SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens) 		4 / 4 THR A  96
LEU A 100
VAL A 103
LEU A 107
 None
 0.62A 1fbmD-4m7cA:
undetectable		 1fbmD-4m7cA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens) 		5 / 12 GLU A 112
TYR A  73
PHE A  68
ALA A  64
ASP A  81
 None
 1.31A 3nmuA-4m7cA:
undetectable
3nmuF-4m7cA:
undetectable		 3nmuA-4m7cA:
21.57
3nmuF-4m7cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens) 		5 / 11 PHE A 217
ILE A 177
ILE A 133
VAL A 135
LEU A 136
 None
 1.09A 3w67A-4m7cA:
0.9		 3w67A-4m7cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens) 		5 / 11 LEU A  91
ARG A  54
LEU A  57
LEU A  87
LEU A 101
 None
 1.01A 4wg0B-4m7cA:
undetectable
4wg0C-4m7cA:
undetectable
4wg0D-4m7cA:
undetectable		 4wg0B-4m7cA:
5.00
4wg0C-4m7cA:
5.00
4wg0D-4m7cA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens) 		5 / 11 LEU A  91
ARG A  54
LEU A  57
LEU A  87
LEU A 101
 None
 1.03A 4wg0D-4m7cA:
undetectable
4wg0E-4m7cA:
undetectable
4wg0F-4m7cA:
undetectable		 4wg0D-4m7cA:
5.00
4wg0E-4m7cA:
5.00
4wg0F-4m7cA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens) 		5 / 11 LEU A  91
ARG A  54
LEU A  57
LEU A  87
LEU A 101
 None
 1.05A 4wg0J-4m7cA:
undetectable
4wg0K-4m7cA:
undetectable
4wg0L-4m7cA:
undetectable		 4wg0J-4m7cA:
5.00
4wg0K-4m7cA:
5.00
4wg0L-4m7cA:
5.00