SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A 304
GLY A 316
ASP A 391
ASP A 300
 None
 0.84A 1m4iA-4m7fA:
undetectable		 1m4iA-4m7fA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ASP A 274
THR A 277
ARG A 287
GLU A 451
LYS A 453
 None
 1.26A 2j1gE-4m7fA:
36.9
2j1gF-4m7fA:
36.9		 2j1gE-4m7fA:
50.44
2j1gF-4m7fA:
50.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ASN A 400
ALA A 402
ALA A 403
ARG A 406
 None
 0.76A 3kp2B-4m7fA:
undetectable		 3kp2B-4m7fA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 323
TYR A 329
PRO A 241
ASP A 274
ASP A 255
 None
 1.42A 4j7xJ-4m7fA:
undetectable		 4j7xJ-4m7fA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 377
TRP A 282
SER A 417
 None
 1.05A 4lrhA-4m7fA:
undetectable		 4lrhA-4m7fA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 354
GLY A 353
ILE A 454
LEU A 323
THR A 324
 None
 1.17A 4x3mB-4m7fA:
undetectable		 4x3mB-4m7fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 303
ASP A 300
TRP A 299
 None
 1.13A 4xdqA-4m7fA:
undetectable		 4xdqA-4m7fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLY A 280
ASP A 274
ARG A 276
GLN A 252
 None
 1.18A 5zrfB-4m7fA:
undetectable		 5zrfB-4m7fA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TRP A 410
PHE A 350
VAL A 333
SER A 450
TYR A 302
 None
 1.37A 6cm4A-4m7fA:
undetectable		 6cm4A-4m7fA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 415
LEU A 447
TYR A 445
GLY A 442
 BM3  A 503 (-3.8A)
None
None
None
 1.34A 6n91A-4m7fA:
undetectable		 6n91A-4m7fA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 415
LEU A 447
TYR A 445
GLY A 442
 BM3  A 503 (-3.8A)
None
None
None
 1.34A 6n91B-4m7fA:
undetectable		 6n91B-4m7fA:
14.73