SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4m7r ANAMORSIN
(Homo
sapiens) 		3 / 3 ALA A  37
VAL A  68
TRP A  40
 None
 0.91A 1av2A-4m7rA:
undetectable
1av2B-4m7rA:
undetectable		 1av2A-4m7rA:
9.91
1av2B-4m7rA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4m7r ANAMORSIN
(Homo
sapiens) 		3 / 3 TRP A  40
ALA A  37
VAL A  68
 None
 0.98A 1av2C-4m7rA:
undetectable
1av2D-4m7rA:
undetectable		 1av2C-4m7rA:
9.91
1av2D-4m7rA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4m7r ANAMORSIN
(Homo
sapiens) 		4 / 8 GLU A 106
ARG A 109
LEU A  74
GLU A  69
 None
 1.03A 1cmaA-4m7rA:
undetectable
1cmaB-4m7rA:
undetectable		 1cmaA-4m7rA:
21.84
1cmaB-4m7rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4m7r ANAMORSIN
(Homo
sapiens) 		4 / 8 CYH A 116
GLY A 115
GLY A 114
GLN A  34
 HG  A 201 (-2.3A)
None
None
None
 0.90A 1ekjA-4m7rA:
undetectable
1ekjB-4m7rA:
undetectable		 1ekjA-4m7rA:
21.03
1ekjB-4m7rA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4m7r ANAMORSIN
(Homo
sapiens) 		3 / 3 ALA A  37
VAL A  68
TRP A  40
 None
 0.90A 1w5uA-4m7rA:
undetectable
1w5uB-4m7rA:
undetectable		 1w5uA-4m7rA:
9.91
1w5uB-4m7rA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4m7r ANAMORSIN
(Homo
sapiens) 		3 / 3 TRP A  40
ALA A  37
VAL A  68
 None
 0.93A 1w5uA-4m7rA:
undetectable
1w5uB-4m7rA:
undetectable		 1w5uA-4m7rA:
9.91
1w5uB-4m7rA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4m7r ANAMORSIN
(Homo
sapiens) 		5 / 11 HIS A  99
ILE A 103
ASN A  70
VAL A  68
SER A  89
 None
 1.39A 2zweA-4m7rA:
undetectable
2zweB-4m7rA:
undetectable		 2zweA-4m7rA:
19.80
2zweB-4m7rA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4m7r ANAMORSIN
(Homo
sapiens) 		5 / 10 VAL A  92
GLY A  90
VAL A  53
GLN A  57
ILE A  71
 None
 1.34A 3km6A-4m7rA:
undetectable		 3km6A-4m7rA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4m7r ANAMORSIN
(Homo
sapiens) 		3 / 3 TRP A  40
ALA A  37
VAL A  68
 None
 1.00A 3l8lC-4m7rA:
undetectable
3l8lD-4m7rA:
undetectable		 3l8lC-4m7rA:
9.91
3l8lD-4m7rA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4m7r ANAMORSIN
(Homo
sapiens) 		5 / 10 LEU A 143
ALA A 108
ILE A  86
VAL A 151
LEU A 148
 None
 0.91A 3ogpB-4m7rA:
undetectable		 3ogpB-4m7rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 4m7r ANAMORSIN
(Homo
sapiens) 		5 / 10 LEU A  88
ALA A  26
PHE A  28
GLY A  29
ILE A  86
 None
 1.39A 3qpsA-4m7rA:
undetectable		 3qpsA-4m7rA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4m7r ANAMORSIN
(Homo
sapiens) 		5 / 12 LEU A 117
LEU A 139
SER A 146
LEU A 104
SER A  89
 None
 1.49A 4zbrA-4m7rA:
undetectable		 4zbrA-4m7rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 4m7r ANAMORSIN
(Homo
sapiens) 		5 / 11 HIS A  99
ILE A 103
ASN A  70
VAL A  68
SER A  89
 None
 1.33A 5z0gA-4m7rA:
undetectable
5z0gB-4m7rA:
undetectable		 5z0gA-4m7rA:
16.92
5z0gB-4m7rA:
14.57