SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m6w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 8 TYR A1976
MET A2000
SER A2003
SER A1995
 None
 0.98A 3lsfH-4m6wA:
undetectable		 3lsfH-4m6wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		3 / 3 ILE A1930
MET A1861
ARG A1860
 None
None
SO4  A2102 ( 3.7A)
 0.72A 4lnwA-4m6wA:
undetectable		 4lnwA-4m6wA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		3 / 3 ILE A1930
MET A1861
ARG A1860
 None
None
SO4  A2102 ( 3.7A)
 0.74A 4lnxA-4m6wA:
undetectable		 4lnxA-4m6wA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 4m6w FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA
(Homo
sapiens) 		5 / 11 TYR B  72
TYR B  60
THR B 108
LEU B 104
LEU B  66
 None
 1.47A 4m7tA-4m6wB:
undetectable		 4m7tA-4m6wB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA
(Homo
sapiens) 		5 / 10 THR B 108
ILE A1932
LEU B  59
VAL B 129
PHE A1934
 None
 1.40A 4r3aB-4m6wB:
undetectable		 4r3aB-4m6wB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		5 / 12 PHE A1880
GLN A1883
ILE A1884
VAL A1863
VAL A1862
 None
 1.00A 4yfbL-4m6wA:
undetectable		 4yfbL-4m6wA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 7 ALA A1942
TYR A1855
VAL A1845
HIS A1841
 None
 1.21A 5ecnA-4m6wA:
undetectable		 5ecnA-4m6wA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		3 / 3 ILE A1979
PRO A1980
ILE A1982
 None
 0.45A 5hw8F-4m6wA:
undetectable		 5hw8F-4m6wA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		5 / 12 GLY A1823
LEU A1945
VAL A1833
ILE A1834
LEU A1887
 SO4  A2101 (-3.5A)
None
None
None
None
 0.94A 5ycnA-4m6wA:
undetectable		 5ycnA-4m6wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 4m6w FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA
(Homo
sapiens) 		5 / 12 ASP B  65
LEU B  66
VAL B  90
VAL B  91
SER B  97
 None
 1.34A 6b50A-4m6wB:
undetectable		 6b50A-4m6wB:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA
(Homo
sapiens) 		4 / 5 ILE A1979
GLN B 165
THR B 162
THR A1986
 None
 1.07A 6f3mD-4m6wA:
2.7		 6f3mD-4m6wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4m6w FANCONI ANEMIA GROUP
M PROTEIN
FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A1933
VAL B 109
HIS A1841
THR A1818
GLY A1815
 None
 1.31A 6mn8A-4m6wA:
undetectable		 6mn8A-4m6wA:
19.68