SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 296
SER A  62
TYR A  63
 None
 0.63A 1x70A-4m9aA:
undetectable		 1x70A-4m9aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 11 ILE A 244
ALA A 316
ALA A 319
GLN A 318
LEU A 298
 None
 1.10A 2aclE-4m9aA:
undetectable		 2aclE-4m9aA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 152
GLY A 192
ILE A 194
ALA A 166
VAL A 168
 None
 0.93A 2b7zB-4m9aA:
undetectable		 2b7zB-4m9aA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 ALA A  77
ILE A 253
ILE A 204
ASP A 355
 None
 1.03A 2h4jA-4m9aA:
undetectable		 2h4jA-4m9aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A  76
TRP A  31
LEU A  37
GLN A  44
PHE A  19
 None
 1.40A 2no0A-4m9aA:
undetectable		 2no0A-4m9aA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 167
LEU A 150
CYH A 217
THR A 190
LEU A 165
 None
 1.19A 2qo5A-4m9aA:
undetectable		 2qo5A-4m9aA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 TYR A  69
ALA A  70
LEU A  73
THR A 359
 None
 0.78A 3b6hB-4m9aA:
1.3		 3b6hB-4m9aA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 TYR A  69
TYR A  66
SER A  62
ILE A  12
 None
 1.07A 3jz0B-4m9aA:
3.4		 3jz0B-4m9aA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 LEU A 344
ASP A 346
TYR A 347
 None
 0.65A 4qc6B-4m9aA:
undetectable		 4qc6B-4m9aA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 THR A 126
LEU A 214
ALA A 122
PHE A 156
THR A 190
 None
 1.42A 5ewjC-4m9aA:
undetectable
5ewjD-4m9aA:
undetectable		 5ewjC-4m9aA:
20.33
5ewjD-4m9aA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 ALA A  25
CYH A  20
ALA A  81
ALA A  78
ASP A 259
 None
 1.20A 5lf3H-4m9aA:
undetectable
5lf3I-4m9aA:
undetectable		 5lf3H-4m9aA:
18.80
5lf3I-4m9aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.38A 5n0rA-4m9aA:
undetectable		 5n0rA-4m9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.40A 5n0sA-4m9aA:
undetectable		 5n0sA-4m9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.40A 5n0tA-4m9aA:
undetectable		 5n0tA-4m9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.39A 5n0wA-4m9aA:
undetectable		 5n0wA-4m9aA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.38A 5n0wB-4m9aA:
undetectable		 5n0wB-4m9aA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.36A 5n0xA-4m9aA:
undetectable		 5n0xA-4m9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 SER A 324
ALA A 323
GLN A 318
THR A 299
 None
 1.37A 5n4iA-4m9aA:
undetectable		 5n4iA-4m9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4m9a ACYL-COA
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A  24
ALA A  78
GLU A 363
THR A  85
VAL A  89
 None
 1.16A 5x6yA-4m9aA:
undetectable		 5x6yA-4m9aA:
18.45