SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4m8n RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens) 		3 / 3 PHE E  28
LEU E  19
SER E 147
 GDP  E 201 (-4.7A)
None
GDP  E 201 (-3.7A)
 0.79A 1e7aA-4m8nE:
undetectable		 1e7aA-4m8nE:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 7 PHE A1002
VAL A 737
VAL A1013
ILE A1006
 None
 0.98A 1p7rA-4m8nA:
undetectable		 1p7rA-4m8nA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 8 TYR A1063
TYR A1056
TRP A 957
LEU A 744
 None
 1.46A 1uw6A-4m8nA:
undetectable
1uw6B-4m8nA:
undetectable		 1uw6A-4m8nA:
17.71
1uw6B-4m8nA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4m8n RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens) 		5 / 12 THR E  35
GLY E  15
GLY E  13
GLY E  60
ASP E 119
 MG  E 200 (-2.7A)
GDP  E 201 (-3.6A)
GDP  E 201 ( 3.1A)
AF3  E 202 (-3.3A)
GDP  E 201 (-2.8A)
 1.03A 2b25A-4m8nE:
undetectable		 2b25A-4m8nE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 8 GLN A1114
PHE A 653
LEU A 657
PHE A 663
 None
 0.90A 2dyrC-4m8nA:
undetectable
2dyrJ-4m8nA:
undetectable		 2dyrC-4m8nA:
16.89
2dyrJ-4m8nA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 6 LEU A 675
ILE A 689
ILE A 644
ARG A 645
 None
 0.90A 2q8hA-4m8nA:
undetectable		 2q8hA-4m8nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4m8n RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens) 		5 / 12 TYR E   4
PHE E 158
GLY E  77
PRO E 110
ASP E  57
 None
None
None
None
MG  E 200 (-3.5A)
 1.31A 2zznA-4m8nE:
undetectable		 2zznA-4m8nE:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 6 GLN A1114
PHE A 653
LEU A 657
PHE A 663
 None
 1.02A 3ablP-4m8nA:
undetectable
3ablW-4m8nA:
undetectable		 3ablP-4m8nA:
16.89
3ablW-4m8nA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 7 GLN A1114
PHE A 653
LEU A 657
PHE A 663
 None
 0.96A 3asnC-4m8nA:
undetectable
3asnJ-4m8nA:
undetectable		 3asnC-4m8nA:
16.89
3asnJ-4m8nA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 11 LYS E  16
THR E  35
ASN E 116
GLY E  12
ARG A 711
 AF3  E 202 ( 3.1A)
MG  E 200 (-2.7A)
GDP  E 201 (-3.2A)
AF3  E 202 (-3.5A)
GDP  E 201 ( 2.9A)
 1.40A 3bexE-4m8nE:
undetectable
3bexF-4m8nE:
undetectable		 3bexE-4m8nE:
21.59
3bexF-4m8nE:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 12 VAL A 593
LEU A1023
PRO A 740
GLY A 738
LEU A 741
 None
 1.27A 3j6pB-4m8nA:
undetectable		 3j6pB-4m8nA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 9 TYR A1071
HIS A 991
VAL A1067
PHE A1034
VAL A1004
 None
 1.20A 3jwqA-4m8nA:
undetectable		 3jwqA-4m8nA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 9 PRO E  34
GLN E  63
ARG A 711
GLY E  12
VAL E  14
 AF3  E 202 ( 4.3A)
AF3  E 202 (-3.5A)
GDP  E 201 ( 2.9A)
AF3  E 202 (-3.5A)
GDP  E 201 (-4.3A)
 1.47A 4a3uA-4m8nE:
undetectable		 4a3uA-4m8nE:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 7 PRO E  34
GLN E  63
ARG A 711
GLY E  12
VAL E  14
 AF3  E 202 ( 4.3A)
AF3  E 202 (-3.5A)
GDP  E 201 ( 2.9A)
AF3  E 202 (-3.5A)
GDP  E 201 (-4.3A)
 1.48A 4a3uB-4m8nE:
undetectable		 4a3uB-4m8nE:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 9 VAL A 737
TYR A 730
ILE A 956
ILE A1006
PHE A 604
 None
 1.36A 4afgA-4m8nA:
0.0
4afgB-4m8nA:
0.0		 4afgA-4m8nA:
17.80
4afgB-4m8nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 9 VAL A 737
TYR A 730
ILE A 956
ILE A1006
PHE A 604
 None
 1.41A 4afgC-4m8nA:
0.0
4afgD-4m8nA:
0.0		 4afgC-4m8nA:
17.80
4afgD-4m8nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 9 VAL A 737
TYR A 730
ILE A 956
ILE A1006
PHE A 604
 None
 1.41A 4afgB-4m8nA:
0.0
4afgC-4m8nA:
0.0		 4afgB-4m8nA:
17.80
4afgC-4m8nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 7 SER A 940
GLN A 751
TYR A 766
ASP A 588
 None
 1.13A 4hxyB-4m8nA:
undetectable		 4hxyB-4m8nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 12 ASN A1005
LEU A1000
PHE E  64
GLY A1025
ASP A1024
 None
 1.08A 4n09A-4m8nA:
undetectable		 4n09A-4m8nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		3 / 3 ASN A1009
ASP A1024
ASP E  69
 None
 0.63A 4obwD-4m8nA:
undetectable		 4obwD-4m8nA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		4 / 5 LEU A 768
SER A 769
ASP A1024
ASP E  69
 None
 1.33A 4qtuD-4m8nA:
undetectable		 4qtuD-4m8nA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 6 GLN A1114
PHE A 653
LEU A 657
PHE A 663
 None
 0.83A 5b1bC-4m8nA:
undetectable
5b1bJ-4m8nA:
undetectable		 5b1bC-4m8nA:
16.89
5b1bJ-4m8nA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 12 ILE A 608
LEU A 720
PHE A 609
THR A 676
LEU A 733
 None
 1.05A 5byjA-4m8nA:
undetectable		 5byjA-4m8nA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 12 GLY E  15
GLY E  60
GLY E  13
VAL A1004
ILE E  36
 GDP  E 201 (-3.6A)
AF3  E 202 (-3.3A)
GDP  E 201 ( 3.1A)
None
None
 0.97A 5ehgC-4m8nE:
undetectable		 5ehgC-4m8nE:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		5 / 12 VAL A1067
ASP A 988
HIS A 991
PHE A 972
ARG A 711
 None
None
None
None
GDP  E 201 ( 2.9A)
 1.34A 5hnzB-4m8nA:
undetectable		 5hnzB-4m8nA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 4 SER A1049
THR A1041
ASP A 988
ASP A1036
 None
 1.43A 5vimA-4m8nA:
undetectable		 5vimA-4m8nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		5 / 12 GLY E  15
GLY E  60
GLY E  13
VAL A1004
ILE E  36
 GDP  E 201 (-3.6A)
AF3  E 202 (-3.3A)
GDP  E 201 ( 3.1A)
None
None
 0.95A 5vimB-4m8nE:
undetectable		 5vimB-4m8nE:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 4 SER A1049
THR A1041
ASP A 988
ASP A1036
 None
 1.44A 5vimB-4m8nA:
undetectable		 5vimB-4m8nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4m8n PLEXINC1
INTRACELLULAR REGION
(Danio
rerio) 		4 / 6 GLN A1114
PHE A 653
LEU A 657
PHE A 663
 None
 1.12A 5z86C-4m8nA:
undetectable
5z86J-4m8nA:
undetectable		 5z86C-4m8nA:
16.89
5z86J-4m8nA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B
(Danio
rerio;
Homo
sapiens) 		4 / 6 PHE E  28
ALA E  18
THR E  85
ASN A 705
 GDP  E 201 (-4.7A)
GDP  E 201 (-3.2A)
None
None
 0.96A 6f88A-4m8nE:
undetectable		 6f88A-4m8nE:
16.84