SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 10 PHE A  53
VAL A  52
VAL A  99
ILE A  84
PRO A  15
 None
 1.47A 13gsA-4m8uA:
undetectable		 13gsA-4m8uA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 9 PHE A  53
VAL A  52
VAL A  99
ILE A  84
PRO A  15
 None
 1.47A 13gsB-4m8uA:
undetectable		 13gsB-4m8uA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 TRP A 323
VAL A   9
TRP A   5
 None
 1.23A 1c4dA-4m8uA:
undetectable
1c4dB-4m8uA:
undetectable		 1c4dA-4m8uA:
3.25
1c4dB-4m8uA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 TRP A 323
VAL A  10
TRP A   5
 None
 1.10A 1c4dA-4m8uA:
undetectable
1c4dB-4m8uA:
undetectable		 1c4dA-4m8uA:
3.25
1c4dB-4m8uA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		6 / 12 TYR A  62
ASP A 199
ALA A 200
HIS A 331
ASP A 332
ARG A 422
 TRS  A 601 (-3.6A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
None
GOL  A 602 (-2.8A)
None
 0.73A 1dedA-4m8uA:
27.0		 1dedA-4m8uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		8 / 12 TYR A  62
ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ARG A 422
 TRS  A 601 (-3.6A)
TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
None
 0.78A 1dedB-4m8uA:
26.4		 1dedB-4m8uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 5 ARG A 422
ALA A 421
ASP A 387
GLY A 417
 None
 1.20A 1e7bA-4m8uA:
undetectable		 1e7bA-4m8uA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 6 TYR A  19
GLY A  31
ASP A  28
GLY A  23
 None
None
CA  A 603 (-3.2A)
None
 0.68A 1eswA-4m8uA:
17.9		 1eswA-4m8uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 ALA A 200
VAL A 100
TRP A 172
 TRS  A 601 ( 4.0A)
None
None
 0.81A 1kqeA-4m8uA:
undetectable
1kqeE-4m8uA:
undetectable		 1kqeA-4m8uA:
6.63
1kqeE-4m8uA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 ALA A 200
VAL A 100
TRP A 172
 TRS  A 601 ( 4.0A)
None
None
 0.80A 1kqeB-4m8uA:
undetectable
1kqeD-4m8uA:
undetectable		 1kqeB-4m8uA:
6.63
1kqeD-4m8uA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 TRP A 172
ALA A 200
VAL A 100
 None
TRS  A 601 ( 4.0A)
None
 0.81A 1kqeB-4m8uA:
undetectable
1kqeD-4m8uA:
undetectable		 1kqeB-4m8uA:
6.63
1kqeD-4m8uA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 TRP A 172
ALA A 200
VAL A 100
 None
TRS  A 601 ( 4.0A)
None
 0.80A 1kqeA-4m8uA:
undetectable
1kqeE-4m8uA:
undetectable		 1kqeA-4m8uA:
6.63
1kqeE-4m8uA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 TRP A 340
HIS A 283
MET A 284
 None
GOL  A 606 (-3.8A)
None
 1.17A 1l5qB-4m8uA:
undetectable		 1l5qB-4m8uA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 TYR A  62
HIS A 102
ARG A 197
ASP A 199
GLU A 255
HIS A 331
ASP A 332
 TRS  A 601 (-3.6A)
TRS  A 601 (-4.0A)
TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
 0.39A 1mxdA-4m8uA:
22.9		 1mxdA-4m8uA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 TYR A  62
HIS A 102
PHE A 163
ARG A 197
ASP A 199
HIS A 331
ASP A 332
 TRS  A 601 (-3.6A)
TRS  A 601 (-4.0A)
TRS  A 601 ( 3.9A)
TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
None
GOL  A 602 (-2.8A)
 1.04A 1mxdA-4m8uA:
22.9		 1mxdA-4m8uA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 ASN A 512
ALA A 353
ASN A 537
 None
 0.83A 1n4fA-4m8uA:
undetectable		 1n4fA-4m8uA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 9 VAL A 336
LEU A 470
TYR A 467
VAL A 357
ALA A 353
 None
 1.17A 1pxxB-4m8uA:
undetectable		 1pxxB-4m8uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 10 VAL A 336
LEU A 470
TYR A 467
VAL A 357
ALA A 353
 None
 1.18A 1pxxD-4m8uA:
undetectable		 1pxxD-4m8uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 6 LEU A 488
GLU A 490
THR A 316
TYR A 485
 None
 1.12A 1qvuA-4m8uA:
undetectable		 1qvuA-4m8uA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 6 ASP A 332
ARG A 418
ASP A 419
ASP A  59
 GOL  A 602 (-2.8A)
TRS  A 601 ( 3.3A)
None
TRS  A 601 (-2.8A)
 1.25A 2j2pE-4m8uA:
undetectable
2j2pF-4m8uA:
undetectable		 2j2pE-4m8uA:
16.61
2j2pF-4m8uA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 6 ASP A 387
TYR A 385
TYR A 394
LEU A 397
 None
None
None
GOL  A 605 (-4.7A)
 1.19A 2w98A-4m8uA:
undetectable
2w98B-4m8uA:
undetectable		 2w98A-4m8uA:
20.82
2w98B-4m8uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
 0.68A 3aicA-4m8uA:
5.0		 3aicA-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		6 / 12 ARG A 197
ASP A 199
GLU A 255
HIS A 331
ASP A 332
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 ( 4.3A)
 0.85A 3aicA-4m8uA:
5.0		 3aicA-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 LEU A  29
TRP A 441
TYR A  71
 None
 0.94A 3aicA-4m8uA:
5.0		 3aicA-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
 0.71A 3aicB-4m8uA:
4.0		 3aicB-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		6 / 12 ARG A 197
ASP A 199
GLU A 255
HIS A 331
ASP A 332
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 ( 4.3A)
 0.82A 3aicB-4m8uA:
4.0		 3aicB-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 LEU A  29
TRP A 441
TYR A  71
 None
 0.98A 3aicB-4m8uA:
4.2		 3aicB-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		8 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
TYR A  62
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
TRS  A 601 (-3.6A)
 0.68A 3aicC-4m8uA:
3.8		 3aicC-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		6 / 12 ARG A 197
GLU A 255
HIS A 331
ASP A 332
TYR A  62
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-3.6A)
TRS  A 601 ( 4.3A)
 0.89A 3aicC-4m8uA:
3.8		 3aicC-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
 0.74A 3aicD-4m8uA:
7.7		 3aicD-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 ARG A 197
GLU A 255
HIS A 331
ASP A 332
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 ( 4.3A)
 0.88A 3aicD-4m8uA:
7.7		 3aicD-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
 0.74A 3aicE-4m8uA:
7.5		 3aicE-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 ARG A 197
GLU A 255
HIS A 331
ASP A 332
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 ( 4.3A)
 0.84A 3aicE-4m8uA:
7.5		 3aicE-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 LEU A  29
TRP A 441
TYR A  71
 None
 0.96A 3aicE-4m8uA:
7.5		 3aicE-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
 0.73A 3aicF-4m8uA:
4.7		 3aicF-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		6 / 12 ARG A 197
ASP A 199
GLU A 255
HIS A 331
ASP A 332
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 ( 4.3A)
 0.83A 3aicF-4m8uA:
4.7		 3aicF-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 LEU A  29
TRP A 441
TYR A  71
 None
 0.94A 3aicF-4m8uA:
4.1		 3aicF-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
 0.69A 3aicG-4m8uA:
4.7		 3aicG-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		6 / 12 ARG A 197
ASP A 199
GLU A 255
HIS A 331
ASP A 332
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 ( 4.3A)
 0.83A 3aicG-4m8uA:
4.7		 3aicG-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 LEU A  29
TRP A 441
TYR A  71
 None
 0.94A 3aicG-4m8uA:
3.9		 3aicG-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		7 / 12 ARG A 197
ASP A 199
ALA A 200
GLU A 255
HIS A 331
ASP A 332
ASP A  59
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 4.0A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 (-2.8A)
 0.73A 3aicH-4m8uA:
7.5		 3aicH-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 ARG A 197
GLU A 255
HIS A 331
ASP A 332
GLN A 167
 TRS  A 601 ( 4.8A)
TRS  A 601 ( 2.7A)
None
GOL  A 602 (-2.8A)
TRS  A 601 ( 4.3A)
 0.85A 3aicH-4m8uA:
7.5		 3aicH-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		3 / 3 LEU A  29
TRP A 441
TYR A  71
 None
 0.94A 3aicH-4m8uA:
5.3		 3aicH-4m8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KDM_H_TESH226_1
(IMMUNOGLOBULIN HEAVY
CHAIN
IMMUNOGLOBULIN LIGHT
CHAIN)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 9 SER A 147
TRP A 149
ALA A 148
TYR A 162
TYR A 213
 None
 1.37A 3kdmH-4m8uA:
0.0
3kdmL-4m8uA:
0.0		 3kdmH-4m8uA:
15.28
3kdmL-4m8uA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 6 VAL A 321
ASN A 324
GLU A 262
ILE A 261
 None
GOL  A 606 (-3.0A)
None
None
 1.06A 3q5sA-4m8uA:
undetectable		 3q5sA-4m8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ARG A 339
TYR A 327
GLU A 329
HIS A 283
 None
GOL  A 606 (-4.8A)
None
GOL  A 606 (-3.8A)
 1.34A 3zmdA-4m8uA:
undetectable
3zmdB-4m8uA:
undetectable		 3zmdA-4m8uA:
12.94
3zmdB-4m8uA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 387
ASP A  59
GLU A 389
ASP A 199
 None
TRS  A 601 (-2.8A)
GOL  A 602 (-3.0A)
TRS  A 601 (-2.7A)
 1.15A 4gkhC-4m8uA:
undetectable
4gkhK-4m8uA:
3.9		 4gkhC-4m8uA:
18.38
4gkhK-4m8uA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 387
ASP A 285
GLU A 389
GLU A 255
 None
None
GOL  A 602 (-3.0A)
TRS  A 601 ( 2.7A)
 1.11A 4gkhC-4m8uA:
undetectable
4gkhK-4m8uA:
3.9		 4gkhC-4m8uA:
18.38
4gkhK-4m8uA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 387
ASP A  59
GLU A 389
ASP A 199
 None
TRS  A 601 (-2.8A)
GOL  A 602 (-3.0A)
TRS  A 601 (-2.7A)
 1.12A 4gkiE-4m8uA:
3.8
4gkiG-4m8uA:
4.2		 4gkiE-4m8uA:
18.38
4gkiG-4m8uA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 387
ASP A 285
GLU A 389
GLU A 255
 None
None
GOL  A 602 (-3.0A)
TRS  A 601 ( 2.7A)
 1.12A 4gkiE-4m8uA:
3.8
4gkiG-4m8uA:
4.2		 4gkiE-4m8uA:
18.38
4gkiG-4m8uA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 ILE A 481
LEU A 307
LEU A 513
TYR A 498
LEU A 326
 None
None
None
None
GOL  A 606 (-4.8A)
 1.30A 4j03A-4m8uA:
3.0		 4j03A-4m8uA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 5 ARG A 335
ARG A 418
GLY A 417
GLU A 389
 None
TRS  A 601 ( 3.3A)
None
GOL  A 602 (-3.0A)
 1.17A 4z3oA-4m8uA:
undetectable
4z3oB-4m8uA:
undetectable		 4z3oA-4m8uA:
21.40
4z3oB-4m8uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 5 ARG A 418
GLY A 417
GLU A 389
ARG A 335
 TRS  A 601 ( 3.3A)
None
GOL  A 602 (-3.0A)
None
 1.18A 5cdqR-4m8uA:
undetectable
5cdqS-4m8uA:
undetectable
5cdqT-4m8uA:
undetectable		 5cdqR-4m8uA:
22.97
5cdqS-4m8uA:
17.39
5cdqT-4m8uA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		6 / 12 ARG A 197
ASP A 199
GLU A 255
HIS A 283
HIS A 331
ASP A 332
 TRS  A 601 ( 4.8A)
TRS  A 601 (-2.7A)
TRS  A 601 ( 2.7A)
GOL  A 606 (-3.8A)
None
GOL  A 602 (-2.8A)
 0.88A 5csyB-4m8uA:
17.3		 5csyB-4m8uA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ILE A 204
PHE A 236
GLN A 238
GLU A 235
 None
 1.10A 5dqyA-4m8uA:
undetectable		 5dqyA-4m8uA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 GLY A 230
ASN A 229
ALA A 200
ASN A 101
ASN A 257
 None
None
TRS  A 601 ( 4.0A)
None
None
 1.40A 5kc4A-4m8uA:
undetectable		 5kc4A-4m8uA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 7 GLY A 195
ASP A 249
HIS A  88
ASP A 194
 None
 1.09A 5no9D-4m8uA:
undetectable		 5no9D-4m8uA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 ASP A 332
ALA A 200
PHE A 144
PHE A 163
LEU A 388
 GOL  A 602 (-2.8A)
TRS  A 601 ( 4.0A)
TRS  A 601 (-4.8A)
TRS  A 601 ( 3.9A)
None
 1.24A 5tudD-4m8uA:
undetectable		 5tudD-4m8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 5 ASN A 330
GLN A 333
ASP A 332
ARG A 422
 None
None
GOL  A 602 (-2.8A)
None
 1.50A 5w4zA-4m8uA:
8.5		 5w4zA-4m8uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 TYR A  62
HIS A 102
ASP A 199
HIS A 331
ASP A 332
 TRS  A 601 (-3.6A)
TRS  A 601 (-4.0A)
TRS  A 601 (-2.7A)
None
GOL  A 602 (-2.8A)
 0.51A 6ag0A-4m8uA:
19.3		 6ag0A-4m8uA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 6 GLN A  12
VAL A 253
MET A  80
ARG A  90
 None
 1.25A 6brdB-4m8uA:
undetectable		 6brdB-4m8uA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 TRP A   5
TYR A 482
GLU A   7
TRP A 323
 None
 1.12A 6c71B-4m8uA:
undetectable		 6c71B-4m8uA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 11 VAL A 357
ALA A 555
LEU A 304
ASP A 492
ALA A 353
 None
 1.39A 6dk1C-4m8uA:
undetectable		 6dk1C-4m8uA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 194
ILE A  84
ASN A  77
TRP A 188
 None
 1.20A 6hisA-4m8uA:
undetectable
6hisB-4m8uA:
undetectable		 6hisA-4m8uA:
10.31
6hisB-4m8uA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 194
ILE A  84
ASN A  77
TRP A 188
 None
 1.19A 6hisB-4m8uA:
undetectable
6hisC-4m8uA:
undetectable		 6hisB-4m8uA:
10.31
6hisC-4m8uA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 194
ILE A  84
ASN A  77
TRP A 188
 None
 1.20A 6hisC-4m8uA:
undetectable
6hisD-4m8uA:
undetectable		 6hisC-4m8uA:
10.31
6hisD-4m8uA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASP A 194
ILE A  84
ASN A  77
TRP A 188
 None
 1.19A 6hisD-4m8uA:
undetectable
6hisE-4m8uA:
undetectable		 6hisD-4m8uA:
10.31
6hisE-4m8uA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		4 / 8 ASN A  77
TRP A 188
ASP A 194
ILE A  84
 None
 1.20A 6hisA-4m8uA:
undetectable
6hisE-4m8uA:
undetectable		 6hisA-4m8uA:
10.31
6hisE-4m8uA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4m8u OLIGO-1,6-GLUCOSIDAS
E 1
(Bacillus
subtilis) 		5 / 12 VAL A 177
VAL A 181
ASP A 105
ASN A 101
TYR A  67
 None
 1.26A 6mxtA-4m8uA:
undetectable		 6mxtA-4m8uA:
20.60