SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		3 / 3 GLN A 130
HIS A 271
PRO A 144
 SIA  A 406 (-4.3A)
SIA  A 406 (-4.2A)
None
 0.90A 1d8cA-4mbzA:
undetectable		 1d8cA-4mbzA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		3 / 3 ALA A 268
VAL A 270
TRP A 280
 None
 0.87A 1nt6A-4mbzA:
undetectable		 1nt6A-4mbzA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		3 / 3 ALA A 268
VAL A 270
TRP A 280
 None
 0.88A 1nt6B-4mbzA:
undetectable		 1nt6B-4mbzA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		5 / 12 CYH A  87
PRO A 205
PRO A  51
TYR A 150
ILE A 267
 None
 1.19A 1z9hA-4mbzA:
undetectable		 1z9hA-4mbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		5 / 12 CYH A  87
PRO A 205
PRO A  51
TYR A 150
ILE A 267
 None
 1.19A 1z9hB-4mbzA:
undetectable		 1z9hB-4mbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		5 / 12 CYH A  87
PRO A 205
PRO A  51
TYR A 150
ILE A 267
 None
 1.19A 1z9hC-4mbzA:
undetectable		 1z9hC-4mbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		5 / 12 CYH A  87
PRO A 205
PRO A  51
TYR A 150
ILE A 267
 None
 1.18A 1z9hD-4mbzA:
undetectable		 1z9hD-4mbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		4 / 7 PRO A 174
VAL A 177
GLU A 207
PRO A  80
 None
 1.03A 2v2gA-4mbzA:
undetectable
2v2gB-4mbzA:
undetectable		 2v2gA-4mbzA:
23.10
2v2gB-4mbzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		4 / 7 PRO A  80
PRO A 174
VAL A 177
GLU A 207
 None
 1.06A 2v2gC-4mbzA:
undetectable
2v2gD-4mbzA:
undetectable		 2v2gC-4mbzA:
23.10
2v2gD-4mbzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		5 / 9 ALA A 167
GLY A 164
ILE A 180
PRO A 205
LEU A  85
 None
None
CL  A 402 ( 4.4A)
None
None
 1.22A 3u7sB-4mbzA:
undetectable		 3u7sB-4mbzA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		5 / 12 TYR A 222
GLY A 156
ASN A 216
PHE A 153
LEU A 262
 None
None
None
IPA  A 405 (-4.6A)
None
 1.19A 3vywA-4mbzA:
undetectable		 3vywA-4mbzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		5 / 12 TYR A 222
GLY A 156
ASN A 216
PHE A 153
LEU A 262
 None
None
None
IPA  A 405 (-4.6A)
None
 1.20A 3vywB-4mbzA:
undetectable		 3vywB-4mbzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4mbz MAJOR CAPSID PROTEIN
VP1
(African
green
monkey
polyomavirus) 		4 / 6 PRO A 253
LEU A 262
PHE A 153
LEU A 160
 EDO  A 403 (-4.2A)
None
IPA  A 405 (-4.6A)
None
 1.01A 5tl8A-4mbzA:
undetectable		 5tl8A-4mbzA:
19.71