SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ma5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
5 / 12 GLU A  69
ILE A 187
GLN A 279
ARG A 263
GLU A 247
None
None
None
None
ANP  A 401 ( 2.8A)
1.39A 1ki7B-4ma5A:
undetectable
1ki7B-4ma5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 8 LYS A 138
LEU A 137
GLN A 149
LEU A 124
ANP  A 401 ( 2.8A)
None
ANP  A 401 ( 4.5A)
None
0.94A 1v54P-4ma5A:
undetectable
1v54W-4ma5A:
undetectable
1v54P-4ma5A:
22.16
1v54W-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.91A 1v55C-4ma5A:
undetectable
1v55J-4ma5A:
undetectable
1v55C-4ma5A:
22.16
1v55J-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LYS A 138
LEU A 137
GLN A 149
LEU A 124
ANP  A 401 ( 2.8A)
None
ANP  A 401 ( 4.5A)
None
0.94A 1v55C-4ma5A:
undetectable
1v55J-4ma5A:
undetectable
1v55C-4ma5A:
22.16
1v55J-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 5 LEU A 315
LEU A 318
LEU A 341
CYH A 305
None
0.83A 2ab2B-4ma5A:
undetectable
2ab2B-4ma5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
5 / 11 ILE A 230
HIS A 108
TYR A 240
GLY A 194
LEU A 244
None
1.20A 2azyA-4ma5A:
undetectable
2azyA-4ma5A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.94A 2dysP-4ma5A:
undetectable
2dysW-4ma5A:
undetectable
2dysP-4ma5A:
22.16
2dysW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LYS A 138
LEU A 137
GLN A 149
LEU A 124
ANP  A 401 ( 2.8A)
None
ANP  A 401 ( 4.5A)
None
0.93A 2dysP-4ma5A:
undetectable
2dysW-4ma5A:
undetectable
2dysP-4ma5A:
22.16
2dysW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.93A 2eijC-4ma5A:
undetectable
2eijJ-4ma5A:
undetectable
2eijC-4ma5A:
22.16
2eijJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LYS A 138
LEU A 137
GLN A 149
LEU A 124
ANP  A 401 ( 2.8A)
None
ANP  A 401 ( 4.5A)
None
0.98A 2eijC-4ma5A:
undetectable
2eijJ-4ma5A:
undetectable
2eijC-4ma5A:
22.16
2eijJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.89A 2eikC-4ma5A:
undetectable
2eikJ-4ma5A:
undetectable
2eikC-4ma5A:
22.16
2eikJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 8 LYS A 138
LEU A 137
GLN A 149
LEU A 124
ANP  A 401 ( 2.8A)
None
ANP  A 401 ( 4.5A)
None
0.91A 2eikP-4ma5A:
undetectable
2eikW-4ma5A:
undetectable
2eikP-4ma5A:
22.16
2eikW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.85A 2eimC-4ma5A:
undetectable
2eimJ-4ma5A:
undetectable
2eimC-4ma5A:
22.16
2eimJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LYS A 138
LEU A 137
GLN A 149
LEU A 124
ANP  A 401 ( 2.8A)
None
ANP  A 401 ( 4.5A)
None
0.95A 2eimC-4ma5A:
undetectable
2eimJ-4ma5A:
undetectable
2eimC-4ma5A:
22.16
2eimJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.95A 2einC-4ma5A:
undetectable
2einJ-4ma5A:
undetectable
2einC-4ma5A:
22.16
2einJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LYS A 138
LEU A 137
GLN A 149
LEU A 124
ANP  A 401 ( 2.8A)
None
ANP  A 401 ( 4.5A)
None
1.03A 2einC-4ma5A:
undetectable
2einJ-4ma5A:
undetectable
2einC-4ma5A:
22.16
2einJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 6 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.97A 2einP-4ma5A:
undetectable
2einW-4ma5A:
undetectable
2einP-4ma5A:
22.16
2einW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 5 PRO A 262
ILE A 287
GLY A 242
TYR A 240
None
1.11A 2jkjD-4ma5A:
undetectable
2jkjD-4ma5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 5 PRO A 262
ILE A 287
GLY A 242
TYR A 240
None
1.11A 2jkjF-4ma5A:
undetectable
2jkjF-4ma5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 8 GLN A 186
SER A 185
TYR A 199
SER A 214
None
1.21A 2xz5C-4ma5A:
undetectable
2xz5D-4ma5A:
undetectable
2xz5C-4ma5A:
23.19
2xz5D-4ma5A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 6 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.97A 2zxwP-4ma5A:
undetectable
2zxwW-4ma5A:
undetectable
2zxwP-4ma5A:
22.16
2zxwW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 6 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
1.01A 3ag1C-4ma5A:
undetectable
3ag1J-4ma5A:
undetectable
3ag1C-4ma5A:
22.16
3ag1J-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.92A 3ag2C-4ma5A:
undetectable
3ag2C-4ma5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.91A 3ag2P-4ma5A:
undetectable
3ag2W-4ma5A:
undetectable
3ag2P-4ma5A:
22.16
3ag2W-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.91A 3ag4P-4ma5A:
undetectable
3ag4W-4ma5A:
undetectable
3ag4P-4ma5A:
22.16
3ag4W-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.95A 3asnC-4ma5A:
undetectable
3asnJ-4ma5A:
undetectable
3asnC-4ma5A:
22.16
3asnJ-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
5 / 9 GLY A 242
ALA A 190
ILE A 187
LEU A 234
VAL A 235
None
0.86A 3u7sB-4ma5A:
undetectable
3u7sB-4ma5A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.97A 3x2qP-4ma5A:
undetectable
3x2qW-4ma5A:
undetectable
3x2qP-4ma5A:
22.16
3x2qW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 5 GLU A 363
MET A 309
LEU A 315
HIS A 324
None
1.35A 4xi3B-4ma5A:
undetectable
4xi3B-4ma5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 5 LEU A 303
GLU A 363
MET A 309
LEU A 315
None
1.34A 4xi3B-4ma5A:
undetectable
4xi3B-4ma5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
3 / 3 SER A 362
GLU A 213
GLU A 349
None
0.80A 4ymgB-4ma5A:
4.3
4ymgB-4ma5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 LEU A 137
GLN A 149
PHE A 150
LEU A 124
None
ANP  A 401 ( 4.5A)
None
None
0.93A 5b1bP-4ma5A:
undetectable
5b1bW-4ma5A:
undetectable
5b1bP-4ma5A:
22.16
5b1bW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
3 / 3 VAL A 235
GLN A 228
CYH A 188
None
0.82A 5icxC-4ma5A:
undetectable
5icxF-4ma5A:
undetectable
5icxC-4ma5A:
20.98
5icxF-4ma5A:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 7 GLY A   7
LYS A  31
ASP A  45
ASN A  68
None
0.93A 5mvsA-4ma5A:
4.2
5mvsA-4ma5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
4 / 8 GLY A   7
LYS A  31
ASP A  45
ASN A  68
None
0.94A 5mvsB-4ma5A:
4.2
5mvsB-4ma5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
5 / 11 SER A  95
GLY A 268
SER A 271
ALA A 275
VAL A 264
NA  A 404 (-4.7A)
None
None
None
None
1.35A 6hu9A-4ma5A:
undetectable
6hu9E-4ma5A:
undetectable
6hu9I-4ma5A:
undetectable
6hu9A-4ma5A:
22.62
6hu9E-4ma5A:
21.27
6hu9I-4ma5A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis)
5 / 10 SER A  95
GLY A 268
SER A 271
ALA A 275
VAL A 264
NA  A 404 (-4.7A)
None
None
None
None
1.31A 6hu9L-4ma5A:
undetectable
6hu9P-4ma5A:
undetectable
6hu9T-4ma5A:
undetectable
6hu9L-4ma5A:
22.62
6hu9P-4ma5A:
21.27
6hu9T-4ma5A:
10.89