SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
 1.13A 1bsxA-4mb5A:
undetectable		 1bsxA-4mb5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
 1.13A 1bsxB-4mb5A:
undetectable		 1bsxB-4mb5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 8 LEU A 478
VAL A 498
THR A 470
ASP A 443
 None
 1.12A 1dz9A-4mb5A:
undetectable		 1dz9A-4mb5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 9 PHE A  70
GLY A 117
ASP A 151
GLN A 153
TRP A 311
 NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-3.0A)
NAG  A 608 (-3.5A)
 0.84A 1e9lA-4mb5A:
19.8		 1e9lA-4mb5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 9 PHE A  70
GLY A 117
ASP A 151
GLN A 153
TYR A 220
 NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-3.0A)
NAG  A 609 (-4.4A)
 0.78A 1e9lA-4mb5A:
19.8		 1e9lA-4mb5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 9 TYR A  36
PHE A  70
GLY A 117
ASP A 151
TRP A 311
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 608 (-3.5A)
 0.82A 1e9lA-4mb5A:
19.8		 1e9lA-4mb5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 9 TYR A  36
PHE A  70
GLY A 117
ASP A 151
TYR A 220
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
 0.73A 1e9lA-4mb5A:
19.8		 1e9lA-4mb5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4mb5 CHITINASE 60
(Moritella
marina) 		3 / 3 PHE A 366
TYR A 404
PRO A 368
 None
 0.74A 1mcnA-4mb5A:
2.6
1mcnB-4mb5A:
undetectable
1mcnP-4mb5A:
undetectable		 1mcnA-4mb5A:
17.40
1mcnB-4mb5A:
17.40
1mcnP-4mb5A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4mb5 CHITINASE 60
(Moritella
marina) 		3 / 3 PHE A 442
TYR A 480
PRO A 444
 None
 0.67A 1mcnA-4mb5A:
2.6
1mcnB-4mb5A:
undetectable
1mcnP-4mb5A:
undetectable		 1mcnA-4mb5A:
17.40
1mcnB-4mb5A:
17.40
1mcnP-4mb5A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 8 LEU A 478
VAL A 498
THR A 470
ASP A 443
 None
 1.06A 1o76B-4mb5A:
undetectable		 1o76B-4mb5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
 1.27A 1y0xX-4mb5A:
undetectable		 1y0xX-4mb5A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 10 PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.99A 2a3bB-4mb5A:
20.9		 2a3bB-4mb5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		7 / 12 TYR A  36
TRP A  40
PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 NAG  A 608 ( 3.8A)
PEG  A 614 (-3.7A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.99A 2a3cA-4mb5A:
20.8		 2a3cA-4mb5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		6 / 12 TRP A  40
PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 PEG  A 614 (-3.7A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.96A 2a3cB-4mb5A:
21.0		 2a3cB-4mb5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 5 LEU A 112
ASP A 149
GLY A 272
VAL A  65
 None
 0.84A 2aojA-4mb5A:
undetectable		 2aojA-4mb5A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4mb5 CHITINASE 60
(Moritella
marina) 		3 / 3 LYS A 171
ASP A 376
ASP A 385
 None
 0.99A 2br4A-4mb5A:
undetectable		 2br4A-4mb5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 7 MET A 445
VAL A 498
THR A 434
THR A 432
 None
 1.22A 2kotA-4mb5A:
undetectable		 2kotA-4mb5A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 7 GLY A 223
THR A 282
GLN A 222
PHE A 192
 NDG  A 611 (-3.6A)
None
NAG  A 610 (-3.2A)
None
 1.09A 2qx4A-4mb5A:
undetectable
2qx4B-4mb5A:
undetectable		 2qx4A-4mb5A:
18.49
2qx4B-4mb5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 9 TYR A  36
PHE A  70
GLY A 116
ASP A 151
GLN A 218
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
None
NAG  A 608 (-3.4A)
NAG  A 608 (-3.4A)
 1.10A 2uy4A-4mb5A:
24.0		 2uy4A-4mb5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		8 / 9 TYR A  36
PHE A  70
GLY A 117
ALA A 118
ASP A 151
GLN A 218
TYR A 220
TRP A 311
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 609 (-3.4A)
NAG  A 608 (-3.4A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.33A 2uy4A-4mb5A:
24.0		 2uy4A-4mb5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		3 / 3 MET A 445
VAL A 500
GLU A 441
 None
 0.92A 2x9gA-4mb5A:
undetectable		 2x9gA-4mb5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4mb5 CHITINASE 60
(Moritella
marina) 		7 / 11 TYR A  36
PHE A  70
GLY A 117
ALA A 118
ASP A 151
ALA A 279
TRP A 311
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 609 (-3.4A)
NAG  A 608 (-3.4A)
None
NAG  A 608 (-3.5A)
 1.06A 2xtkA-4mb5A:
23.8		 2xtkA-4mb5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4mb5 CHITINASE 60
(Moritella
marina) 		10 / 11 TYR A  36
PHE A  70
GLY A 117
ALA A 118
ASP A 151
GLN A 218
TYR A 220
ASN A 221
ALA A 280
TRP A 311
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 609 (-3.4A)
NAG  A 608 (-3.4A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.4A)
NAG  A 608 (-3.7A)
NAG  A 608 (-3.5A)
 0.61A 2xtkA-4mb5A:
23.8		 2xtkA-4mb5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4mb5 CHITINASE 60
(Moritella
marina) 		8 / 10 TYR A  36
PHE A  70
GLY A 117
ALA A 118
ASP A 151
GLN A 218
TYR A 220
TRP A 311
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 609 (-3.4A)
NAG  A 608 (-3.4A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.41A 2xtkB-4mb5A:
23.8		 2xtkB-4mb5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 11 LEU A 104
ILE A 101
PHE A 145
PHE A  97
VAL A  54
 None
 1.31A 3a9eB-4mb5A:
undetectable		 3a9eB-4mb5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 TYR A 177
HIS A 176
ASP A 141
SER A  27
ILE A  25
 None
 1.42A 3b7pC-4mb5A:
undetectable		 3b7pC-4mb5A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		6 / 11 TYR A  36
PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 NAG  A 608 ( 3.8A)
NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 1.03A 3g6mA-4mb5A:
20.3		 3g6mA-4mb5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 6 ILE A 101
ASP A  30
GLY A 108
VAL A  34
 None
 0.89A 3n3iA-4mb5A:
undetectable		 3n3iA-4mb5A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		3 / 3 TYR A 377
ASP A 267
ASP A 213
 None
 0.69A 3ou7B-4mb5A:
undetectable		 3ou7B-4mb5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 5 TYR A 211
ILE A 255
LEU A 254
LYS A 263
 None
 1.18A 3sueC-4mb5A:
undetectable		 3sueC-4mb5A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 ILE A 122
LEU A 152
ILE A 150
PRO A  82
ILE A  81
 None
None
None
None
PEG  A 604 (-3.9A)
 1.06A 3vrmA-4mb5A:
undetectable		 3vrmA-4mb5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 11 PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.39A 3wqvA-4mb5A:
21.5		 3wqvA-4mb5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 11 PHE A  70
GLY A 117
ASP A 151
TYR A 220
TRP A 311
 NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 608 (-3.4A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.39A 3wqwA-4mb5A:
21.5		 3wqwA-4mb5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 VAL A 270
PHE A 337
ARG A 306
ILE A 338
PHE A 295
 None
 1.41A 4c49D-4mb5A:
undetectable		 4c49D-4mb5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 7 ILE A 255
LEU A 305
MET A 309
GLY A 272
 None
 1.03A 4hc3A-4mb5A:
undetectable		 4hc3A-4mb5A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 GLY A  49
ASP A 278
ILE A 277
GLN A  47
ASN A 323
 None
 0.93A 4pooB-4mb5A:
undetectable		 4pooB-4mb5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 12 GLY A  49
ASP A 278
ILE A 277
GLN A  47
ASN A 324
 None
 1.00A 4pooB-4mb5A:
undetectable		 4pooB-4mb5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 8 THR A 351
PRO A 350
VAL A 406
SER A 405
 None
 1.21A 4qknA-4mb5A:
undetectable		 4qknA-4mb5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4mb5 CHITINASE 60
(Moritella
marina) 		5 / 10 GLY A 226
ASN A 238
ILE A 229
LEU A 227
TYR A 249
 GLY  A 613 (-4.7A)
None
None
None
None
 1.13A 4xj7A-4mb5A:
undetectable
4xj7B-4mb5A:
undetectable		 4xj7A-4mb5A:
19.69
4xj7B-4mb5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 5 GLN A 218
PRO A 190
ILE A 150
ASP A 149
 NAG  A 608 (-3.4A)
None
None
None
 1.41A 4z4hA-4mb5A:
3.5		 4z4hA-4mb5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 6 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 None
 1.04A 5a06A-4mb5A:
undetectable		 5a06A-4mb5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 5 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 None
 1.08A 5a06B-4mb5A:
undetectable		 5a06B-4mb5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 5 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 None
 1.07A 5a06D-4mb5A:
undetectable		 5a06D-4mb5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 5 ASP A 290
LYS A 293
ARG A 297
ILE A 247
 None
 1.08A 5a06F-4mb5A:
undetectable		 5a06F-4mb5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 8 PHE A  70
GLY A 117
TYR A 220
TRP A 311
 NAG  A 608 (-4.4A)
NAG  A 608 ( 3.9A)
NAG  A 609 (-4.4A)
NAG  A 608 (-3.5A)
 0.41A 5gqbA-4mb5A:
20.0		 5gqbA-4mb5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 5 ILE A 264
LEU A 273
GLY A 272
PHE A 271
 None
 0.91A 5kmdC-4mb5A:
undetectable
5kmdD-4mb5A:
undetectable		 5kmdC-4mb5A:
18.10
5kmdD-4mb5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 7 ASN A 216
ASP A 149
GLY A 147
ASN A  67
 None
 1.13A 5x7pA-4mb5A:
3.9		 5x7pA-4mb5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 4mb5 CHITINASE 60
(Moritella
marina) 		4 / 7 GLY A 379
ASP A 347
MET A 348
TYR A 377
 None
 1.40A 6ag0A-4mb5A:
12.0		 6ag0A-4mb5A:
13.39