  28
LEU A  27
 None
 1.21A 5m45J-4m6rA:
undetectable		 5m45J-4m6rA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE
(Homo
sapiens) 		5 / 9 VAL A 197
HIS A 117
GLY A 196
ILE A 220
LEU A 217
 None
ZN  A 301 (-3.3A)
None
None
None
 1.35A 6c2mC-4m6rA:
undetectable		 6c2mC-4m6rA:
13.16