SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 8 SER A 420
LEU A 422
ILE A 425
THR A 416
 None
 0.96A 1sbrA-4mboA:
undetectable		 1sbrA-4mboA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		3 / 3 LEU A 542
PHE A 562
ARG A 485
 None
 0.79A 1xdkF-4mboA:
undetectable		 1xdkF-4mboA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 11 PRO A 531
ILE A 486
HIS A 625
GLU A 496
ASN A 627
 None
None
MLZ  A 601 ( 4.1A)
MLZ  A 601 ( 4.4A)
MLZ  A 601 ( 4.0A)
 1.44A 2aqjA-4mboA:
undetectable		 2aqjA-4mboA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 7 SER A 484
TYR A 498
THR A 500
VAL A 482
 None
 1.17A 2uz2A-4mboA:
undetectable		 2uz2A-4mboA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 11 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.00A 3clbA-4mboA:
undetectable		 3clbA-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 12 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.00A 3clbC-4mboA:
undetectable		 3clbC-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		3 / 3 ASN A 423
ASP A 393
GLN A 397
 None
 0.52A 3eeyC-4mboA:
undetectable		 3eeyC-4mboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		3 / 3 ASN A 423
ASP A 393
GLN A 397
 None
 0.53A 3eeyD-4mboA:
undetectable		 3eeyD-4mboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		3 / 3 ASN A 423
ASP A 393
GLN A 397
 None
 0.50A 3eeyE-4mboA:
undetectable		 3eeyE-4mboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 12 VAL A 597
TYR A 498
SER A 608
SER A 570
ILE A 502
 None
 1.37A 3frqA-4mboA:
undetectable		 3frqA-4mboA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 10 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.02A 3hbbA-4mboA:
undetectable		 3hbbA-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 11 ASP A 574
ILE A 599
PRO A 600
LEU A 606
ILE A 522
 None
None
MLZ  A 601 ( 3.7A)
None
None
 1.03A 3hbbC-4mboA:
undetectable		 3hbbC-4mboA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 8 TYR A 569
VAL A 565
VAL A 594
GLN A 501
 None
 0.85A 3hjoA-4mboA:
undetectable		 3hjoA-4mboA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 5 ARG A 464
GLU A 463
PHE A 450
PRO A 435
 None
 1.46A 3r4xA-4mboA:
undetectable		 3r4xA-4mboA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		3 / 3 TYR A 519
LEU A 542
LYS A 543
 None
 0.60A 3sueD-4mboA:
undetectable		 3sueD-4mboA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 5 ASN A 481
PRO A 504
GLY A 506
ASP A 564
 None
 1.10A 4n48B-4mboA:
undetectable		 4n48B-4mboA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 6 ILE A 382
HIS A 409
ILE A 440
VAL A 465
 None
 0.87A 4zj8A-4mboA:
undetectable		 4zj8A-4mboA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		5 / 12 GLN A 615
GLY A 618
SER A 611
THR A 609
TYR A 617
 None
MES  A 706 (-4.1A)
MES  A 706 ( 4.7A)
None
None
 1.31A 5hfjB-4mboA:
undetectable		 5hfjB-4mboA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 8 SER A 592
ASN A 503
VAL A 472
SER A 619
 None
 1.02A 5m8rB-4mboA:
undetectable		 5m8rB-4mboA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)
(Streptococcus
agalactiae) 		4 / 8 SER A 592
ASN A 503
VAL A 472
SER A 619
 None
 1.00A 5m8rD-4mboA:
undetectable		 5m8rD-4mboA:
21.41