SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mb2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		5 / 11 LEU A  99
LEU A 127
VAL A  80
GLY A  78
ARG A 110
 None
 1.43A 1y4lB-4mb2A:
undetectable		 1y4lB-4mb2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		4 / 5 LEU A 235
ASN A 231
VAL A 197
ALA A 189
 None
 1.11A 2cizA-4mb2A:
undetectable		 2cizA-4mb2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		4 / 4 LEU A 249
THR A 247
ILE A  47
HIS A 241
 None
 0.98A 2jfaB-4mb2A:
undetectable		 2jfaB-4mb2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		5 / 12 GLY A  78
GLY A  33
ILE A 101
ALA A  81
LEU A 118
 None
 0.93A 2plwA-4mb2A:
undetectable		 2plwA-4mb2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		4 / 5 ILE A 178
TYR A 204
MET A 207
THR A 208
 None
 1.35A 3abkN-4mb2A:
undetectable
3abkW-4mb2A:
undetectable		 3abkN-4mb2A:
19.23
3abkW-4mb2A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		4 / 6 ILE A  47
ILE A 254
LEU A 182
PHE A  43
 None
None
ATP  A 301 (-3.8A)
None
 0.96A 3adsA-4mb2A:
undetectable		 3adsA-4mb2A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		4 / 7 ILE A  47
ILE A 254
LEU A 182
PHE A  43
 None
None
ATP  A 301 (-3.8A)
None
 0.92A 3adxA-4mb2A:
undetectable		 3adxA-4mb2A:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		9 / 9 ALA A  36
ARG A  39
GLY A  40
LEU A 161
ASP A 181
LEU A 182
ASN A 183
ASN A 199
ILE A 200
 ATP  A 301 (-3.3A)
ATP  A 301 (-3.2A)
ATP  A 301 (-3.4A)
ATP  A 301 (-3.9A)
ATP  A 301 (-2.7A)
ATP  A 301 (-3.8A)
None
ATP  A 301 (-3.0A)
ATP  A 301 (-4.3A)
 0.15A 3wdmA-4mb2A:
43.2		 3wdmA-4mb2A:
90.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		5 / 9 ARG A  39
GLY A  40
LEU A 182
ASN A 183
ILE A 180
 ATP  A 301 (-3.2A)
ATP  A 301 (-3.4A)
ATP  A 301 (-3.8A)
None
None
 1.26A 3wdmA-4mb2A:
43.2		 3wdmA-4mb2A:
90.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		10 / 10 ALA A  36
ARG A  39
GLY A  40
LEU A  83
LEU A 161
ASP A 181
LEU A 182
ASN A 183
ASN A 199
ILE A 200
 ATP  A 301 (-3.3A)
ATP  A 301 (-3.2A)
ATP  A 301 (-3.4A)
None
ATP  A 301 (-3.9A)
ATP  A 301 (-2.7A)
ATP  A 301 (-3.8A)
None
ATP  A 301 (-3.0A)
ATP  A 301 (-4.3A)
 0.49A 3wdmB-4mb2A:
41.7		 3wdmB-4mb2A:
90.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		9 / 9 ALA A  36
GLY A  40
LEU A  83
LEU A 161
ASP A 181
LEU A 182
ASN A 183
ASN A 199
ILE A 200
 ATP  A 301 (-3.3A)
ATP  A 301 (-3.4A)
None
ATP  A 301 (-3.9A)
ATP  A 301 (-2.7A)
ATP  A 301 (-3.8A)
None
ATP  A 301 (-3.0A)
ATP  A 301 (-4.3A)
 0.13A 3wdmC-4mb2A:
42.8		 3wdmC-4mb2A:
90.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE
(Thermococcus
onnurineus) 		10 / 10 ALA A  36
ARG A  39
GLY A  40
LEU A  83
LEU A 161
ASP A 181
LEU A 182
ASN A 183
ASN A 199
ILE A 200
 ATP  A 301 (-3.3A)
ATP  A 301 (-3.2A)
ATP  A 301 (-3.4A)
None
ATP  A 301 (-3.9A)
ATP  A 301 (-2.7A)
ATP  A 301 (-3.8A)
None
ATP  A 301 (-3.0A)
ATP  A 301 (-4.3A)
 0.59A 3wdmD-4mb2A:
39.7		 3wdmD-4mb2A:
90.80