SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 12 PHE A 611
VAL A 606
VAL A 647
ALA A 581
ILE A 654
 None
 1.00A 1epbA-4m9pA:
undetectable		 1epbA-4m9pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 12 GLY A 585
VAL A 645
ALA A 661
ASP A 596
ALA A 595
 None
 1.41A 2avdB-4m9pA:
undetectable		 2avdB-4m9pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4m9p FILAMIN-A
(Homo
sapiens) 		4 / 5 VAL A 599
VAL A 598
GLN A 710
ARG A 708
 None
 1.36A 3bjwB-4m9pA:
undetectable		 3bjwB-4m9pA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4m9p FILAMIN-A
(Homo
sapiens) 		4 / 8 PHE A 597
GLY A 585
ILE A 621
CYH A 623
 None
 0.89A 3ko0O-4m9pA:
undetectable
3ko0Q-4m9pA:
undetectable		 3ko0O-4m9pA:
16.85
3ko0Q-4m9pA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 12 ARG A 664
GLY A 702
GLY A 729
GLY A 750
LEU A 707
 None
 1.18A 3ku1G-4m9pA:
undetectable		 3ku1G-4m9pA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 11 VAL A 517
LEU A 515
ILE A 561
ALA A 485
LEU A 490
 None
 1.18A 3n8yA-4m9pA:
undetectable		 3n8yA-4m9pA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 11 VAL A 709
LEU A 707
ILE A 754
ALA A 677
LEU A 682
 None
 1.12A 3n8yA-4m9pA:
undetectable		 3n8yA-4m9pA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 11 GLY A 583
ASP A 596
ALA A 595
GLY A 585
VAL A 645
 None
 1.05A 4c5lA-4m9pA:
undetectable		 4c5lA-4m9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 9 GLY A 583
ASP A 596
ALA A 595
GLY A 585
VAL A 645
 None
 1.05A 4c5lB-4m9pA:
undetectable		 4c5lB-4m9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 10 GLY A 583
ASP A 596
ALA A 595
GLY A 585
VAL A 645
 None
 1.13A 4c5lC-4m9pA:
undetectable		 4c5lC-4m9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 10 GLY A 583
ASP A 596
ALA A 595
GLY A 585
VAL A 645
 None
 1.12A 4c5lD-4m9pA:
undetectable		 4c5lD-4m9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 10 GLY A 583
ASP A 596
ALA A 595
GLY A 585
VAL A 645
 None
 1.07A 4c5nB-4m9pA:
undetectable		 4c5nB-4m9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 10 GLY A 583
ASP A 596
ALA A 595
GLY A 585
VAL A 645
 None
 1.15A 4c5nD-4m9pA:
undetectable		 4c5nD-4m9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 12 GLU A 587
GLY A 588
ALA A 595
ALA A 661
TYR A 635
 None
 1.38A 4pclB-4m9pA:
undetectable		 4pclB-4m9pA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 12 ILE A 663
GLY A 588
ARG A 664
MET A 660
ALA A 644
 None
 1.16A 5h5fA-4m9pA:
undetectable		 5h5fA-4m9pA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4m9p FILAMIN-A
(Homo
sapiens) 		5 / 9 ALA A 595
SER A 594
GLY A 589
SER A 748
GLY A 750
 None
 1.14A 6bklE-4m9pA:
undetectable
6bklF-4m9pA:
undetectable
6bklG-4m9pA:
undetectable
6bklH-4m9pA:
undetectable		 6bklE-4m9pA:
7.21
6bklF-4m9pA:
7.21
6bklG-4m9pA:
7.21
6bklH-4m9pA:
7.21