SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 5 LEU A 108
LEU A  95
LEU A 103
MET A  45
None
0.99A 2oaxF-4m6tA:
undetectable
2oaxF-4m6tA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 6 MET A  53
MET A  80
MET A  85
LEU A 103
None
1.15A 2oz7A-4m6tA:
undetectable
2oz7A-4m6tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 5 LEU A 108
PRO A 109
LEU A 112
ILE A 150
None
0.77A 2qd4A-4m6tA:
undetectable
2qd4A-4m6tA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 7 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
1.03A 2v2gA-4m6tA:
undetectable
2v2gB-4m6tA:
undetectable
2v2gA-4m6tA:
24.18
2v2gB-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 7 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
1.02A 2v2gA-4m6tA:
undetectable
2v2gB-4m6tA:
undetectable
2v2gA-4m6tA:
24.18
2v2gB-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 7 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
1.03A 2v2gC-4m6tA:
undetectable
2v2gD-4m6tA:
undetectable
2v2gC-4m6tA:
24.18
2v2gD-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 7 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
1.05A 2v2gC-4m6tA:
undetectable
2v2gD-4m6tA:
undetectable
2v2gC-4m6tA:
24.18
2v2gD-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 8 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
0.99A 2v32A-4m6tA:
undetectable
2v32B-4m6tA:
undetectable
2v32A-4m6tA:
24.18
2v32B-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 8 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
0.97A 2v41C-4m6tA:
undetectable
2v41D-4m6tA:
undetectable
2v41C-4m6tA:
24.18
2v41D-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 7 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
0.95A 2v41E-4m6tA:
undetectable
2v41F-4m6tA:
undetectable
2v41E-4m6tA:
24.18
2v41F-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 7 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
0.97A 2v41E-4m6tA:
undetectable
2v41F-4m6tA:
undetectable
2v41E-4m6tA:
24.18
2v41F-4m6tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 8 THR A  40
PRO A  41
VAL A  42
SER A 174
None
SAM  A 201 (-4.7A)
SAM  A 201 (-3.8A)
None
1.03A 2v41G-4m6tA:
undetectable
2v41H-4m6tA:
undetectable
2v41G-4m6tA:
24.18
2v41H-4m6tA:
24.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 4 ILE A  30
VAL A  42
VAL A  44
ARG A 169
SAM  A 201 (-4.2A)
SAM  A 201 (-3.8A)
SAM  A 201 (-4.2A)
SAM  A 201 (-4.3A)
0.02A 4m6tA-4m6tA:
29.3
4m6tA-4m6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo
sapiens)
4 / 6 LYS A 143
ARG A 151
GLU A 147
ALA A  18
None
1.14A 6an0A-4m6tA:
undetectable
6an0A-4m6tA:
16.39