SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 8 SER A 439
VAL A 176
SER A 175
ASP A 280
 None
 1.06A 1hwiB-4m8rA:
undetectable		 1hwiB-4m8rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 8 SER A 439
VAL A 176
SER A 175
ASP A 280
 None
 1.03A 1hwkA-4m8rA:
undetectable		 1hwkA-4m8rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 8 SER A 439
VAL A 176
SER A 175
ASP A 280
 None
 1.03A 1hwkC-4m8rA:
undetectable		 1hwkC-4m8rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 8 SER A 439
VAL A 176
SER A 175
ASP A 280
 None
 1.05A 1hwkD-4m8rA:
undetectable		 1hwkD-4m8rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 6 TYR A 183
TRP A 165
TYR A 141
ILE A 150
 None
 1.44A 2pgzD-4m8rA:
undetectable
2pgzE-4m8rA:
undetectable		 2pgzD-4m8rA:
20.71
2pgzE-4m8rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 7 GLY A 331
PHE A 330
PHE A 364
PHE A 382
 None
 1.01A 3ko0D-4m8rA:
undetectable
3ko0E-4m8rA:
undetectable		 3ko0D-4m8rA:
16.58
3ko0E-4m8rA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 8 GLY A 331
PHE A 330
PHE A 364
PHE A 382
 None
 0.81A 3ko0O-4m8rA:
undetectable
3ko0Q-4m8rA:
undetectable		 3ko0O-4m8rA:
16.58
3ko0Q-4m8rA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ILE A 100
PHE A  67
ASP A  68
GLU A 112
 None
 1.17A 3kp6A-4m8rA:
undetectable
3kp6B-4m8rA:
undetectable		 3kp6A-4m8rA:
16.08
3kp6B-4m8rA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 ILE A  54
MET A 102
ARG A 101
 None
 0.95A 4lnwA-4m8rA:
undetectable		 4lnwA-4m8rA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 ILE A  54
MET A 102
ARG A 101
 None
 0.94A 4lnxA-4m8rA:
undetectable		 4lnxA-4m8rA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.38A 4oltA-4m8rA:
undetectable		 4oltA-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.44A 4oltA-4m8rA:
undetectable		 4oltA-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.36A 4oltB-4m8rA:
undetectable		 4oltB-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.43A 4oltB-4m8rA:
undetectable		 4oltB-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.39A 4qwpA-4m8rA:
undetectable		 4qwpA-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.46A 4qwpA-4m8rA:
undetectable		 4qwpA-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.42A 4qwpB-4m8rA:
undetectable		 4qwpB-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ARG A 101
THR A 204
ASP A 201
TYR A 252
 None
None
None
EDO  A 505 (-3.3A)
 1.50A 4qwpB-4m8rA:
undetectable		 4qwpB-4m8rA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 8 GLN A 287
TYR A 329
SER A 224
ASN A 289
 None
EDO  A 506 (-4.4A)
None
None
 1.04A 4wryA-4m8rA:
undetectable		 4wryA-4m8rA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 ALA A 229
LEU A 240
GLY A 283
PRO A 282
ALA A 219
 None
None
None
EDO  A 506 (-4.4A)
None
 1.06A 4ypmA-4m8rA:
undetectable		 4ypmA-4m8rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZD_A_RBFA201_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 4 ALA A 153
VAL A 440
TRP A 442
ASP A 418
 None
 1.36A 4zzdA-4m8rA:
0.0		 4zzdA-4m8rA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 LEU A 378
GLY A 319
GLU A 318
PRO A 305
GLY A 301
 None
 1.05A 5f9zA-4m8rA:
undetectable		 5f9zA-4m8rA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 ALA A  88
GLY A  84
GLY A 125
PHE A  69
VAL A 111
 None
 0.95A 5w4zA-4m8rA:
undetectable		 5w4zA-4m8rA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 ALA A  88
GLY A  84
GLY A 125
PHE A  69
VAL A 111
 None
 0.99A 5w4zB-4m8rA:
undetectable		 5w4zB-4m8rA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 6 TYR A 429
VAL A 440
VAL A 405
THR A 404
 None
 1.01A 6f32B-4m8rA:
undetectable		 6f32B-4m8rA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4m8r HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 ARG A 117
PHE A 114
PHE A  59
 None
 0.99A 6nknC-4m8rA:
undetectable
6nknJ-4m8rA:
undetectable		 6nknC-4m8rA:
18.18
6nknJ-4m8rA:
10.45