SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		5 / 12 ALA A 130
ALA A 131
ILE A 171
CYH A 185
LEU A 178
 None
 1.04A 1fm6U-4m87A:
undetectable		 1fm6U-4m87A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1kifA-4m87A:
4.1		 1kifA-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1kifB-4m87A:
4.7		 1kifB-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1kifC-4m87A:
4.6		 1kifC-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.13A 1kifD-4m87A:
4.1		 1kifD-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1kifE-4m87A:
4.7		 1kifE-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1kifF-4m87A:
4.7		 1kifF-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1kifG-4m87A:
4.7		 1kifG-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1kifH-4m87A:
4.7		 1kifH-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.14A 1ve9A-4m87A:
4.7		 1ve9A-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.22A 2du8J-4m87A:
4.7		 2du8J-4m87A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 8 SER A 238
ALA A 230
CYH A  28
ILE A   9
 None
 0.89A 3bpxA-4m87A:
undetectable
3bpxB-4m87A:
undetectable		 3bpxA-4m87A:
19.08
3bpxB-4m87A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 4 ILE A  24
GLN A  31
ILE A 223
LEU A 237
 None
 1.34A 3dzyD-4m87A:
undetectable		 3dzyD-4m87A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		5 / 10 LEU A 233
GLY A 240
ASN A 139
GLY A 179
VAL A 143
 None
 0.84A 3lzvA-4m87A:
undetectable		 3lzvA-4m87A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		5 / 12 LEU A  88
ALA A 144
ILE A 188
GLY A 243
SER A 140
 None
 1.02A 3ogqB-4m87A:
undetectable		 3ogqB-4m87A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 8 LEU A 234
ASN A 139
GLY A 182
ILE A 183
 None
 0.78A 3wxoA-4m87A:
undetectable		 3wxoA-4m87A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		5 / 12 LEU A 124
LEU A 127
ALA A 130
MET A 135
THR A 174
 None
 1.27A 4fn9B-4m87A:
undetectable		 4fn9B-4m87A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 6 VAL A 226
SER A  91
ALA A 198
PHE A 204
 None
NAD  A 301 (-3.1A)
NAD  A 301 ( 3.9A)
None
 0.94A 4nedA-4m87A:
undetectable		 4nedA-4m87A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		4 / 4 VAL A 151
GLU A 168
GLY A 149
LEU A 148
 None
 1.28A 5g5gC-4m87A:
undetectable		 5g5gC-4m87A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		5 / 9 ALA A  33
GLN A   5
GLU A  30
LEU A  35
ILE A   9
 None
 1.30A 5i73A-4m87A:
undetectable		 5i73A-4m87A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		5 / 12 LEU A 145
THR A  12
ALA A  21
ILE A 223
ILE A  24
 NAD  A 301 (-3.9A)
None
None
None
None
 0.93A 5xiwB-4m87A:
7.0		 5xiwB-4m87A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Neisseria
meningitidis) 		5 / 12 ALA A 231
GLY A 227
GLY A  23
LEU A 237
PHE A   3
 None
 1.17A 5ybbA-4m87A:
4.9		 5ybbA-4m87A:
20.31