SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
3 / 3 TRP B 153
VAL B 155
TRP B 157
K  B 605 ( 4.4A)
None
None
1.34A 1c4dC-4mbgB:
undetectable
1c4dD-4mbgB:
undetectable
1c4dC-4mbgB:
7.50
1c4dD-4mbgB:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
5 / 11 ARG A 197
LEU A 226
GLU A 230
ALA A 257
GLY A 217
None
1.34A 1cmaA-4mbgA:
undetectable
1cmaB-4mbgA:
undetectable
1cmaA-4mbgA:
16.09
1cmaB-4mbgA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 10 ARG B 175
LEU A  30
GLU B 138
ALA B 158
GLY B 161
None
1.04A 1cmcA-4mbgB:
undetectable
1cmcB-4mbgB:
undetectable
1cmcA-4mbgB:
13.00
1cmcB-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 VAL B 243
ILE A  78
ILE A  66
ASN A  70
TYR A  39
None
1.20A 1fm4A-4mbgB:
undetectable
1fm4A-4mbgB:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 11 LEU B 441
LEU B 438
ALA B 437
ILE B 121
LEU B 406
None
1.18A 1g50A-4mbgB:
undetectable
1g50A-4mbgB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 11 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
0.94A 1h9zA-4mbgB:
undetectable
1h9zA-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 11 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
0.90A 1ha2A-4mbgB:
undetectable
1ha2A-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 7 SER B 463
HIS B 495
TYR B 204
LEU B 208
None
None
FPP  B 601 ( 4.9A)
None
1.15A 1ibgL-4mbgB:
undetectable
1ibgL-4mbgB:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 11 LEU B 400
LEU B 345
ALA B 315
GLN B 380
HIS B 370
None
1.36A 1iiuA-4mbgB:
undetectable
1iiuA-4mbgB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 7 PRO B 152
ALA B 149
SER B 203
ALA B 201
None
None
None
K  B 605 (-3.4A)
1.04A 1k5qA-4mbgB:
undetectable
1k5qB-4mbgB:
undetectable
1k5qA-4mbgB:
19.29
1k5qB-4mbgB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 12 LEU B 400
LEU B 345
ALA B 315
GLN B 380
HIS B 370
None
1.22A 1kt4A-4mbgB:
undetectable
1kt4A-4mbgB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 7 PHE B 498
ALA B 464
PHE B 465
PHE B 461
None
0.98A 1lqtA-4mbgB:
undetectable
1lqtA-4mbgB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 7 PHE B 498
ALA B 464
PHE B 465
PHE B 461
None
0.98A 1lquA-4mbgB:
undetectable
1lquA-4mbgB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 8 SER B 346
ILE A 327
GLY B 354
GLY B 373
None
0.70A 1me7A-4mbgB:
undetectable
1me7A-4mbgB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 ALA B 158
GLY B 161
ARG B 175
LEU A  30
GLU B 138
None
0.98A 1mj2A-4mbgB:
undetectable
1mj2B-4mbgB:
undetectable
1mj2A-4mbgB:
13.00
1mj2B-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 ALA B 158
GLY B 161
ARG B 175
LEU A  30
GLU B 138
None
1.03A 1mj2C-4mbgB:
undetectable
1mj2D-4mbgB:
undetectable
1mj2C-4mbgB:
13.00
1mj2D-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 ALA B 158
GLY B 161
ARG B 175
LEU A  30
GLU B 138
None
1.04A 1mjoC-4mbgB:
undetectable
1mjoD-4mbgB:
undetectable
1mjoC-4mbgB:
13.00
1mjoD-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 11 ARG B 175
LEU A  30
GLU B 138
ALA B 158
GLY B 161
None
1.00A 1mjqA-4mbgB:
undetectable
1mjqB-4mbgB:
undetectable
1mjqA-4mbgB:
13.00
1mjqB-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 10 ARG B 175
LEU A  30
GLU B 138
ALA B 158
GLY B 161
None
0.97A 1mjqC-4mbgB:
undetectable
1mjqD-4mbgB:
undetectable
1mjqC-4mbgB:
13.00
1mjqD-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 ALA B 158
GLY B 161
ARG B 175
LEU A  30
GLU B 138
None
1.03A 1mjqC-4mbgB:
undetectable
1mjqD-4mbgB:
undetectable
1mjqC-4mbgB:
13.00
1mjqD-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 11 ARG B 175
LEU A  30
GLU B 138
ALA B 158
GLY B 161
None
0.98A 1mjqI-4mbgB:
undetectable
1mjqJ-4mbgB:
undetectable
1mjqI-4mbgB:
13.00
1mjqJ-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 ALA B 158
GLY B 161
ARG B 175
LEU A  30
GLU B 138
None
1.03A 1mjqI-4mbgB:
undetectable
1mjqJ-4mbgB:
undetectable
1mjqI-4mbgB:
13.00
1mjqJ-4mbgB:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 12 LEU B 438
LEU B 441
GLN B 445
LEU B 130
CYH B 163
None
1.03A 1sqnB-4mbgB:
undetectable
1sqnB-4mbgB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
3 / 3 GLN B 415
HIS B 129
ARG B 126
None
1.05A 1zlqA-4mbgB:
undetectable
1zlqA-4mbgB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
6 / 11 SER B 203
VAL B 207
ILE B 222
LEU B 264
LEU B 231
LEU B 266
None
1.40A 2a15A-4mbgB:
undetectable
2a15A-4mbgB:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 9 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
0.92A 2bxeA-4mbgB:
undetectable
2bxeA-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 10 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
0.94A 2bxeB-4mbgB:
undetectable
2bxeB-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 8 SER B 463
PHE B 465
ALA B 505
LEU B 263
None
1.07A 2bxkA-4mbgB:
undetectable
2bxkA-4mbgB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 12 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
0.90A 2bxpA-4mbgB:
undetectable
2bxpA-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 10 ALA B 315
PHE B 316
ALA B 320
LEU B 324
LEU B 345
None
0.92A 2bxqA-4mbgB:
undetectable
2bxqA-4mbgB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 12 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
0.89A 2bxqA-4mbgB:
undetectable
2bxqA-4mbgB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
3 / 3 TRP A 295
ALA A 297
VAL A 299
None
0.96A 2izqC-4mbgA:
undetectable
2izqD-4mbgA:
undetectable
2izqC-4mbgA:
4.03
2izqD-4mbgA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
4 / 6 ASP B 148
HIS A  73
TYR A  74
ASN B 185
EDO  A 401 (-2.8A)
EDO  A 402 (-4.1A)
None
None
1.22A 2zs9A-4mbgB:
undetectable
2zs9A-4mbgB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 4 SER B 475
GLY B 483
GLY B 477
GLY B 479
None
0.86A 3bogB-4mbgB:
undetectable
3bogD-4mbgB:
undetectable
3bogB-4mbgB:
undetectable
3bogD-4mbgB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 8 HIS B  69
GLY B 120
ASN B 117
TYR B 119
None
1.34A 3ccfA-4mbgB:
undetectable
3ccfA-4mbgB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
4 / 8 VAL A 101
HIS A 105
VAL A  76
GLN A 110
None
0.81A 3fi0B-4mbgA:
undetectable
3fi0B-4mbgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
4 / 8 GLU A 264
SER A 263
VAL A 299
TRP A 295
None
1.37A 3nlyA-4mbgA:
undetectable
3nlyB-4mbgA:
undetectable
3nlyA-4mbgA:
21.16
3nlyB-4mbgA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 10 ALA B 211
ASP B 507
VAL B 260
VAL B 499
ILE B 500
None
1.02A 3oxvB-4mbgB:
undetectable
3oxvB-4mbgB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 8 PHE B 498
HIS B 495
GLU B 506
ILE B 508
None
1.33A 4cx7A-4mbgB:
undetectable
4cx7B-4mbgB:
undetectable
4cx7A-4mbgB:
21.54
4cx7B-4mbgB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 7 ILE B  72
PRO B  73
GLY B 479
GLU B 404
None
0.85A 4g0uB-4mbgB:
undetectable
4g0uB-4mbgB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
4 / 6 ALA A 257
GLN A 256
LEU A 219
LEU A 206
None
1.22A 4xp3A-4mbgA:
undetectable
4xp3A-4mbgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 6 LYS B  68
GLY B  71
TYR B 119
ARG B 408
None
1.29A 4yshB-4mbgB:
undetectable
4yshB-4mbgB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 9 SER B 202
ALA B 206
GLY B 192
GLY B 193
ALA B 183
None
1.08A 5d0xY-4mbgB:
undetectable
5d0xZ-4mbgB:
undetectable
5d0xY-4mbgB:
16.70
5d0xZ-4mbgB:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 8 HIS B 129
GLN B 415
LEU B 165
LEU B 438
None
1.14A 5hs6A-4mbgB:
undetectable
5hs6A-4mbgB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 10 GLY B 239
GLY B 287
LEU B 288
LEU B 322
TYR B 335
None
1.16A 5hwkA-4mbgB:
undetectable
5hwkA-4mbgB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 10 GLY B 239
GLY B 287
LEU B 288
LEU B 322
TYR B 335
None
1.16A 5hwkB-4mbgB:
undetectable
5hwkB-4mbgB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 6 LEU B 322
SER B 463
ARG B 327
GLY B 326
None
1.12A 5o4yF-4mbgB:
undetectable
5o4yF-4mbgB:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
4 / 7 ARG A 115
TYR A 152
GLU A 132
TRP A 155
None
1.16A 5umwB-4mbgA:
undetectable
5umwE-4mbgA:
undetectable
5umwB-4mbgA:
14.53
5umwE-4mbgA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
5 / 12 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
1.06A 5v0vA-4mbgB:
undetectable
5v0vA-4mbgB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
4 / 5 ALA B 201
SER B 202
GLY B 191
TYR A  74
K  B 605 (-3.4A)
None
None
None
1.20A 5yodD-4mbgB:
undetectable
5yodD-4mbgB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
4 / 5 SER B 303
TYR B 314
GLY B 304
TYR A 147
None
FPP  B 601 (-4.4A)
None
FPP  B 601 (-4.0A)
1.44A 5yodH-4mbgB:
undetectable
5yodH-4mbgB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 TYR A  39
ILE A  66
ARG A  47
LEU A  46
GLY B 193
None
None
EDO  A 401 ( 2.9A)
EDO  A 402 (-4.5A)
None
1.13A 5zwrA-4mbgA:
undetectable
5zwrA-4mbgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
5 / 12 TYR A  39
ILE A  66
TYR A  35
ARG A  47
GLY B 193
None
None
EDO  A 401 (-3.8A)
EDO  A 401 ( 2.9A)
None
0.93A 5zwrA-4mbgA:
undetectable
5zwrA-4mbgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
6 / 12 VAL B 251
LEU B 319
ALA B 318
LEU B 341
THR B 340
GLY A 205
None
1.34A 6b0cD-4mbgB:
undetectable
6b0cD-4mbgB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus)
4 / 7 ASN A 182
ASN A 187
GLU B 309
ARG B 359
None
None
None
FPP  B 601 (-3.9A)
1.24A 6b8kA-4mbgA:
undetectable
6b8kA-4mbgA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
4 / 6 GLN A 235
VAL A 227
ARG A 245
PRO A 247
None
1.27A 6brdB-4mbgA:
undetectable
6brdB-4mbgA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus)
4 / 7 TYR B 436
HIS B 370
LEU B 164
TYR B 156
None
1.13A 6g2pA-4mbgB:
undetectable
6g2pA-4mbgB:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus)
4 / 8 ASN A  99
ASP A 171
ARG A 153
ARG A 167
None
1.24A 6hisA-4mbgA:
2.4
6hisE-4mbgA:
2.3
6hisA-4mbgA:
10.68
6hisE-4mbgA:
10.68