SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		4 / 7 SER A 262
HIS A 529
SER A 395
ARG A 396
 None
 0.99A 1ibgL-4mbrA:
5.8		 1ibgL-4mbrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		5 / 9 VAL A 301
VAL A 325
TYR A 317
GLY A 315
LEU A 346
 None
 1.34A 1lwfA-4mbrA:
undetectable		 1lwfA-4mbrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		5 / 12 LEU A 346
VAL A 364
LEU A 242
ILE A 284
ILE A 344
 None
 1.02A 4ltwA-4mbrA:
undetectable		 4ltwA-4mbrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		4 / 7 VAL A 393
LEU A 516
SER A 517
GLU A 521
 None
 0.88A 4zphA-4mbrA:
undetectable
4zphB-4mbrA:
undetectable		 4zphA-4mbrA:
19.33
4zphB-4mbrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		3 / 3 SER A 319
TYR A 298
TYR A 317
 None
 0.77A 5lakA-4mbrA:
undetectable
5lakI-4mbrA:
undetectable		 5lakA-4mbrA:
22.91
5lakI-4mbrA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		3 / 3 SER A 319
TYR A 298
TYR A 317
 None
 0.83A 5lakC-4mbrA:
undetectable
5lakJ-4mbrA:
undetectable		 5lakC-4mbrA:
22.91
5lakJ-4mbrA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		3 / 3 MET A 460
ASP A 260
ARG A 384
 None
 1.20A 5z6jA-4mbrA:
undetectable		 5z6jA-4mbrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		5 / 12 GLY A 425
LYS A 418
SER A 419
ASP A 416
ARG A 384
 None
 1.31A 5zvgA-4mbrA:
undetectable		 5zvgA-4mbrA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		5 / 12 GLY A 425
LYS A 418
SER A 419
ASP A 416
ARG A 384
 None
 1.32A 5zvgB-4mbrA:
undetectable		 5zvgB-4mbrA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4mbr SERINE-RICH REPEAT
PROTEIN 2
(Streptococcus
agalactiae) 		3 / 3 TRP A 347
ILE A 290
ASP A 291
 None
 0.86A 6i0y7-4mbrA:
undetectable		 6i0y7-4mbrA:
6.37