SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		3 / 3 ALA A 392
VAL A 413
TRP A 410
 None
 0.90A 1bdwA-4m9xA:
undetectable
1bdwB-4m9xA:
undetectable		 1bdwA-4m9xA:
9.52
1bdwB-4m9xA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 8 LEU A 266
ARG A 267
LEU A 211
SER A 186
 None
 1.09A 1hk3A-4m9xA:
undetectable		 1hk3A-4m9xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		3 / 3 ASP A 206
LEU A 209
HIS A 225
 None
 0.66A 1qknA-4m9xA:
undetectable		 1qknA-4m9xA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 8 LEU A 217
ARG A 242
VAL A 188
GLY A 122
 None
 0.83A 2qd5A-4m9xA:
2.9		 2qd5A-4m9xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		3 / 3 ARG A 358
GLY A 359
SER A 542
 None
 0.64A 2xctB-4m9xA:
4.6		 2xctB-4m9xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 6 ALA A  84
LEU A  83
ALA A  13
THR A  12
 None
 0.81A 3b6hA-4m9xA:
undetectable		 3b6hA-4m9xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 6 ALA A  84
LEU A  83
ALA A  13
THR A  12
 None
 0.80A 3b6hB-4m9xA:
undetectable		 3b6hB-4m9xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 7 VAL A 248
ILE A 180
GLY A 181
ARG A 102
 None
 0.78A 3bjwB-4m9xA:
undetectable		 3bjwB-4m9xA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 7 VAL A 248
ILE A 180
GLY A 181
ARG A 102
 None
 0.72A 3bjwH-4m9xA:
undetectable		 3bjwH-4m9xA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		3 / 3 CYH A 268
PHE A 247
PHE A 249
 None
 1.02A 3cr5X-4m9xA:
undetectable		 3cr5X-4m9xA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 8 ALA A  55
ILE A  54
ASN A  56
PRO A  23
 None
 0.97A 3fxrA-4m9xA:
1.9		 3fxrA-4m9xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 5 GLU A 356
LEU A 355
HIS A 466
GLY A 359
 None
 1.18A 3pp1A-4m9xA:
undetectable		 3pp1A-4m9xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 5 THR A 367
PRO A 368
PHE A 301
TYR A 305
 ATP  A 602 (-4.4A)
ATP  A 602 (-3.9A)
ATP  A 602 (-4.5A)
None
 1.31A 4mf6A-4m9xA:
undetectable		 4mf6A-4m9xA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 5 ASN A 329
ALA A 331
GLY A 162
ASP A 138
 None
ATP  A 602 (-3.7A)
ATP  A 602 (-3.6A)
None
 0.99A 4n48A-4m9xA:
undetectable		 4n48A-4m9xA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		3 / 3 LYS A 165
ARG A 133
HIS A 136
 ATP  A 602 (-2.6A)
None
None
 1.18A 4zbrA-4m9xA:
undetectable		 4zbrA-4m9xA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		5 / 12 VAL A 403
ASP A 404
LEU A 484
HIS A 536
LEU A 480
 None
 1.22A 5hnyB-4m9xA:
undetectable		 5hnyB-4m9xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		5 / 12 ILE A 323
LEU A 302
GLU A 294
HIS A 136
GLY A 328
 None
 1.36A 5k7uA-4m9xA:
undetectable		 5k7uA-4m9xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		4 / 8 THR A 332
PRO A 330
VAL A 290
GLY A 159
 None
ATP  A 602 (-4.6A)
None
None
 1.03A 5nzyA-4m9xA:
3.2		 5nzyA-4m9xA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		3 / 3 LEU A 239
LEU A 211
ARG A 242
 None
 0.62A 6fgcA-4m9xA:
1.9		 6fgcA-4m9xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4m9x CELL DEATH PROTEIN 4
(Caenorhabditis
elegans) 		3 / 3 LEU A 239
LEU A 211
ARG A 242
 None
 0.61A 6fgdA-4m9xA:
2.0		 6fgdA-4m9xA:
21.15