SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Saccharomyces
cerevisiae) 		5 / 9 GLY E  32
ILE E  12
GLY E  36
ILE E  44
ILE E  22
 None
 1.01A 1hpvA-4m75E:
undetectable		 1hpvA-4m75E:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		4 / 8 HIS D  55
LEU D  63
LEU D  33
SER D  35
 None
 1.12A 1i7zA-4m75D:
undetectable		 1i7zA-4m75D:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 ASN D  25
HIS E  67
SER D  82
ARG E  70
 None
 1.30A 1u1jA-4m75D:
undetectable		 1u1jA-4m75D:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		4 / 5 VAL D  47
ASN D  46
VAL D  78
ILE D  81
 None
 1.07A 1z2bC-4m75D:
undetectable		 1z2bC-4m75D:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS B  50
ASP A 170
ASN B  21
 None
 1.01A 2bm9A-4m75B:
undetectable		 2bm9A-4m75B:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU A 107
MET G  36
ASP A  72
ILE A  46
LEU A  68
 None
 1.21A 2e7fA-4m75A:
undetectable		 2e7fA-4m75A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM4
(Saccharomyces
cerevisiae) 		5 / 10 ILE G  69
GLU G  45
GLU G  23
ILE G  25
ILE G  71
 None
 1.19A 2j9dD-4m75G:
undetectable
2j9dE-4m75G:
undetectable
2j9dF-4m75G:
undetectable		 2j9dD-4m75G:
20.47
2j9dE-4m75G:
20.47
2j9dF-4m75G:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU A 107
MET G  36
ASP A  72
ILE A  46
LEU A  68
 None
 1.22A 2ogyB-4m75A:
undetectable		 2ogyB-4m75A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ARG A  99
GLU A  84
PHE G  78
TRP A 136
 None
 1.36A 2q6uA-4m75A:
undetectable		 2q6uA-4m75A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Saccharomyces
cerevisiae) 		5 / 12 GLY E  32
ILE E  12
GLY E  36
ILE E  44
ILE E  22
 None
 0.82A 3d1xB-4m75E:
undetectable		 3d1xB-4m75E:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Saccharomyces
cerevisiae) 		5 / 12 LEU E  81
GLY E  75
ILE E  44
VAL E  20
ILE E  22
 None
 0.92A 3d20B-4m75E:
undetectable		 3d20B-4m75E:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		5 / 10 VAL D  24
LEU D  73
VAL D  78
VAL D  47
LEU D  49
 None
 1.05A 3gwxA-4m75D:
undetectable		 3gwxA-4m75D:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		4 / 5 THR D  23
SER D  35
SER D  51
ARG D  37
 None
 1.15A 3hlwB-4m75D:
undetectable		 3hlwB-4m75D:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 PHE A  55
ILE B  60
GLY B  55
HIS B  53
 None
 1.29A 3r0lD-4m75A:
undetectable		 3r0lD-4m75A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Saccharomyces
cerevisiae) 		5 / 11 GLY E  32
ILE E  12
GLY E  36
ILE E  44
ILE E  22
 None
 0.92A 4njvC-4m75E:
undetectable		 4njvC-4m75E:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM4
(Saccharomyces
cerevisiae) 		5 / 11 ILE G  17
LEU G   7
LEU G  81
ALA G  10
LEU G  29
 None
 1.05A 4p65E-4m75G:
undetectable
4p65F-4m75G:
undetectable
4p65J-4m75G:
undetectable
4p65L-4m75G:
undetectable		 4p65E-4m75G:
8.60
4p65F-4m75G:
9.84
4p65J-4m75G:
9.84
4p65L-4m75G:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLU A 114
ARG A  52
GLN B  30
 None
 0.88A 4rtbA-4m75A:
undetectable		 4rtbA-4m75A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		4 / 6 TYR D  80
ASN D  25
GLU E  50
GLU D  57
 None
 1.37A 4twdG-4m75D:
undetectable
4twdH-4m75D:
undetectable		 4twdG-4m75D:
12.70
4twdH-4m75D:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2
(Saccharomyces
cerevisiae) 		4 / 4 VAL B  17
ILE B  60
ASN B  37
VAL A 110
 None
 1.21A 5ajqA-4m75B:
undetectable		 5ajqA-4m75B:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLY E  69
GLN E  66
LYS D  85
 None
 0.91A 5imsB-4m75E:
undetectable		 5imsB-4m75E:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		5 / 10 ILE D  41
ILE D  19
PHE D  15
VAL D  47
ASN D  25
 None
 1.24A 5lg3F-4m75D:
undetectable		 5lg3F-4m75D:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		5 / 10 ILE D  41
ILE D  19
PHE D  15
VAL D  47
ASN D  25
 None
 1.19A 5lg3G-4m75D:
undetectable		 5lg3G-4m75D:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		5 / 10 ILE D  41
ILE D  19
PHE D  15
VAL D  47
ASN D  25
 None
 1.21A 5lg3H-4m75D:
undetectable		 5lg3H-4m75D:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
(Saccharomyces
cerevisiae) 		4 / 8 LEU E  21
GLU E  50
LEU E  24
MET D  79
 None
 0.91A 5mzjA-4m75E:
undetectable		 5mzjA-4m75E:
13.95