SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 GLU A 334
THR A 261
VAL A 262
ALA A 255
 None
 1.09A 1fo4B-4mcaA:
undetectable		 1fo4B-4mcaA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 4 SER A 174
PHE A 245
GLU A 178
GLY A 249
 NA  A1004 (-3.1A)
GOL  A1002 (-3.6A)
None
None
 1.41A 1icvA-4mcaA:
undetectable
1icvB-4mcaA:
undetectable		 1icvA-4mcaA:
21.01
1icvB-4mcaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 9 GLU A  72
ARG A  75
LEU A  76
PHE A  64
GLY A  92
 None
 1.41A 1mjlA-4mcaA:
undetectable
1mjlB-4mcaA:
undetectable		 1mjlA-4mcaA:
14.01
1mjlB-4mcaA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 8 SER A  51
THR A  47
ASP A 153
GLU A 231
 None
 1.22A 1mxgA-4mcaA:
undetectable		 1mxgA-4mcaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
None
None
 1.33A 1v8bA-4mcaA:
2.5		 1v8bA-4mcaA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
None
None
 1.29A 1v8bB-4mcaA:
3.0		 1v8bB-4mcaA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		6 / 12 PHE A 260
GLY A 278
VAL A 296
LEU A 283
LEU A 309
LEU A 297
 None
 1.33A 1ya4C-4mcaA:
undetectable		 1ya4C-4mcaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 LEU A 305
CYH A 206
ASP A 171
ALA A 172
ALA A 236
 None
None
ZN  A1000 (-2.1A)
None
None
 1.10A 2br4A-4mcaA:
2.8		 2br4A-4mcaA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 5 HIS A 257
HIS A 254
VAL A 275
HIS A 271
 None
ZN  A1000 (-3.1A)
None
ZN  A1000 ( 3.3A)
 1.02A 2wkoF-4mcaA:
undetectable		 2wkoF-4mcaA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 5 LEU A 173
GLN A 282
THR A 279
THR A 295
 None
 1.35A 2zj0C-4mcaA:
2.4		 2zj0C-4mcaA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 4 LEU A 173
GLN A 282
THR A 279
THR A 295
 None
 1.32A 2zj0D-4mcaA:
undetectable		 2zj0D-4mcaA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 5 LEU A 173
GLN A 282
THR A 279
THR A 295
 None
 1.28A 3ce6B-4mcaA:
2.2		 3ce6B-4mcaA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
None
None
 1.31A 3g1uD-4mcaA:
undetectable		 3g1uD-4mcaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
None
None
None
NA  A1004 (-3.4A)
 0.93A 3g2oA-4mcaA:
undetectable		 3g2oA-4mcaA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
None
None
None
NA  A1004 (-3.4A)
 0.94A 3g2oB-4mcaA:
undetectable		 3g2oB-4mcaA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 TYR A 131
PHE A 137
THR A 279
GLY A 259
 None
 0.93A 3gssA-4mcaA:
undetectable		 3gssA-4mcaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 TYR A 131
PHE A 137
THR A 279
GLY A 259
 None
 0.93A 3gssB-4mcaA:
undetectable		 3gssB-4mcaA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 10 VAL A 275
LEU A 210
SER A 174
GLY A 272
GLY A 168
 None
None
NA  A1004 (-3.1A)
None
None
 1.05A 3ls4H-4mcaA:
undetectable		 3ls4H-4mcaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 6 SER A 195
ILE A   5
ASP A 121
THR A 335
 None
None
GOL  A1002 ( 2.2A)
None
 1.10A 3q70A-4mcaA:
undetectable		 3q70A-4mcaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		3 / 3 PHE A 177
SER A 288
GLN A 292
 None
 0.94A 3smtA-4mcaA:
undetectable		 3smtA-4mcaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 8 TYR A 131
HIS A 271
LEU A 250
MET A 190
 None
ZN  A1000 ( 3.3A)
None
None
 1.39A 3uzzB-4mcaA:
undetectable		 3uzzB-4mcaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 10 LEU A 127
GLY A 249
GLU A 178
GLY A 244
SER A 241
 None
None
None
None
NA  A1004 (-3.4A)
 1.27A 4bwlC-4mcaA:
3.2		 4bwlC-4mcaA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
 1.21A 4bz6C-4mcaA:
2.6		 4bz6C-4mcaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 LEU A 211
TYR A 207
ARG A 204
THR A 295
 None
 0.96A 4eq4A-4mcaA:
undetectable		 4eq4A-4mcaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 8 LEU A 263
ILE A 352
VAL A 348
GLY A 259
 None
 0.83A 4eq4B-4mcaA:
undetectable		 4eq4B-4mcaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 LEU A 211
TYR A 207
ARG A 204
THR A 295
 None
 0.92A 4eqlA-4mcaA:
undetectable		 4eqlA-4mcaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 LEU A 211
TYR A 207
ARG A 204
THR A 295
 None
 0.95A 4eqlB-4mcaA:
undetectable		 4eqlB-4mcaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 LEU A 113
ALA A 122
THR A 120
SER A 119
 None
GOL  A1002 ( 4.2A)
None
None
 1.12A 4iklA-4mcaA:
undetectable
4iklB-4mcaA:
undetectable		 4iklA-4mcaA:
15.22
4iklB-4mcaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 7 LEU A 211
TYR A 207
ARG A 204
THR A 295
 None
 0.93A 4l39B-4mcaA:
undetectable		 4l39B-4mcaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
 1.21A 4lxzC-4mcaA:
undetectable		 4lxzC-4mcaA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 5 GLY A 249
SER A 248
ALA A 179
PHE A 245
 None
None
None
GOL  A1002 (-3.6A)
 0.95A 4m93B-4mcaA:
undetectable
4m93C-4mcaA:
undetectable		 4m93B-4mcaA:
21.95
4m93C-4mcaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 ASN A 338
ALA A 191
GLY A 192
GLY A 193
ILE A   5
 None
 0.92A 4obwB-4mcaA:
2.0		 4obwB-4mcaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
 1.30A 4qa2A-4mcaA:
3.0		 4qa2A-4mcaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
 1.28A 4qa2B-4mcaA:
3.1		 4qa2B-4mcaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 GLY A 168
ALA A 167
ILE A 234
ASP A 121
PRO A 123
 None
None
None
GOL  A1002 ( 2.2A)
None
 1.28A 4rtpA-4mcaA:
undetectable		 4rtpA-4mcaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 6 LYS A  26
GLY A  22
TYR A  24
ALA A  20
 None
 0.83A 4yshB-4mcaA:
undetectable		 4yshB-4mcaA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		4 / 5 HIS A 254
HIS A 271
VAL A 275
ALA A 253
 ZN  A1000 (-3.1A)
ZN  A1000 ( 3.3A)
None
None
 1.39A 5i3bB-4mcaA:
undetectable		 5i3bB-4mcaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 9 GLY A  90
ALA A  44
VAL A  91
MET A  41
ILE A  89
 None
 1.38A 5i3cA-4mcaA:
undetectable		 5i3cA-4mcaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 11 ILE A 117
LEU A 164
ALA A 167
VAL A  40
LEU A  97
 None
 1.18A 5ji0A-4mcaA:
undetectable		 5ji0A-4mcaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 MET A 339
ALA A 255
HIS A 254
ALA A 253
THR A 279
 None
None
ZN  A1000 (-3.1A)
None
None
 1.06A 5k9dA-4mcaA:
undetectable		 5k9dA-4mcaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 THR A 120
GLY A 272
GLY A 170
ILE A 117
LEU A 164
 None
 1.02A 5l0zA-4mcaA:
undetectable		 5l0zA-4mcaA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
None
None
 1.27A 5m66A-4mcaA:
2.4		 5m66A-4mcaA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
None
None
 1.31A 5m66C-4mcaA:
undetectable		 5m66C-4mcaA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A1000 (-3.1A)
ZN  A1000 (-2.1A)
None
None
None
 1.30A 5utuF-4mcaA:
undetectable		 5utuF-4mcaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4mca GLYCEROL
DEHYDROGENASE
(Serratia
plymuthica) 		5 / 12 PRO A 306
ILE A 307
GLY A 278
ALA A 276
ALA A 255
 None
 1.05A 5zw4A-4mcaA:
3.5		 5zw4A-4mcaA:
23.20