SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ma3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4ma3 C2095 LIGHT CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 8 TYR L  37
TYR L  50
LEU L  90
SER L  92
 None
 0.54A 1i7zA-4ma3L:
27.5		 1i7zA-4ma3L:
76.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4ma3 C2095 LIGHT CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 7 LEU L 141
THR L 178
SER L 168
THR L 170
 None
 0.72A 1ictD-4ma3L:
undetectable		 1ictD-4ma3L:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ma3 C2095 LIGHT CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 5 LEU L 185
GLY L 134
PRO L 126
VAL L 138
 None
 0.86A 2aojA-4ma3L:
undetectable		 2aojA-4ma3L:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4ma3 C2095 LIGHT CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		3 / 3 SER L  11
ALA L  13
VAL L  14
 None
 0.62A 4o2bA-4ma3L:
undetectable		 4o2bA-4ma3L:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4ma3 C2095 LIGHT CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus) 		4 / 5 VAL L  18
ILE L  20
VAL L 109
THR L 107
 None
 0.72A 4xdtA-4ma3L:
undetectable		 4xdtA-4ma3L:
20.46