SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 9 ASP A  26
GLY A  19
ALA A 216
GLN A 217
THR A  27
 None
 1.25A 2dtjA-4m8sA:
undetectable
2dtjB-4m8sA:
undetectable		 2dtjA-4m8sA:
24.42
2dtjB-4m8sA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 11 LEU A 115
THR A 141
MET A 169
LEU A 246
VAL A 143
 None
 1.47A 2n27A-4m8sA:
undetectable		 2n27A-4m8sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 12 ILE A  24
ALA A  23
GLY A  19
ILE A 219
GLY A  15
 None
 0.81A 2qe6A-4m8sA:
6.3		 2qe6A-4m8sA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 12 ILE A  24
ALA A  23
GLY A  19
ILE A 219
GLY A  15
 None
 0.84A 2qe6B-4m8sA:
6.0		 2qe6B-4m8sA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		3 / 3 PHE A 225
SER A 228
GLN A 230
 None
 0.88A 3smtA-4m8sA:
undetectable		 3smtA-4m8sA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 12 GLY A  21
ASP A  26
ILE A  10
ALA A  29
ALA A  33
 None
 1.07A 3sueA-4m8sA:
undetectable		 3sueA-4m8sA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 11 ILE A  24
ILE A  20
GLY A  19
VAL A 241
GLY A 214
 None
 1.04A 4ac9B-4m8sA:
6.8
4ac9C-4m8sA:
6.5		 4ac9B-4m8sA:
21.18
4ac9C-4m8sA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 10 ALA A 227
ASP A 229
LEU A  28
ALA A  31
ALA A  11
 None
 1.12A 4zbrA-4m8sA:
undetectable		 4zbrA-4m8sA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 12 ALA A  16
ALA A  11
LYS A  34
ALA A  29
ILE A  86
 None
 1.22A 5eypB-4m8sA:
6.4		 5eypB-4m8sA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 12 ILE A 178
ARG A 136
GLU A 172
ARG A 171
GLY A 174
 None
 1.21A 5k7uA-4m8sA:
2.0		 5k7uA-4m8sA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		4 / 4 GLN A 230
THR A   3
LEU A  28
LEU A 224
 None
 1.23A 5m5kB-4m8sA:
8.3		 5m5kB-4m8sA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		5 / 12 VAL A  35
LEU A  52
VAL A  13
GLY A  21
ILE A  24
 None
 1.05A 5vopA-4m8sA:
2.7		 5vopA-4m8sA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Neisseria
meningitidis) 		4 / 6 ARG A  18
ARG A  51
ALA A  47
ALA A  16
 None
 1.18A 6ma6A-4m8sA:
undetectable		 6ma6A-4m8sA:
14.04