SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 10 LEU A  84
VAL A  86
ILE A 111
LEU A 127
LEU A 104
 None
 1.12A 1cqpA-4m7eA:
undetectable
1cqpB-4m7eA:
undetectable		 1cqpA-4m7eA:
12.87
1cqpB-4m7eA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 7 LEU A 342
LEU A 367
SER A 391
THR A 360
 None
 0.99A 1dvxA-4m7eA:
undetectable		 1dvxA-4m7eA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LEU A 153
VAL A 155
SER A 143
VAL A 194
 None
 1.38A 1ie9A-4m7eA:
undetectable		 1ie9A-4m7eA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 7 LEU A 469
LEU A 442
TYR A 422
LEU A 447
 None
 1.02A 1kt3A-4m7eA:
undetectable		 1kt3A-4m7eA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 ASN A 183
ILE A 185
LEU A 141
ASN A 232
LEU A 160
 None
 1.05A 1liiA-4m7eA:
undetectable		 1liiA-4m7eA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 5 SER A  93
SER A  94
VAL A  45
PHE A  42
 None
 1.46A 1oipA-4m7eA:
undetectable		 1oipA-4m7eA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 7 GLY A 325
PHE A 328
ASN A 351
ASN A 350
 None
 0.99A 1oniG-4m7eA:
1.7
1oniI-4m7eA:
undetectable		 1oniG-4m7eA:
10.62
1oniI-4m7eA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 5 PHE A 658
LEU A 707
MET A 677
LEU A 556
 None
 1.41A 1skxA-4m7eA:
undetectable		 1skxA-4m7eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 714
LEU A 738
ASN A 736
LEU A 762
MET A 722
 None
 1.45A 1sqnA-4m7eA:
undetectable		 1sqnA-4m7eA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 11 ASN A 132
ILE A 111
LYS A  82
LEU A  84
PHE A  42
 None
 1.39A 1tw4A-4m7eA:
undetectable		 1tw4A-4m7eA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 556
ILE A 552
ILE A 576
LEU A 567
LEU A 562
 None
 1.01A 1xdkB-4m7eA:
undetectable		 1xdkB-4m7eA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 556
ILE A 552
ILE A 576
LEU A 567
LEU A 562
 None
 1.01A 1xdkF-4m7eA:
undetectable		 1xdkF-4m7eA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 10 ALA A 314
LEU A 290
PHE A 310
PHE A 336
LEU A 288
 None
 1.46A 1y7iB-4m7eA:
undetectable		 1y7iB-4m7eA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 5 ILE A 540
ILE A 504
ILE A 494
LEU A 556
 None
 0.91A 1zgyA-4m7eA:
undetectable		 1zgyA-4m7eA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 298
LEU A 347
ALA A 346
SER A 344
LEU A 342
 None
 1.13A 2aa5B-4m7eA:
undetectable		 2aa5B-4m7eA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 421
LEU A 423
THR A 386
LEU A 388
SER A 389
 None
 1.02A 2bdmA-4m7eA:
undetectable		 2bdmA-4m7eA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 423
LEU A 385
THR A 386
LEU A 388
SER A 389
 None
 1.05A 2bdmA-4m7eA:
undetectable		 2bdmA-4m7eA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 7 SER A 156
SER A 157
SER A 130
ASN A 154
 NAG  A 801 (-3.5A)
NAG  A 802 ( 3.8A)
NAG  A 801 (-3.3A)
NAG  A 801 (-1.8A)
 1.08A 2cmlA-4m7eA:
undetectable		 2cmlA-4m7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 7 SER A 277
SER A 278
SER A 253
ASN A 275
 NAG  A 803 (-3.1A)
NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-1.7A)
 1.04A 2cmlA-4m7eA:
undetectable		 2cmlA-4m7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 8 SER A 277
SER A 278
SER A 253
ASN A 275
 NAG  A 803 (-3.1A)
NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-1.7A)
 0.96A 2cmlB-4m7eA:
undetectable		 2cmlB-4m7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 8 SER A 156
SER A 157
SER A 130
ASN A 154
 NAG  A 801 (-3.5A)
NAG  A 802 ( 3.8A)
NAG  A 801 (-3.3A)
NAG  A 801 (-1.8A)
 1.07A 2cmlC-4m7eA:
undetectable		 2cmlC-4m7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 8 SER A 277
SER A 278
SER A 253
ASN A 275
 NAG  A 803 (-3.1A)
NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-1.7A)
 1.01A 2cmlC-4m7eA:
undetectable		 2cmlC-4m7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 8 SER A 277
SER A 278
SER A 253
ASN A 275
 NAG  A 803 (-3.1A)
NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-1.7A)
 1.09A 2cmlD-4m7eA:
undetectable		 2cmlD-4m7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A  96
GLY A 100
LEU A 127
THR A 125
LEU A 150
 None
 1.04A 2egvB-4m7eA:
undetectable		 2egvB-4m7eA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 604
ASP A 708
ILE A 706
GLY A 613
ILE A 600
 None
None
BLD  A 808 (-4.9A)
None
None
 0.97A 2hs1A-4m7eA:
undetectable		 2hs1A-4m7eA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 604
ASP A 708
ILE A 706
GLY A 613
ILE A 600
 None
None
BLD  A 808 (-4.9A)
None
None
 0.93A 2rkgB-4m7eA:
undetectable		 2rkgB-4m7eA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 714
LEU A 738
ASN A 736
LEU A 762
MET A 722
 None
 1.40A 2w8yB-4m7eA:
undetectable		 2w8yB-4m7eA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		3 / 3 GLY A 668
TYR A 669
SER A 691
 None
 0.66A 2xatA-4m7eA:
undetectable		 2xatA-4m7eA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 11 ALA A 314
LEU A 298
LEU A 323
SER A 312
LEU A 311
 None
 1.10A 2xn5A-4m7eA:
undetectable		 2xn5A-4m7eA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		6 / 12 ILE A 674
LEU A 683
ILE A 670
MET A 661
MET A 677
PHE A 581
 None
 1.20A 2ygnA-4m7eA:
undetectable		 2ygnA-4m7eA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 714
LEU A 738
ASN A 736
LEU A 762
MET A 722
 None
 1.41A 3d90A-4m7eA:
undetectable		 3d90A-4m7eA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 311
ILE A 285
LEU A 298
ASP A 322
PHE A 352
 None
 1.21A 3ko0A-4m7eA:
undetectable
3ko0B-4m7eA:
undetectable
3ko0C-4m7eA:
undetectable
3ko0D-4m7eA:
undetectable		 3ko0A-4m7eA:
8.34
3ko0B-4m7eA:
8.34
3ko0C-4m7eA:
8.34
3ko0D-4m7eA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 298
ASP A 322
LEU A 311
ILE A 285
PHE A 352
 None
 1.25A 3ko0K-4m7eA:
undetectable
3ko0L-4m7eA:
undetectable
3ko0M-4m7eA:
undetectable
3ko0N-4m7eA:
undetectable		 3ko0K-4m7eA:
8.34
3ko0L-4m7eA:
8.34
3ko0M-4m7eA:
8.34
3ko0N-4m7eA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 192
VAL A 218
ALA A 188
GLY A 214
ILE A 207
 None
 1.03A 3ku1G-4m7eA:
undetectable		 3ku1G-4m7eA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 ASP A 316
PHE A 336
LEU A 321
PHE A 261
ILE A 265
 None
 0.97A 3pwwA-4m7eA:
undetectable		 3pwwA-4m7eA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 7 VAL A  74
LEU A  98
PHE A  64
LEU A  52
 None
 1.05A 3qeoB-4m7eA:
undetectable		 3qeoB-4m7eA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 VAL A 332
ALA A 331
GLY A 330
TYR A 329
LEU A 345
 None
 1.17A 3qxyA-4m7eA:
undetectable		 3qxyA-4m7eA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 11 VAL A 332
ALA A 331
GLY A 330
TYR A 329
LEU A 345
 None
 1.15A 3rc0A-4m7eA:
undetectable		 3rc0A-4m7eA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 VAL A 332
ALA A 331
GLY A 330
TYR A 329
LEU A 345
 None
 1.15A 3rc0B-4m7eA:
undetectable		 3rc0B-4m7eA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 5 LEU A 738
ILE A 742
PRO A 743
PHE A 748
 None
 1.16A 3s3vA-4m7eA:
undetectable		 3s3vA-4m7eA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 VAL A 216
ILE A 252
ASN A 255
SER A 253
HIS A 249
 None
None
None
NAG  A 803 (-2.3A)
None
 1.39A 4c49B-4m7eA:
undetectable		 4c49B-4m7eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 VAL A 191
LEU A 202
SER A 208
PHE A 226
VAL A 216
 None
 1.15A 4eckB-4m7eA:
undetectable		 4eckB-4m7eA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7e BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 ASP D 122
LEU D 121
ILE D 132
PRO D 133
LEU D 160
 None
 1.16A 4gh8A-4m7eD:
undetectable		 4gh8A-4m7eD:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 447
LEU A 452
SER A 453
THR A 455
 None
 1.02A 4i89A-4m7eA:
undetectable		 4i89A-4m7eA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4m7e BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		4 / 5 LEU D 139
SER D 120
LEU D  94
LEU D 136
 None
 1.26A 4n09B-4m7eD:
undetectable		 4n09B-4m7eD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 6 ILE A 517
ILE A 552
ILE A 504
LEU A 535
 None
 0.75A 4o8fB-4m7eA:
undetectable		 4o8fB-4m7eA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 11 LEU A 127
VAL A  91
SER A  92
LEU A  95
LEU A 124
 None
 1.03A 4or0B-4m7eA:
undetectable		 4or0B-4m7eA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 556
GLY A 557
LEU A 538
ILE A 576
PHE A 581
 None
 1.25A 4p6xA-4m7eA:
undetectable		 4p6xA-4m7eA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 556
GLY A 557
LEU A 538
ILE A 576
PHE A 581
 None
 1.24A 4p6xE-4m7eA:
undetectable		 4p6xE-4m7eA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 4 PHE A 374
ASP A 371
GLY A 620
SER A 348
 None
None
SO4  A 807 ( 4.8A)
None
 1.20A 4xp9C-4m7eA:
undetectable		 4xp9C-4m7eA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 447
LEU A 452
SER A 453
THR A 455
 None
 0.98A 5bojA-4m7eA:
undetectable		 5bojA-4m7eA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 PRO A 357
LEU A 356
GLY A 337
LEU A 342
LEU A 370
 None
 1.43A 5emlA-4m7eA:
undetectable		 5emlA-4m7eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 4 LEU A 469
TYR A 486
PRO A 481
ILE A 480
 None
 1.38A 5esgA-4m7eA:
undetectable		 5esgA-4m7eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4m7e BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 VAL D  62
LEU D 118
LEU D  97
LEU D 115
THR D 116
 None
 1.00A 5hnwB-4m7eD:
undetectable		 5hnwB-4m7eD:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4m7e BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 VAL D  62
LEU D 118
LEU D  97
LEU D 115
THR D 116
 None
 1.09A 5hnyB-4m7eD:
undetectable		 5hnyB-4m7eD:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 5 SER A 278
SER A 253
SER A 277
SER A 231
 NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-3.1A)
NAG  A 803 ( 4.5A)
 1.44A 5hswA-4m7eA:
undetectable		 5hswA-4m7eA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 6 VAL A 282
SER A 258
ILE A 276
PHE A 261
 None
 0.98A 5jw1B-4m7eA:
undetectable		 5jw1B-4m7eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 4 ASN A 132
LEU A 134
SER A 156
LEU A 153
 None
None
NAG  A 801 (-3.5A)
None
 1.11A 5kb5A-4m7eA:
undetectable		 5kb5A-4m7eA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 447
LEU A 452
SER A 453
THR A 455
 None
 1.01A 5l4iA-4m7eA:
undetectable		 5l4iA-4m7eA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 10 LEU A 680
ILE A 576
PHE A 581
LEU A 541
LEU A 562
 None
 0.93A 5y7pB-4m7eA:
undetectable		 5y7pB-4m7eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 10 LEU A 680
ILE A 576
PHE A 581
LEU A 541
LEU A 562
 None
 0.95A 5y7pD-4m7eA:
undetectable		 5y7pD-4m7eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 10 LEU A 680
ILE A 576
PHE A 581
LEU A 541
LEU A 562
 None
 0.92A 5y7pH-4m7eA:
undetectable		 5y7pH-4m7eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 466
LEU A 460
PRO A 505
GLY A 507
LEU A 508
 None
 1.18A 6b0lB-4m7eA:
undetectable		 6b0lB-4m7eA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		4 / 7 SER A 734
SER A 711
HIS A 687
GLY A 686
 None
 0.96A 6btxA-4m7eA:
undetectable		 6btxA-4m7eA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 10 LEU A 709
LEU A 666
ILE A 694
PRO A 695
SER A 691
 None
 1.47A 6dlzB-4m7eA:
undetectable
6dlzC-4m7eA:
undetectable		 6dlzB-4m7eA:
7.47
6dlzC-4m7eA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 10 LEU A 709
LEU A 666
ILE A 694
PRO A 695
SER A 691
 None
 1.47A 6dm1B-4m7eA:
undetectable
6dm1C-4m7eA:
undetectable		 6dm1B-4m7eA:
7.47
6dm1C-4m7eA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 12 ASN A 570
ASN A 521
GLY A 613
ASP A 660
ILE A 540
 None
NAG  A 805 ( 4.5A)
None
None
None
 1.25A 6dwnA-4m7eA:
undetectable		 6dwnA-4m7eA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1
(Arabidopsis
thaliana) 		5 / 9 LEU A 680
SER A 584
GLY A 654
ILE A 587
PHE A 650
 None
 1.33A 6ebpA-4m7eA:
undetectable		 6ebpA-4m7eA:
7.20