SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 11 ILE A 459
ALA A 475
ILE A  40
LEU A  33
ILE A 462
 None
 1.20A 1dg5A-4m8jA:
undetectable		 1dg5A-4m8jA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 9 LEU A 265
SER A 266
THR A 100
LEU A 105
ALA A 418
 None
 1.31A 1fo4A-4m8jA:
undetectable		 1fo4A-4m8jA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 MET A 408
PHE A 411
SER A 109
ILE A 395
 None
 0.91A 1fxhA-4m8jA:
undetectable
1fxhB-4m8jA:
undetectable		 1fxhA-4m8jA:
18.32
1fxhB-4m8jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 6 TYR A 327
VAL A 456
ILE A 459
LEU A 483
 NM2  A 601 (-4.4A)
None
None
None
 1.21A 1j96A-4m8jA:
undetectable		 1j96A-4m8jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 PHE A 160
TYR A 159
LEU A 492
LEU A 178
PRO A 177
 None
 1.47A 1p33C-4m8jA:
undetectable		 1p33C-4m8jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 MET A 408
PHE A 411
SER A 109
ILE A 395
 None
 0.96A 1pnlA-4m8jA:
undetectable
1pnlB-4m8jA:
undetectable		 1pnlA-4m8jA:
18.32
1pnlB-4m8jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 VAL A 448
VAL A 247
ARG A 170
CYH A 426
 None
 1.22A 1t46A-4m8jA:
undetectable		 1t46A-4m8jA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 5 LEU A 105
LEU A 270
LEU A 268
LEU A 366
 None
 1.13A 1yajD-4m8jA:
undetectable		 1yajD-4m8jA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 PHE A 152
ILE A 495
GLY A  65
TRP A  68
 None
 0.88A 2y7kA-4m8jA:
undetectable		 2y7kA-4m8jA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 TYR A 285
ILE A 374
PHE A 312
ALA A 136
SER A 289
 None
 1.44A 3apwA-4m8jA:
undetectable		 3apwA-4m8jA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 10 ILE A 476
ILE A 477
VAL A  47
GLY A  52
TYR A  58
 None
 1.01A 3elzC-4m8jA:
undetectable		 3elzC-4m8jA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 LEU A 371
PHE A 281
ILE A 282
SER A 289
LEU A 139
 None
 1.17A 3n8xA-4m8jA:
0.4		 3n8xA-4m8jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 ILE A 235
ILE A 236
THR A 419
ILE A 423
 None
 0.66A 3p4wC-4m8jA:
2.4		 3p4wC-4m8jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 GLU A 111
GLY A 108
ILE A 394
GLY A 367
ASN A 369
 None
 1.09A 3ps9A-4m8jA:
undetectable		 3ps9A-4m8jA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 ASP A 193
VAL A 179
VAL A 486
VAL A 192
 None
 0.73A 3ufnB-4m8jA:
undetectable		 3ufnB-4m8jA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 9 LEU A 265
SER A 266
THR A 100
LEU A 105
ALA A 418
 None
 1.30A 3unaA-4m8jA:
undetectable		 3unaA-4m8jA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 9 LEU A 265
SER A 266
THR A 100
LEU A 105
ALA A 418
 None
 1.29A 3unaB-4m8jA:
undetectable		 3unaB-4m8jA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 9 LEU A 265
SER A 266
THR A 100
LEU A 105
ALA A 418
 None
 1.32A 3uncA-4m8jA:
undetectable		 3uncA-4m8jA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 9 LEU A 265
SER A 266
THR A 100
LEU A 105
ALA A 418
 None
 1.32A 3uncB-4m8jA:
undetectable		 3uncB-4m8jA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 LEU A 265
THR A 100
LEU A 105
ALA A 418
 None
 0.88A 3uniB-4m8jA:
undetectable		 3uniB-4m8jA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_A_ACTA511_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 4 ASN A 284
PHE A 281
SER A 280
GLN A 372
 None
 1.35A 3v5vA-4m8jA:
undetectable		 3v5vA-4m8jA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 LEU A 401
VAL A 276
LEU A 105
LEU A 366
 None
 0.92A 4l1xA-4m8jA:
undetectable		 4l1xA-4m8jA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 PHE A 411
ILE A 365
GLY A 108
THR A 370
VAL A 273
 None
 1.00A 4nkxA-4m8jA:
undetectable		 4nkxA-4m8jA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 ASN A 487
ALA A 203
GLY A 479
ILE A 201
GLY A 205
 None
 1.06A 4obwB-4m8jA:
undetectable		 4obwB-4m8jA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 LEU A 403
LEU A 268
MET A 269
VAL A 273
ILE A 413
 None
 0.98A 4ok1A-4m8jA:
undetectable		 4ok1A-4m8jA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 LEU A 403
LEU A 268
MET A 269
VAL A 273
ILE A 413
 None
 0.96A 4okbA-4m8jA:
undetectable		 4okbA-4m8jA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		6 / 12 ALA A 322
ALA A 315
PHE A 319
THR A 206
ILE A 472
TYR A 327
 None
None
None
None
None
NM2  A 601 (-4.4A)
 1.45A 4pssA-4m8jA:
undetectable		 4pssA-4m8jA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 VAL A  22
GLY A 205
GLY A 460
ILE A 459
ILE A 423
 None
 0.81A 4q5mA-4m8jA:
undetectable		 4q5mA-4m8jA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.45A 4tzcB-4m8jA:
undetectable
4tzcD-4m8jA:
undetectable		 4tzcB-4m8jA:
11.60
4tzcD-4m8jA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.33A 4tzuB-4m8jA:
undetectable
4tzuC-4m8jA:
undetectable		 4tzuB-4m8jA:
11.11
4tzuC-4m8jA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.34A 4tzuB-4m8jA:
undetectable
4tzuC-4m8jA:
undetectable		 4tzuB-4m8jA:
11.11
4tzuC-4m8jA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 ILE A 235
ILE A 236
THR A 419
ILE A 423
 None
 0.61A 5murB-4m8jA:
2.4		 5murB-4m8jA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 ILE A 461
LEU A 464
TRP A 239
GLY A 457
GLY A 205
 None
 1.24A 5nnaA-4m8jA:
undetectable		 5nnaA-4m8jA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 ILE A 461
LEU A 464
TRP A 239
GLY A 457
GLY A 205
 None
 1.22A 5nnaD-4m8jA:
undetectable		 5nnaD-4m8jA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.42A 5yizG-4m8jA:
undetectable
5yizY-4m8jA:
undetectable		 5yizG-4m8jA:
9.07
5yizY-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.38A 5yizk-4m8jA:
undetectable
5yizt-4m8jA:
undetectable		 5yizk-4m8jA:
9.07
5yizt-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.43A 5yizk-4m8jA:
undetectable
5yizt-4m8jA:
undetectable		 5yizk-4m8jA:
9.07
5yizt-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.40A 5yizG-4m8jA:
undetectable
5yizY-4m8jA:
undetectable		 5yizG-4m8jA:
9.07
5yizY-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.46A 5yj0G-4m8jA:
undetectable
5yj0Y-4m8jA:
undetectable		 5yj0G-4m8jA:
9.07
5yj0Y-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.41A 5yj0k-4m8jA:
undetectable
5yj0t-4m8jA:
undetectable		 5yj0k-4m8jA:
9.07
5yj0t-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.43A 5yj0k-4m8jA:
undetectable
5yj0t-4m8jA:
undetectable		 5yj0k-4m8jA:
9.07
5yj0t-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.42A 5yj0G-4m8jA:
undetectable
5yj0Y-4m8jA:
undetectable		 5yj0G-4m8jA:
9.07
5yj0Y-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.41A 5yj1G-4m8jA:
undetectable
5yj1Y-4m8jA:
undetectable		 5yj1G-4m8jA:
12.10
5yj1Y-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.40A 5yj1k-4m8jA:
undetectable
5yj1t-4m8jA:
undetectable		 5yj1k-4m8jA:
12.10
5yj1t-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.34A 5yj1k-4m8jA:
undetectable
5yj1t-4m8jA:
undetectable		 5yj1k-4m8jA:
12.10
5yj1t-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.43A 5yj1G-4m8jA:
undetectable
5yj1Y-4m8jA:
undetectable		 5yj1G-4m8jA:
12.10
5yj1Y-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 PHE A 162
ARG A  78
LEU A  79
ALA A 336
 None
 1.29A 6b89A-4m8jA:
undetectable		 6b89A-4m8jA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 PHE A 485
GLY A 480
PHE A  55
VAL A  50
TYR A  46
 None
 1.14A 6drzA-4m8jA:
2.1		 6drzA-4m8jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		5 / 12 THR A 206
GLY A 205
LEU A 202
VAL A  22
GLN A 330
 None
 1.12A 6gngA-4m8jA:
undetectable		 6gngA-4m8jA:
23.43