SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA8_0
(GRAMICIDIN A
MINI-GRAMICIDIN A)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		4 / 4 VAL A 211
TRP A  67
TRP A  68
GLY A 213
 None
 1.17A 1tkqA-4m8kA:
undetectable
1tkqB-4m8kA:
undetectable		 1tkqA-4m8kA:
3.07
1tkqB-4m8kA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		4 / 5 GLY A 213
VAL A 211
TRP A  67
TRP A  68
 None
 1.32A 1tkqB-4m8kA:
undetectable		 1tkqB-4m8kA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		5 / 9 LEU A 156
LEU A 157
ILE A 169
ILE A 109
TYR A 164
 None
 1.24A 2f7aB-4m8kA:
undetectable		 2f7aB-4m8kA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		5 / 12 LEU A 112
GLY A 113
TYR A 164
ILE A 118
ASP A 116
 None
 1.01A 3gwvA-4m8kA:
undetectable		 3gwvA-4m8kA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		5 / 12 LEU A 112
GLY A 113
TYR A 164
ILE A 118
ASP A 116
 None
 1.02A 3gwwA-4m8kA:
undetectable		 3gwwA-4m8kA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		5 / 11 GLU A  74
PHE A  71
ILE A 172
LEU A 119
VAL A 225
 None
 1.12A 3n0hA-4m8kA:
undetectable		 3n0hA-4m8kA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		5 / 12 GLU A  74
PHE A  71
ILE A 172
LEU A 119
VAL A 225
 None
 1.12A 3s3vA-4m8kA:
undetectable		 3s3vA-4m8kA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Bacteroides
uniformis) 		3 / 3 ASN A 125
TYR A 100
CYH A  91
 ACT  A 301 (-2.8A)
None
None
 0.97A 5lsuB-4m8kA:
undetectable		 5lsuB-4m8kA:
20.73