SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 11 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.41A 1fkpA-4maeA:
undetectable		 1fkpA-4maeA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 10 ASP A 106
GLY A 531
VAL A 108
ARG A  52
GLY A 534
 None
PQQ  A 602 (-3.2A)
PQQ  A 602 (-4.8A)
None
None
 1.42A 1fohA-4maeA:
undetectable		 1fohA-4maeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 10 ASP A 106
GLY A 531
VAL A 108
ARG A  52
GLY A 534
 None
PQQ  A 602 (-3.2A)
PQQ  A 602 (-4.8A)
None
None
 1.42A 1fohB-4maeA:
undetectable		 1fohB-4maeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 8 LEU A 192
VAL A 168
GLY A 167
TYR A 194
 None
 1.01A 1jlfA-4maeA:
undetectable
1jlfB-4maeA:
undetectable		 1jlfA-4maeA:
22.82
1jlfB-4maeA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ILE A 507
GLY A  57
VAL A 525
ALA A 156
GLY A 469
 None
 1.16A 1kiaB-4maeA:
undetectable		 1kiaB-4maeA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 10 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.43A 1lw0A-4maeA:
undetectable		 1lw0A-4maeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 LEU A 192
VAL A 168
GLY A 167
TYR A 194
 None
 0.90A 1lweA-4maeA:
undetectable		 1lweA-4maeA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 9 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.46A 1lwfA-4maeA:
undetectable		 1lwfA-4maeA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 9 GLY A 569
GLU A  55
GLY A  53
GLY A 509
GLY A  56
 None
PQQ  A 602 (-2.5A)
None
None
None
 1.06A 1mxdA-4maeA:
undetectable		 1mxdA-4maeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 11 GLY A 569
GLU A  55
GLY A  53
GLY A 509
GLY A  56
 None
PQQ  A 602 (-2.5A)
None
None
None
 1.04A 1mxgA-4maeA:
undetectable		 1mxgA-4maeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ILE A 507
GLY A  57
VAL A 525
ALA A 156
GLY A 469
 None
 1.16A 1nbiA-4maeA:
undetectable		 1nbiA-4maeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ILE A 507
GLY A  57
VAL A 525
ALA A 156
GLY A 469
 None
 1.15A 1nbiB-4maeA:
undetectable		 1nbiB-4maeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 9 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.44A 1vrtA-4maeA:
undetectable		 1vrtA-4maeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 6 TYR A 348
GLY A 435
ASP A 440
ASN A 407
 None
 1.16A 2g72A-4maeA:
undetectable		 2g72A-4maeA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 10 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.47A 2hnyA-4maeA:
undetectable		 2hnyA-4maeA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 GLU A  55
PRO A 157
MET A  16
GLY A  56
 PQQ  A 602 (-2.5A)
None
None
None
 1.21A 2hs1B-4maeA:
undetectable		 2hs1B-4maeA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 VAL A 430
VAL A 426
GLY A 427
TRP A 260
 None
None
None
15P  A 603 (-4.9A)
 1.15A 2p2fA-4maeA:
undetectable		 2p2fA-4maeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 9 LEU A 503
GLU A 570
GLY A 528
GLY A 568
LEU A 571
 None
 1.19A 2qmmA-4maeA:
undetectable		 2qmmA-4maeA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 THR A 293
PRO A 294
ARG A 369
PRO A 362
 None
 1.02A 2v2gA-4maeA:
undetectable
2v2gB-4maeA:
undetectable		 2v2gA-4maeA:
17.47
2v2gB-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 PRO A  72
THR A  92
PRO A  93
VAL A  94
 None
 1.03A 2v2gA-4maeA:
undetectable
2v2gB-4maeA:
undetectable		 2v2gA-4maeA:
17.47
2v2gB-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 PRO A 362
THR A 293
PRO A 294
ARG A 369
 None
 1.05A 2v2gA-4maeA:
undetectable
2v2gB-4maeA:
undetectable		 2v2gA-4maeA:
17.47
2v2gB-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 PRO A  72
THR A  92
PRO A  93
VAL A  94
 None
 1.01A 2v2gC-4maeA:
undetectable
2v2gD-4maeA:
undetectable		 2v2gC-4maeA:
17.47
2v2gD-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 PRO A 362
THR A 293
PRO A 294
ARG A 369
 None
 1.02A 2v2gC-4maeA:
undetectable
2v2gD-4maeA:
undetectable		 2v2gC-4maeA:
17.47
2v2gD-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 8 VAL A 403
PRO A 404
PRO A 470
GLU A 305
 None
 0.86A 2v32C-4maeA:
undetectable
2v32D-4maeA:
undetectable		 2v32C-4maeA:
17.47
2v32D-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 8 PRO A  72
THR A  92
PRO A  93
VAL A  94
 None
 0.96A 2v41C-4maeA:
undetectable
2v41D-4maeA:
undetectable		 2v41C-4maeA:
17.47
2v41D-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 8 PRO A 362
THR A 293
PRO A 294
ARG A 369
 None
 1.01A 2v41C-4maeA:
undetectable
2v41D-4maeA:
undetectable		 2v41C-4maeA:
17.47
2v41D-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 THR A 293
PRO A 294
ARG A 369
PRO A 362
 None
 1.05A 2v41E-4maeA:
undetectable
2v41F-4maeA:
undetectable		 2v41E-4maeA:
17.47
2v41F-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 PRO A  72
THR A  92
PRO A  93
VAL A  94
 None
 1.05A 2v41E-4maeA:
undetectable
2v41F-4maeA:
undetectable		 2v41E-4maeA:
17.47
2v41F-4maeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 6 VAL A 108
VAL A 107
GLN A  95
ARG A  52
 PQQ  A 602 (-4.8A)
None
None
None
 1.23A 3bjwF-4maeA:
undetectable		 3bjwF-4maeA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 ASN A 256
ARG A 326
ASN A 304
HIS A 323
 CE  A 601 ( 3.4A)
PQQ  A 602 (-2.7A)
None
None
 1.49A 3frqA-4maeA:
undetectable		 3frqA-4maeA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 11 SER A 273
THR A 275
GLY A 177
THR A 236
ASP A 301
 None
None
None
PQQ  A 602 (-3.1A)
CE  A 601 ( 2.3A)
 1.32A 3mg0H-4maeA:
undetectable
3mg0I-4maeA:
undetectable		 3mg0H-4maeA:
15.77
3mg0I-4maeA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 8 ASP A 299
ASP A 301
GLY A 302
GLU A 172
ARG A 110
 15P  A 603 (-2.7A)
CE  A 601 ( 2.3A)
None
CE  A 601 (-2.5A)
PQQ  A 602 (-3.3A)
 1.41A 3s3mA-4maeA:
undetectable		 3s3mA-4maeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ASN A 109
VAL A  75
ILE A 119
ILE A 128
PRO A  93
 None
 0.98A 3spkB-4maeA:
undetectable		 3spkB-4maeA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ARG A 178
GLN A 196
GLY A 171
GLY A 235
GLU A 151
 None
None
PQQ  A 602 (-3.1A)
None
None
 1.07A 3sxjA-4maeA:
undetectable		 3sxjA-4maeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ARG A 178
GLN A 196
GLY A 174
GLY A 234
GLU A 151
 None
 1.03A 3sxjA-4maeA:
undetectable		 3sxjA-4maeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 GLN A 196
GLY A 171
GLY A 235
GLU A 151
TYR A 425
 None
PQQ  A 602 (-3.1A)
None
None
None
 1.03A 3sxjA-4maeA:
undetectable		 3sxjA-4maeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ARG A 178
GLN A 196
GLY A 171
GLY A 235
GLU A 151
 None
None
PQQ  A 602 (-3.1A)
None
None
 1.07A 3sxjB-4maeA:
undetectable		 3sxjB-4maeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ARG A 178
GLN A 196
GLY A 174
GLY A 234
GLU A 151
 None
 1.01A 3sxjB-4maeA:
undetectable		 3sxjB-4maeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 GLN A 196
GLY A 171
GLY A 235
GLU A 151
TYR A 425
 None
PQQ  A 602 (-3.1A)
None
None
None
 1.03A 3sxjB-4maeA:
undetectable		 3sxjB-4maeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 TYR A  26
VAL A 472
SER A 395
GLY A 476
 None
 1.45A 3v4tA-4maeA:
undetectable
3v4tD-4maeA:
undetectable		 3v4tA-4maeA:
22.92
3v4tD-4maeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		3 / 3 ARG A 369
ARG A 265
ASP A 269
 None
 0.95A 3wipG-4maeA:
undetectable
3wipH-4maeA:
undetectable		 3wipG-4maeA:
17.04
3wipH-4maeA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 TYR A 557
GLY A 534
ALA A 556
LEU A 541
VAL A 537
 None
 1.27A 4azsA-4maeA:
undetectable		 4azsA-4maeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 ARG A 265
THR A 370
THR A 259
GLY A 427
 None
 0.72A 4eq4A-4maeA:
undetectable		 4eq4A-4maeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 ARG A 265
THR A 370
THR A 259
GLY A 427
 None
 0.69A 4eqlA-4maeA:
undetectable		 4eqlA-4maeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 ARG A 265
THR A 370
THR A 259
GLY A 427
 None
 0.69A 4eqlB-4maeA:
undetectable		 4eqlB-4maeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 8 VAL A 164
HIS A 144
ILE A 128
ALA A 145
 None
 0.94A 4eyzB-4maeA:
undetectable		 4eyzB-4maeA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 GLY A 170
GLY A 171
ASN A 256
GLU A 151
 PQQ  A 602 (-3.6A)
PQQ  A 602 (-3.1A)
CE  A 601 ( 3.4A)
None
 1.26A 4fglC-4maeA:
undetectable		 4fglC-4maeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 4 TYR A  85
THR A  48
VAL A  67
ILE A  87
 None
 1.49A 4jx1F-4maeA:
undetectable		 4jx1F-4maeA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 ARG A 265
THR A 370
THR A 259
GLY A 427
 None
 0.65A 4l39B-4maeA:
undetectable		 4l39B-4maeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 10 LEU A 333
ALA A 392
PHE A 324
PHE A 401
LEU A 311
 None
 1.28A 4la0A-4maeA:
undetectable		 4la0A-4maeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 9 LEU A 333
ALA A 392
PHE A 324
PHE A 401
LEU A 311
 None
 1.32A 4la0B-4maeA:
undetectable		 4la0B-4maeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 PRO A 281
GLY A 284
ASP A 334
ASP A 205
 None
 1.05A 4n48B-4maeA:
undetectable		 4n48B-4maeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 6 ASP A 325
HIS A 323
GLU A 305
ARG A 326
 None
None
None
PQQ  A 602 (-2.7A)
 1.23A 4qyqC-4maeA:
undetectable		 4qyqC-4maeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 11 ASN A 109
ILE A 153
THR A 237
GLY A 167
THR A 123
 None
 1.13A 4xt7A-4maeA:
undetectable		 4xt7A-4maeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 GLY A  12
TYR A  26
SER A  27
GLU A  10
 None
 1.22A 4xueA-4maeA:
undetectable		 4xueA-4maeA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 4 VAL A 100
ALA A  99
ASN A  96
GLN A  95
 None
 1.32A 4zgfA-4maeA:
undetectable		 4zgfA-4maeA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 11 SER A 273
THR A 275
GLY A 177
THR A 236
ASP A 301
 None
None
None
PQQ  A 602 (-3.1A)
CE  A 601 ( 2.3A)
 1.28A 5bxnV-4maeA:
undetectable
5bxnW-4maeA:
undetectable		 5bxnV-4maeA:
16.81
5bxnW-4maeA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 6 TYR A 348
TYR A 300
GLY A 378
GLU A 437
 None
 1.32A 5emlA-4maeA:
undetectable		 5emlA-4maeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		3 / 3 TRP A 351
GLU A 364
ASP A 296
 None
 1.03A 5gqbA-4maeA:
undetectable		 5gqbA-4maeA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 11 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.44A 5hbmA-4maeA:
undetectable		 5hbmA-4maeA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 6 ASP A 325
HIS A 323
GLU A 305
ARG A 326
 None
None
None
PQQ  A 602 (-2.7A)
 1.23A 5hpwC-4maeA:
undetectable		 5hpwC-4maeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 ILE A 508
VAL A 107
ALA A 103
GLY A 171
THR A 236
 None
None
None
PQQ  A 602 (-3.1A)
PQQ  A 602 (-3.1A)
 1.19A 5igiA-4maeA:
undetectable		 5igiA-4maeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		3 / 3 VAL A 202
SER A 195
TRP A 272
 None
 0.89A 5jwaA-4maeA:
undetectable		 5jwaA-4maeA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		3 / 3 TYR A 290
ALA A 343
TYR A 331
 None
 0.71A 5uunB-4maeA:
undetectable		 5uunB-4maeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 12 PRO A 281
GLY A 284
ASP A 334
GLY A 338
ASP A 205
 None
 1.24A 5wwsB-4maeA:
undetectable		 5wwsB-4maeA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 7 ASN A 406
ASP A 388
ASP A 301
GLY A 302
 None
PQQ  A 602 (-2.7A)
CE  A 601 ( 2.3A)
None
 1.13A 5x7pA-4maeA:
undetectable		 5x7pA-4maeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 9 ALA A 564
VAL A 529
VAL A 567
SER A 505
GLY A 504
 None
 1.18A 6bklA-4maeA:
undetectable
6bklB-4maeA:
undetectable
6bklC-4maeA:
undetectable
6bklD-4maeA:
undetectable		 6bklA-4maeA:
3.64
6bklB-4maeA:
3.64
6bklC-4maeA:
3.64
6bklD-4maeA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		3 / 3 GLN A  95
TYR A  71
ASN A  73
 None
 1.06A 6dwdC-4maeA:
undetectable		 6dwdC-4maeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 THR A 222
THR A 275
GLN A 291
ASP A 301
 None
None
None
CE  A 601 ( 2.3A)
 1.43A 6ectA-4maeA:
undetectable		 6ectA-4maeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 THR A 222
THR A 275
GLN A 291
ASP A 301
 None
None
None
CE  A 601 ( 2.3A)
 1.39A 6ecxA-4maeA:
undetectable		 6ecxA-4maeA:
19.13