SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		3 / 3 THR A 150
THR A 152
PRO A 149
 GOL  A 402 (-3.6A)
None
None
 0.84A 1dscC-4m88A:
undetectable		 1dscC-4m88A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
 None
 1.00A 1fm6A-4m88A:
undetectable		 1fm6A-4m88A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		4 / 6 LEU A  21
ASP A  17
LEU A  14
GLU A 287
 None
 1.06A 1mt1A-4m88A:
undetectable
1mt1F-4m88A:
undetectable		 1mt1A-4m88A:
10.00
1mt1F-4m88A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		4 / 5 GLU A 287
LEU A  21
ASP A  17
LEU A  14
 None
 1.01A 1n13B-4m88A:
undetectable
1n13C-4m88A:
undetectable		 1n13B-4m88A:
14.57
1n13C-4m88A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		4 / 7 LEU A  21
ASP A  17
LEU A  14
GLU A 287
 None
 0.99A 1n13I-4m88A:
undetectable
1n13L-4m88A:
undetectable		 1n13I-4m88A:
10.00
1n13L-4m88A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 GLY A 248
VAL A 250
LEU A 136
MET A 138
LEU A 141
 None
 1.18A 1nhzA-4m88A:
undetectable		 1nhzA-4m88A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		3 / 3 GLN A 251
ILE A 343
TYR A 354
 None
 0.74A 1vifA-4m88A:
undetectable		 1vifA-4m88A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
 None
 1.01A 1xiuA-4m88A:
undetectable		 1xiuA-4m88A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 11 LEU A  43
ILE A  38
LEU A  90
VAL A  97
MET A  65
 None
 1.45A 2n27A-4m88A:
undetectable		 2n27A-4m88A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		3 / 3 VAL A 157
GLU A 127
GLU A 160
 None
 0.75A 2nv4A-4m88A:
undetectable		 2nv4A-4m88A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 10 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
 None
 1.03A 3falC-4m88A:
undetectable		 3falC-4m88A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 VAL A 101
GLY A 100
GLY A 288
ALA A  18
ALA A  19
 None
 1.01A 3sufD-4m88A:
undetectable		 3sufD-4m88A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 9 LEU A 144
LEU A 215
ILE A 235
ILE A 249
PHE A 207
 None
 1.26A 3tmzA-4m88A:
undetectable		 3tmzA-4m88A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 11 ILE A 322
ASP A 323
ILE A 324
GLY A 326
ARG A 108
 None
 0.72A 4ac9B-4m88A:
4.7
4ac9C-4m88A:
5.9		 4ac9B-4m88A:
21.22
4ac9C-4m88A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 GLU A 287
PHE A 284
ILE A 324
SER A  74
GLN A   6
 None
 1.49A 4djfB-4m88A:
undetectable		 4djfB-4m88A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		6 / 12 GLY A 288
GLY A  24
ASP A 323
GLY A 325
PRO A 254
LEU A 261
 None
 1.49A 4fp9D-4m88A:
undetectable		 4fp9D-4m88A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		6 / 12 GLY A 288
GLY A  24
ASP A 323
GLY A 325
PRO A 254
LEU A 261
 None
 1.46A 4fzvA-4m88A:
3.1		 4fzvA-4m88A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 PHE A 116
ALA A 310
ALA A 313
ALA A 314
THR A 318
 None
 1.06A 4j6dA-4m88A:
undetectable		 4j6dA-4m88A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 PHE A 116
ALA A 310
ALA A 313
ALA A 314
THR A 318
 None
 1.06A 4j6dB-4m88A:
undetectable		 4j6dB-4m88A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 PHE A 116
ALA A 310
ALA A 313
ALA A 314
THR A 318
 None
 1.07A 4jbtA-4m88A:
1.4		 4jbtA-4m88A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		4 / 7 GLU A 283
ILE A 235
LEU A 184
ILE A 208
 GOL  A 403 (-2.9A)
None
None
None
 0.98A 4xumA-4m88A:
undetectable		 4xumA-4m88A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		4 / 5 ALA A 233
GLU A 280
ASN A 257
GLU A 283
 GOL  A 403 (-3.4A)
GOL  A 403 (-4.5A)
GOL  A 403 (-3.9A)
GOL  A 403 (-2.9A)
 1.49A 5dwkC-4m88A:
undetectable		 5dwkC-4m88A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		4 / 5 LEU A 107
GLY A 100
ASP A  50
ILE A   7
 None
 0.84A 5ik1A-4m88A:
undetectable		 5ik1A-4m88A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
 None
 0.99A 5uanA-4m88A:
undetectable		 5uanA-4m88A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
 None
 1.02A 5z12C-4m88A:
undetectable		 5z12C-4m88A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Verminephrobacte
r
eiseniae) 		4 / 5 GLY A   8
ASP A  49
GLN A  23
MET A 278
 None
 1.24A 5zrfB-4m88A:
2.3		 5zrfB-4m88A:
17.45